Acute Subdural Hematoma

Accumulation of blood in the SUBDURAL SPACE with acute onset of neurological symptoms. Symptoms may include loss of consciousness, severe HEADACHE, and deteriorating mental status.

Also Known As:

Hematoma, Subdural, Acute; Acute Subdural Hematomas; Hematoma, Acute Subdural; Hematomas, Acute Subdural; Subdural Hematomas, Acute; Hemorrhage, Subdural, Acute; Subdural Hematoma, Acute

Networked: 320 relevant articles (12 outcomes, 30 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hematoma
2.	Chronic Subdural Hematoma
3.	Intracranial Hemorrhages (Intracranial Hemorrhage)
4.	Wounds and Injuries (Trauma)
5.	Brain Edema (Cerebral Edema)

Experts

1.	Radermacher, Peter: 3 articles (12/2021 - 01/2020)
2.	Nakagawa, Ichiro: 3 articles (01/2021 - 01/2013)
3.	Nakase, Hiroyuki: 3 articles (01/2021 - 01/2013)
4.	Bullock, M Ross: 3 articles (01/2019 - 04/2003)
5.	Dubinski, Daniel: 3 articles (01/2018 - 05/2017)
6.	Konczalla, Juergen: 3 articles (01/2018 - 05/2017)
7.	Seifert, Volker: 3 articles (01/2018 - 05/2017)
8.	Won, Sae-Yeon: 3 articles (01/2018 - 05/2017)
9.	Hutchinson, Peter J: 3 articles (05/2014 - 05/2012)
10.	Kolias, Angelos G: 3 articles (05/2014 - 05/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acute Subdural Hematoma:

