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Carotid Artery Injuries

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Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)

Also Known As:

Carotid Arteriopathies, Traumatic; Carotid False Aneurysm; False Aneurysm, Carotid; Injuries, Carotid Artery; Artery Injuries, Carotid; Artery Injury, Carotid; Artery Trauma, Carotid; Carotid Arteriopathy, Traumatic; Carotid Artery Injury; Carotid Artery Trauma; Carotid False Aneurysms; Injury, Carotid Artery; Pseudoaneurysm, Carotid; Traumatic Carotid Arteriopathy; Carotid Pseudoaneurysm; Trauma, Carotid Artery

Networked: 205 relevant articles (7 outcomes, 19 trials/studies)

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Disease Context: Research Results

Related Diseases

1.	Hyperplasia
2.	Neointima
3.	Thrombosis (Thrombus)
4.	Wounds and Injuries (Trauma)
5.	Neoplasms (Cancer)

Experts

1.	Konstantinides, Stavros: 6 articles (05/2013 - 10/2002)
2.	Huang, Lan: 5 articles (01/2015 - 08/2007)
3.	Yun, Yeo-Pyo: 5 articles (12/2014 - 09/2004)
4.	Kwon, Jin-Sook: 5 articles (07/2014 - 03/2004)
5.	Schäfer, Katrin: 5 articles (05/2013 - 10/2002)
6.	Kibbe, Melina R: 4 articles (01/2015 - 01/2008)
7.	Yin, Yangguang: 4 articles (01/2015 - 08/2007)
8.	Kim, Dong-Woon: 4 articles (06/2010 - 03/2004)
9.	Fay, William P: 4 articles (10/2009 - 03/2002)
10.	Loskutoff, David J: 4 articles (11/2004 - 10/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Carotid Artery Injuries:

1.	proline-nitric oxideIBA 12/01/2008 - "Using the rat carotid artery injury model to assess the efficacy of NO in vivo, we found that the NO donor PROLI/NO inhibited neointimal hyperplasia to the greatest extent in type II DM rodents, followed by metabolic syndrome, then controls. " 01/01/2008 - "We investigated the efficacy of perivascular delivery of two distinctly different diazeniumdiolate NO donors, 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO) (short half-life) and diazeniumdiolated poly(acrylonitrile) (PAN/NO) (long half-life), in powder or gel form (30% poloxamer 407), at inhibiting neointimal hyperplasia using the rat carotid artery injury model. "
2.	Heparin (Liquaemin)FDA LinkGeneric 10/01/2010 - "Heparin surface stent-graft for the treatment of a carotid pseudoaneurysm." 03/01/2002 - "In a rabbit model of carotid artery injury, intravenous administration of 10C12 or heparin decreased thrombosis dose dependently. " 04/01/1994 - "Consistent with this hypothesis, a murine monoclonal antibody to rabbit platelet factor 4 nearly completely inhibited the heparin-neutralizing activity present in rabbit thrombi (n = 3) generated by carotid artery injury. " 11/01/2009 - "To determine if M118 is effective in preventing thrombosis in the setting of a vascular plaque, apolipoprotein E knockout mice fed a high fat diet were injected with M118, enoxaparin, unfractionated heparin, or saline control and examined for arterial thrombosis using a rose bengal laser induced carotid artery injury model. "
3.	Proliferating Cell Nuclear Antigen (PCNA)IBA 01/01/2013 - "Furthermore, using a mouse carotid artery injury model, we found that treatment with 150 mg/kg I3C resulted in a significant reduction of the neointima/media ratio and cells positive for proliferating cell nuclear antigen. " 06/01/1994 - "We have used antisense phosphorothioate oligonucleotides to define the role played by proliferating cell nuclear antigen (PCNA) in neointimal accumulation of smooth muscle cells in a rat carotid artery injury model. " 06/01/1994 - "Antisense proliferating cell nuclear antigen oligonucleotides inhibit intimal hyperplasia in a rat carotid artery injury model."
4.	Rose BengalIBA 11/11/2010 - "In 2 carotid artery injury models (FeCl(3) and Rose Bengal/laser), fXII-deficient mice are more resistant to thrombosis than fXI- or factor IX (fIX)-deficient mice, raising the possibility that fXII and fXI function in distinct pathways. " 11/01/2009 - "To determine if M118 is effective in preventing thrombosis in the setting of a vascular plaque, apolipoprotein E knockout mice fed a high fat diet were injected with M118, enoxaparin, unfractionated heparin, or saline control and examined for arterial thrombosis using a rose bengal laser induced carotid artery injury model. "
5.	Polytetrafluoroethylene (Teflon)FDA Link 03/01/2002 - "This report details the case of an acute petrous carotid pseudoaneurysm after a myringotomy procedure that was effectively treated with an expanded polytetrafluoroethylene-covered stent. " 05/01/2003 - "Intrasellar latrogenic carotid pseudoaneurysm: endovascular treatment with a polytetrafluoroethylene-covered stent."
6.	ApolipoproteinsIBA 11/01/2003 - "We used the ferric chloride model to induce carotid artery injury in apolipoprotein E knockout (apoE-/-) and wild-type (WT) mice. " 11/01/2009 - "To determine if M118 is effective in preventing thrombosis in the setting of a vascular plaque, apolipoprotein E knockout mice fed a high fat diet were injected with M118, enoxaparin, unfractionated heparin, or saline control and examined for arterial thrombosis using a rose bengal laser induced carotid artery injury model. "
7.	Poloxamer (Poloxamer 407)IBA 01/01/2008 - "We investigated the efficacy of perivascular delivery of two distinctly different diazeniumdiolate NO donors, 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO) (short half-life) and diazeniumdiolated poly(acrylonitrile) (PAN/NO) (long half-life), in powder or gel form (30% poloxamer 407), at inhibiting neointimal hyperplasia using the rat carotid artery injury model. "
8.	Enoxaparin (Lovenox)FDA LinkGeneric 11/01/2009 - "To determine if M118 is effective in preventing thrombosis in the setting of a vascular plaque, apolipoprotein E knockout mice fed a high fat diet were injected with M118, enoxaparin, unfractionated heparin, or saline control and examined for arterial thrombosis using a rose bengal laser induced carotid artery injury model. "
9.	diazeniumdiolated poly(acrylonitrile)IBA 01/01/2008 - "We investigated the efficacy of perivascular delivery of two distinctly different diazeniumdiolate NO donors, 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO) (short half-life) and diazeniumdiolated poly(acrylonitrile) (PAN/NO) (long half-life), in powder or gel form (30% poloxamer 407), at inhibiting neointimal hyperplasia using the rat carotid artery injury model. "
10.	diazeniumdiolateIBA 01/01/2008 - "We investigated the efficacy of perivascular delivery of two distinctly different diazeniumdiolate NO donors, 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO) (short half-life) and diazeniumdiolated poly(acrylonitrile) (PAN/NO) (long half-life), in powder or gel form (30% poloxamer 407), at inhibiting neointimal hyperplasia using the rat carotid artery injury model. "

