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Neurologic Gait Disorders (Gait, Hemiplegic)

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Gait abnormalities that are a manifestation of nervous system dysfunction. These conditions may be caused by a wide variety of disorders which affect motor control, sensory feedback, and muscle strength including: CENTRAL NERVOUS SYSTEM DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or MUSCULAR DISEASES.

Also Known As:

Gait, Hemiplegic; Gait, Scissors; Marche a Petit Pas; Spastic Gait; Unsteady Gait; Gait Disorders, Neurologic; Charcot Gait; Charcot's Gait; Duck Gait; Gait Disorder, Sensorimotor; Gait Dysfunction, Neurologic; Gait, Athetotic; Gait, Broadened; Gait, Drop Foot; Gait, Festinating; Gait, Frontal; Gait, Hysterical; Gait, Reeling; Gait, Rigid; Gait, Shuffling; Gait, Spastic; Gait, Stumbling; Gait, Unsteady; Gait, Widebased; Locomotion Disorders, Neurologic; Neurologic Ambulation Disorders; Neurologic Locomotion Disorders; Rapid Fatigue of Gait; Sensorimotor Gait Disorder; Ambulation Disorder, Neurologic; Athetotic Gait; Broadened Gait; Charcot Gaits; Charcots Gait; Drop Foot Gait; Festinating Gait; Foot Gait, Drop; Frontal Gait; Gait Disorder, Neurologic; Gait Disorders, Sensorimotor; Gait Dysfunctions, Neurologic; Gait, Charcot; Gait, Charcot's; Gait, Duck; Gaits, Charcot; Hemiplegic Gait; Hysterical Gait; Locomotion Disorder, Neurologic; Neurologic Ambulation Disorder; Neurologic Gait Disorder; Neurologic Gait Dysfunction; Neurologic Gait Dysfunctions; Neurologic Locomotion Disorder; Reeling Gait; Rigid Gait; Scissors Gait; Sensorimotor Gait Disorders; Shuffling Gait; Shuffling Gaits; Stumbling Gait; Widebased Gait; Ambulation Disorders, Neurologic

Networked: 123 relevant articles (9 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Lethargy
2.	Wounds and Injuries (Trauma)
3.	Dizziness (Lightheadedness)
4.	Cerebral Palsy (Spastic Diplegia)
5.	Congenital Abnormalities (Deformity)

Experts

1.	Annweiler, C: 3 articles (01/2015 - 12/2009)
2.	Beauchet, O: 3 articles (01/2015 - 12/2009)
3.	Kon, Keisuke: 2 articles (05/2015 - 11/2013)
4.	Hayakawa, Yasuyuki: 2 articles (05/2015 - 11/2013)
5.	Haruna, Hirokazu: 2 articles (05/2015 - 11/2013)
6.	Nolan, Karen J: 2 articles (03/2011 - 01/2010)
7.	Yarossi, Mathew: 2 articles (03/2011 - 01/2010)
8.	Metz, Gerlinde A: 2 articles (05/2009 - 08/2005)
9.	Kumar, Neeraj: 2 articles (10/2006 - 02/2006)
10.	Rodríguez-Sánchez, Felicidad: 1 article (11/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neurologic Gait Disorders:

1.	Prednisone (Sone)FDA LinkGeneric 04/01/1998 - "All patients improved their spastic gait after prednisone treatment. "
2.	Phenytoin (Dilantin)FDA LinkGeneric 12/01/2004 - "Although acute phenytoin intoxication causes no mortality and has a good outcome, the unsteady gait increases the risk of injuries caused by falls. "
3.	Lactulose (Duphalac)FDA LinkGeneric 01/01/2014 - "The ammonia lowering therapy by the oral administration of lactulose successfully improved the spastic gait accompanied with the emergence of N30 and P38 in the tibial SEP. "
4.	Amifostine (Ethyol)FDA LinkGeneric 09/01/1986 - "WR 2721 produced lethargy, unsteady gait, and dishevelment but these signs all resolved completely within 1-3 days in survivors. "
5.	AmmoniaIBA 01/01/2014 - "The ammonia lowering therapy by the oral administration of lactulose successfully improved the spastic gait accompanied with the emergence of N30 and P38 in the tibial SEP. "
6.	deferasirox FDA Link 01/01/2013 - "The oral chelator deferasirox was effective in treating the left-side choreoathetosis and unsteady gait. "
7.	levodopa drug combination carbidopa (Nakom)FDA LinkGeneric 07/01/1996 - "Ten days after initiation of treatment with carbidopa-levodopa, her postural instability and unsteady gait slightly improved. "
8.	Botulinum Toxins (Botulinum Toxin)IBA 07/10/2002 - "The effects of botulinum toxin treatment on associated reactions of the upper limb on hemiplegic gait--a pilot study." 06/01/1999 - "Botulinum toxin A in the management of spastic gait disorders in children and young adults with cerebral palsy: a randomized, double-blind study of "high-dose" versus "low-dose" treatment." 06/01/1999 - "The present study demonstrated dose-dependent functional improvement of dynamic deformities and spastic gait pattern in children and young adults with CP treated with local injections of botulinum toxin. " 07/01/2001 - "Recent progress includes use of botulinum toxin for spastic gait in cerebral palsy, neurosurgical treatment of Parkinson's disease, and newer rehabilitation approaches to gait and balance training." 06/01/1999 - "The present study was performed to assess dose-response relationships of local botulinum toxin A (BtxA) treatment in children and teenagers with spastic gait due to cerebral palsy (CP) in a randomized, double-blind study employing a "high-dose" (200 units Botox per leg) and a "low-dose" (100 units Botox per leg) treatment arm in 33 patients with CP. "
9.	Amantadine (Aman)FDA LinkGeneric 01/01/2001 - "Amantadine increases gait steadiness in frontal gait disorder due to subcortical vascular encephalopathy: a double-blind randomized placebo-controlled trial based on quantitative gait analysis." 01/01/2001 - "In this small pilot study, amantadine tends to improve gait steadiness as evaluated by cadence, length of heel-to-toe movements in single support phase, variability in double support phase and double support time, in patients with moderate frontal gait disorder due to SVE. " 01/01/1994 - "Amantadine was discontinued in four residents (5%) because of adverse effects (agitation, confusion, unsteady gait). "
10.	Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)IBA 07/01/2001 - "Two patients treated in a phase I trial of oral 5-FU, leucovorin and eniluracil, an inhibitor of dihydropyrimidine dehydrogenase (DPD), developed delayed onset symptoms of unsteady gait and reduced sensation in the legs. "

Therapies and Procedures

1.	Orthotic Devices (Orthosis) 03/01/2003 - "Hemiplegic gait was improved by both orthoses. " 09/01/2010 - "The aim of this study was to assess the functional effects and mechanical contribution of Ankle Foot Orthoses (AFO) prescribed to overcome drop-foot gait. " 11/01/2013 - "Change in the Mechanical Energy of the Body Center of Mass in Hemiplegic Gait after Continuous Use of a Plantar Flexion Resistive Ankle-foot Orthosis." 03/01/2011 - "This research established a systematic method for analysing weight transfer during walking to evaluate the effect of an ankle foot orthosis on loading during double support in hemiplegic gait. " 01/01/2011 - "An ankle-foot orthosis with an oil damper (AFO-OD) was developed to resist plantarflexion motion, thereby improving hemiplegic gait performance. "
2.	Canes (Cane) 07/01/1999 - "A cane thus improved the hemiplegic gait by assisting the affected limb to smoothly shift the center of body mass toward the sound limb and to enhance push off during preswing phase. " 01/01/2015 - "A cane has been used to improve hemiplegic gait by assisting affected limb to smoothly shift body mass toward the sound limb. " 01/01/2014 - "The patient developed a spastic gait disturbance that forced her to use a cane. " 02/01/2005 - "An analysis of residents whose falls the MDS missed indicated that these residents had significantly more activity of daily living impairment and significantly less unsteady gait and cane/walker use. " 07/01/1999 - "The affected-side kinematics of hemiplegic gait with a cane showed increased pelvic obliquity, hip abduction, and ankle eversion during terminal stance phase; increased hip extension, knee extension, and ankle plantar-flexion during preswing phase; and increased hip adduction, knee flexion, and ankle dorsiflexion during swing phase as compared with hemiplegic gait without a cane. "
3.	Walkers 02/01/2004 - "Although the use of walkers is very effective for maintaining locomotive ability, patients who have symptoms such as frozen gait (FG) and festinating gait may fall even with a walker equipped with a brake as they cannot use the brake well in an emergency and fail to follow the accelerating walker. "
4.	Oral Administration 01/01/2014 - "The ammonia lowering therapy by the oral administration of lactulose successfully improved the spastic gait accompanied with the emergence of N30 and P38 in the tibial SEP. "
5.	Injections 08/01/1990 - "A forty-year-old female presented with an unsteady gait 13 years after receiving an eight-month course of human pituitary-derived gonadotrophin injections as treatment for infertility. " 06/01/1999 - "The present study demonstrated dose-dependent functional improvement of dynamic deformities and spastic gait pattern in children and young adults with CP treated with local injections of botulinum toxin. "