1.	N-Methylaspartate (NMDA)IBA 07/01/1994 - "Effect of neuroprotective N-methyl-D-aspartate antagonists on increased intracranial pressure: studies in the rat acute subdural hematoma model." 06/01/1995 - "The effect of the glycine site-specific N-methyl-D-aspartate antagonist ACEA1021 on ischemic brain damage caused by acute subdural hematoma in the rat." 01/01/1992 - "Glucose hypermetabolism after acute subdural hematoma is ameliorated by a competitive NMDA antagonist." 06/01/1991 - "These data demonstrate the anti-ischemic efficacy of NMDA antagonists in an animal model of intracranial hemorrhage in which intracranial pressure is elevated, and suggest that excitotoxic mechanisms (which are susceptible to antagonism by D-CPP-ene) may play a role in the ischemic brain damage which is observed in patients who die after acute subdural hematoma." 06/01/1997 - "The neuroprotective effect of the forebrain-selective NMDA antagonist CP101,606 upon focal ischemic brain damage caused by acute subdural hematoma in the rat."
2.	Neuroprotective AgentsIBA 10/05/2001 - "In the rat, neuroprotective effects were obtained in the acute subdural hematoma model (efficacy of 40-50% at 0.01 and 0.03 mg/kg/h, i.v. infusion during the 4 h following surgery); whereas in the middle cerebral artery occlusion model, a trend for a neuroprotective effect was obtained after triple i.v. bolus application of 0.03-3 mg/kg, given immediately, 2 and 4 h after occlusion. " 10/23/1999 - "We tested the neuroprotective effect of a novel, high affinity serotonin (5-HT1A) agonist, BAY X3702, in a rat model of acute subdural hematoma (ASDH). " 10/23/1999 - "The neuroprotective effect of a new serotonin receptor agonist, BAY X3702, upon focal ischemic brain damage caused by acute subdural hematoma in the rat." 06/26/2013 - "Neuroprotective effect of suppression of astrocytic activation by arundic acid on brain injuries in rats with acute subdural hematomas." 06/01/1997 - "The neuroprotective effect of the forebrain-selective NMDA antagonist CP101,606 upon focal ischemic brain damage caused by acute subdural hematoma in the rat."
3.	SDZ EAA 494 (cppene)IBA 06/01/1991 - "These data demonstrate the anti-ischemic efficacy of NMDA antagonists in an animal model of intracranial hemorrhage in which intracranial pressure is elevated, and suggest that excitotoxic mechanisms (which are susceptible to antagonism by D-CPP-ene) may play a role in the ischemic brain damage which is observed in patients who die after acute subdural hematoma." 06/01/1991 - "The ability of a competitive N-methyl-D-aspartate (NMDA) receptor antagonist (D-CPP-ene) to reduce irreversible brain damage has been examined in a rodent model of acute subdural hematoma. " 01/01/1992 - "We have measured regional cerebral glucose metabolism (2-deoxyglucose autoradiography) in a new rat model of acute subdural hematoma and compared the changes to those seen in sham-operated control animals and animals pretreated with a high-affinity competitive NMDA antagonist, D-CPP-ene. " 07/01/1994 - "Because the majority of clinical conditions in which focal brain ischemia occurs are associated with high intracranial pressure (ICP), we have used the rat acute subdural hematoma model to evaluate the effects of three glutamate N-methyl-D-aspartate antagonists, MK-801, CGS 19755 (SELFOTEL), D-CPP-ene, and mannitol, upon ICP and also upon the volume of ischemic brain damage. "
4.	5-methoxy-methylindoleacetic acid (DBI)IBA 07/01/2007 - "The aim of this study was to analyze and compare the epidemiology of injury mechanisms in acute subdural hematoma (ASDH) with those of diffuse brain injury (DBI) in the Japan Neurotrauma Data Bank. " 10/01/1993 - "The IQ, especially performance IQ, of acute subdural hematoma (EDH) or severe diffuse brain injury (DBI) was lower than that caused by other types of lesion. " 05/01/2004 - "The aim of this study was to assess the effect of rapid or delayed surgical evacuation on the physiological consequence and brain edema formation in a rat model of acute subdural hematoma (SDH) coupled with either diffuse brain injury (DBI) or hypoxemia. " 01/01/2007 - "Traumatic acute subdural hematomas (ASDH) in Japan Neurotrauma Data Bank were categorized into focal brain injury (FBI) group and diffuse brain injury (DBI) group, and were analyzed to clarify the pathophysiological and therapeutic aspects of these injuries. "
5.	Free RadicalsIBA 04/01/2003 - "Recent studies have shown that there is increased production of deleterious free radicals following acute subdural hematoma (ASDH). " 02/01/1999 - "To study the possible negative effects of this strategy, we tested the effect of an allosteric modifier of hemoglobin (RSR13) on free radical production in the rat acute subdural hematoma (ASDH) model, both under normoxic as well as under hyperoxic, normobaric conditions. " 04/01/2003 - "Tempol, a novel stable nitroxide, reduces brain damage and free radical production, after acute subdural hematoma in the rat."
6.	AnticoagulantsIBA 10/01/2022 - "Although it is often assumed that preinjury anticoagulant (AC) or antiplatelet (AP) use is associated with poorer outcomes among those with acute subdural hematoma (aSDH), previous studies have had varied results. " 01/01/2016 - "Do Age and Anticoagulants Affect the Natural History of Acute Subdural Hematomas?" 07/01/1960 - "[2 cases of acute subdural hematomas in the course of anticoagulant treatments]." 11/01/2017 - "OBJECTIVE Isolated acute subdural hematoma (aSDH) is increasing in older populations and so is the use of oral anticoagulant therapy (OAT). " 11/01/2017 - "Acute subdural hematoma in patients on oral anticoagulant therapy: management and outcome."
7.	Glucose (Dextrose)FDA LinkGeneric 03/01/1992 - "A study is described in which local glucose utilization is measured 2 or 4 hours after induction of acute subdural hematoma in the rat. " 03/01/1992 - "Transient glucose hypermetabolism after acute subdural hematoma in the rat." 03/01/2010 - "Blood constituents trigger brain swelling, tissue death, and reduction of glucose metabolism early after acute subdural hematoma in rats." 01/01/1992 - "Glucose hypermetabolism after acute subdural hematoma is ameliorated by a competitive NMDA antagonist." 01/01/1992 - "We have measured regional cerebral glucose metabolism (2-deoxyglucose autoradiography) in a new rat model of acute subdural hematoma and compared the changes to those seen in sham-operated control animals and animals pretreated with a high-affinity competitive NMDA antagonist, D-CPP-ene. "
8.	Dizocilpine Maleate (Dizocilpine)IBA 06/01/2008 - "Effects of memantine and MK-801 on ischemia in an experimental model of acute subdural hematoma." 06/01/2008 - "This study has been designed to investigate the development of cerebral ischemia and ischemic edema under experimental acute subdural hematoma and the effect of memantine (Sigma M-9292) and MK-801 (Sigma M-107) in the treatment of ischemia. " 07/01/1994 - "Because the majority of clinical conditions in which focal brain ischemia occurs are associated with high intracranial pressure (ICP), we have used the rat acute subdural hematoma model to evaluate the effects of three glutamate N-methyl-D-aspartate antagonists, MK-801, CGS 19755 (SELFOTEL), D-CPP-ene, and mannitol, upon ICP and also upon the volume of ischemic brain damage. "
9.	Mannitol (Osmitrol)FDA LinkGeneric 10/01/2001 - "Improving clinical outcomes from acute subdural hematomas with the emergency preoperative administration of high doses of mannitol: a randomized trial." 10/01/2001 - "One hundred seventy-eight adult patients with non-missile, traumatic, acute, subdural hematomas were prospectively and randomly assigned to receive emergency, preoperative, intravenous HDM treatment (91 patients), compared with a control group treated with a lower preoperative mannitol dose (87 patients). " 10/01/2001 - "To evaluate clinical outcomes and postoperative physiological findings for comatose patients with acute subdural hematomas who received preoperative high-dose mannitol (HDM) versus conventional-dose mannitol treatment. " 07/01/1994 - "Because the majority of clinical conditions in which focal brain ischemia occurs are associated with high intracranial pressure (ICP), we have used the rat acute subdural hematoma model to evaluate the effects of three glutamate N-methyl-D-aspartate antagonists, MK-801, CGS 19755 (SELFOTEL), D-CPP-ene, and mannitol, upon ICP and also upon the volume of ischemic brain damage. "
10.	Indicators and Reagents (Reagents)IBA 10/01/2022 - "More refined guidelines and hopefully class I evidence will be established with the ongoing trials: randomized evaluation of surgery with craniectomy for patients undergoing evacuation of acute subdural hematoma (RESCUE-ASDH), prospective randomized evaluation of decompressive ipsilateral craniectomy for traumatic acute epidural hematoma (PREDICT-AEDH), and pragmatic explanatory continuum indicator summary (PRECIS)." 01/01/2015 - "Sequential analysis of the simulated trauma progression indicates that an increase in acute subdural hematoma injury risk indicator occurs at an early stage of the trauma, whereas an increase in diffuse axonal injury risk indicators occurs at a later stage. "