Therapies and Procedures

1.	Stents 03/01/2015 - "We report two cases of penetrating carotid artery injuries in children successfully managed with endovascularly placed covered stents. " 02/01/2015 - "However, mechanical complications including both stent fracture and carotid pseudoaneurysm are under-reported. " 02/01/2015 - "We report a case of carotid false aneurysm after stent placement for post-surgery restenosis. " 02/01/2015 - "Carotid false aneurysm after carotid stent fracture: report of a surgical solution." 05/01/2013 - "Rare treatment of radiation induced carotid pseudoaneurysm and ensuing carotid blowout syndrome with placement of multiple contiguous endovascular stents: a case report."
2.	Hemostatic Techniques 03/01/2011 - "The aim of this study is to compare the efficacy of endoscopically applied hemostatic techniques that maintain vascular flow in an animal model of carotid artery injury. " 03/01/2011 - "The efficacy of hemostatic techniques in the sheep model of carotid artery injury." 08/01/2014 - "Early and late complications of endoscopic hemostatic techniques following different carotid artery injury characteristics."
3.	Transplants (Transplant) 06/01/2013 - "Labelled omental grafts were transplanted into a murine carotid artery injury model. " 06/01/2012 - "Placement of an endovascular stent graft may be a safe and effective option for treatment of infected and non-infected carotid pseudoaneurysm." 12/01/2009 - "Endovascular Stent graft placement for posttranssphenoidal carotid artery injury is a useful technical adjunct to the management strategy and has the potential to minimize the risk of having to sacrifice the ICA. " 09/01/2009 - "To review a single-centre experience with stent-graft treatment of penetrating carotid artery injuries and long-term follow-up. " 09/01/2007 - "Endovascular repair of a carotid pseudoaneurysm with Fluency Plus stent graft implantation."
4.	Lasers (Laser) 05/01/2012 - "Laser-induced carotid artery injury model in the rat for therapeutic agent screening." 12/01/2005 - "In contrast to these responses to a laser injury in a microvascular bed, FVL did not provide sustained hemostasis following damage of large vessels in a ferric chloride carotid artery injury model, despite of the improvement of clotting times and high circulating thrombin levels. " 11/11/2010 - "In 2 carotid artery injury models (FeCl(3) and Rose Bengal/laser), fXII-deficient mice are more resistant to thrombosis than fXI- or factor IX (fIX)-deficient mice, raising the possibility that fXII and fXI function in distinct pathways. " 11/01/2009 - "To determine if M118 is effective in preventing thrombosis in the setting of a vascular plaque, apolipoprotein E knockout mice fed a high fat diet were injected with M118, enoxaparin, unfractionated heparin, or saline control and examined for arterial thrombosis using a rose bengal laser induced carotid artery injury model. "
5.	Oral Administration 09/01/2001 - "To investigate the effect of CT52923 on PDGFR signaling, in vivo studies demonstrated that CT52923 could significantly inhibit neointima formation following carotid artery injury by oral administration in the rat. " 01/01/2011 - "Oral administration of NSC-87877 (10 mg/kg) significantly suppressed neointima formation in a rat model of carotid artery injury. " 12/01/2014 - "In a rat carotid artery injury model, oral administration (20 mg/kg/day) of I3O for 3 days significantly prolonged occlusion time, and ADP- and collagen-induced platelet aggregation. "