Therapies and Procedures

1.	Decompressive Craniectomy 01/01/2022 - "Primary decompressive craniectomy after STBI for post-traumatic acute subdural hematoma improved the favorable outcome whenever the initial GCS > 4 among adult patients." 02/01/2017 - "[Emergency Decompressive Craniotomy in the Emergency Room was Effective in Severe Acute Subdural Hematoma Treatment:Two Case Reports]." 01/01/2013 - "Decompressive craniectomy for acute subdural hematomas: time for a randomized trial." 02/01/2023 - "Surgery for acute subdural hematoma: the value of pre-emptive decompressive craniectomy by propensity score analysis." 01/01/2023 - "Infantile severe acute subdural hematomas (ASDHs) usually require a decompressive craniotomy. "
2.	Craniotomy 08/01/2022 - "In this study, we aimed to share our experience with the endoscopic-assisted evacuation of acute subdural hematoma, a less invasive procedure compared to standard craniotomy. " 04/05/2022 - "The role of the craniotomy size in the surgical evacuation of acute subdural hematomas in elderly patients: a retrospective multicentric study." 11/18/2023 - "Craniotomy versus craniectomy for traumatic acute subdural hematoma-coarsened exact matched analysis of outcomes." 11/01/2023 - "How I do it: simplified craniotomy for acute subdural hematoma in the elderly." 08/31/2023 - "Craniectomy or Craniotomy for Acute Subdural Hematoma. "
3.	Trephining 07/01/2015 - "The present study reports the cases of two elderly patients that benefitted from trepanation and drainage of an acute subdural hematoma. " 07/01/2015 - "Preoperative trepanation and drainage in an emergency ward may reduce intracranial pressure, shorten operation time and lower patient mortality, and is thus applicable to the treatment of acute subdural hematoma. " 07/01/2015 - "Preoperative trepanation and drainage for acute subdural hematoma: Two case reports." 04/01/2022 - "Rapid Spontaneous Resolution of Contralateral Lentiform Acute Subdural Hematoma After Burr Hole Trephination for Chronic Subdural Hematoma." 10/01/2019 - "The principle operation of acute subdural hematoma (ASDH) is a craniotomy with hematoma removal, but a trephination with hematoma evacuation may be another method in selected cases. "
4.	Conservative Treatment 03/01/2014 - "Spontaneous resolution of large acute subdural hematoma and the value of neurological exam in conservative management of high risk patients." 09/01/2019 - "Frequency of and Risk Factors for Chronification in Traumatic Acute Subdural Hematoma following Conservative Therapy." 09/01/2008 - "The conservative management of patients with acute subdural hematomas can be a viable alternative in certain cases. " 09/01/2008 - "Conservative management outcomes of traumatic acute subdural hematomas." 12/01/2007 - "Three factors were significant in this case: signs and symptoms occurred spontaneously; the presence of an acute subdural hematoma exclusively contralateral to the AC; successful outcome of the conservative treatment."
5.	Punctures 10/01/2022 - "Acute subdural hematoma after dural puncture." 05/01/2021 - "The ventricular puncture remains a delicate gesture which must be carried out by a qualified neurosurgeon because of the risks of complications such as an acute subdural hematoma." 05/01/2021 - "Acute subdural hematoma post ventricular puncture is rarely reported in the literature. " 05/01/2021 - "In this article we report the very first case of acute subdural hematoma after ventricular puncture of cerebrospinal fluid. " 05/01/2021 - "Acute subdural hematoma post ventricular puncture in infants: A case report and review of the literature."