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Acute Subdural Hematoma

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Accumulation of blood in the SUBDURAL SPACE with acute onset of neurological symptoms. Symptoms may include loss of consciousness, severe HEADACHE, and deteriorating mental status.

Also Known As:

Hematoma, Subdural, Acute; Acute Subdural Hematomas; Hematoma, Acute Subdural; Hematomas, Acute Subdural; Subdural Hematomas, Acute; Hemorrhage, Subdural, Acute; Subdural Hematoma, Acute

Networked: 133 relevant articles (3 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Brain Edema (Cerebral Edema)
2.	Intracranial Hemorrhages (Intracranial Hemorrhage)
3.	Brain Injuries (Brain Injury)
4.	Hematoma
5.	Wounds and Injuries (Trauma)

Experts

1.	Kolias, Angelos G: 3 articles (05/2014 - 05/2012)
2.	Hutchinson, Peter J: 3 articles (05/2014 - 05/2012)
3.	Sawauchi, Satoshi: 3 articles (07/2007 - 05/2004)
4.	Manley, Geoffrey T: 2 articles (05/2014 - 10/2011)
5.	Menon, David K: 2 articles (05/2014 - 01/2013)
6.	Kon, Hiroyuki: 2 articles (09/2013 - 05/2003)
7.	Nakase, Hiroyuki: 2 articles (06/2013 - 01/2013)
8.	Nakagawa, Ichiro: 2 articles (06/2013 - 01/2013)
9.	Wajima, Daisuke: 2 articles (06/2013 - 01/2013)
10.	Roguski, Marie: 2 articles (04/2013 - 01/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acute Subdural Hematoma:

1.	N-Methylaspartate (NMDA)IBA 07/01/1994 - "Effect of neuroprotective N-methyl-D-aspartate antagonists on increased intracranial pressure: studies in the rat acute subdural hematoma model." 06/01/1997 - "The neuroprotective effect of the forebrain-selective NMDA antagonist CP101,606 upon focal ischemic brain damage caused by acute subdural hematoma in the rat." 06/01/1995 - "The effect of the glycine site-specific N-methyl-D-aspartate antagonist ACEA1021 on ischemic brain damage caused by acute subdural hematoma in the rat." 01/01/1992 - "Glucose hypermetabolism after acute subdural hematoma is ameliorated by a competitive NMDA antagonist." 06/01/1991 - "The ability of a competitive N-methyl-D-aspartate (NMDA) receptor antagonist (D-CPP-ene) to reduce irreversible brain damage has been examined in a rodent model of acute subdural hematoma. "
2.	SDZ EAA 494 (cppene)IBA 06/01/1991 - "The ability of a competitive N-methyl-D-aspartate (NMDA) receptor antagonist (D-CPP-ene) to reduce irreversible brain damage has been examined in a rodent model of acute subdural hematoma. " 06/01/1991 - "These data demonstrate the anti-ischemic efficacy of NMDA antagonists in an animal model of intracranial hemorrhage in which intracranial pressure is elevated, and suggest that excitotoxic mechanisms (which are susceptible to antagonism by D-CPP-ene) may play a role in the ischemic brain damage which is observed in patients who die after acute subdural hematoma." 01/01/1992 - "We have measured regional cerebral glucose metabolism (2-deoxyglucose autoradiography) in a new rat model of acute subdural hematoma and compared the changes to those seen in sham-operated control animals and animals pretreated with a high-affinity competitive NMDA antagonist, D-CPP-ene. " 07/01/1994 - "Because the majority of clinical conditions in which focal brain ischemia occurs are associated with high intracranial pressure (ICP), we have used the rat acute subdural hematoma model to evaluate the effects of three glutamate N-methyl-D-aspartate antagonists, MK-801, CGS 19755 (SELFOTEL), D-CPP-ene, and mannitol, upon ICP and also upon the volume of ischemic brain damage. "
3.	5-methoxy-methylindoleacetic acid (DBI)IBA 07/01/2007 - "The aim of this study was to analyze and compare the epidemiology of injury mechanisms in acute subdural hematoma (ASDH) with those of diffuse brain injury (DBI) in the Japan Neurotrauma Data Bank. " 10/01/1993 - "The IQ, especially performance IQ, of acute subdural hematoma (EDH) or severe diffuse brain injury (DBI) was lower than that caused by other types of lesion. " 01/01/2007 - "Traumatic acute subdural hematomas (ASDH) in Japan Neurotrauma Data Bank were categorized into focal brain injury (FBI) group and diffuse brain injury (DBI) group, and were analyzed to clarify the pathophysiological and therapeutic aspects of these injuries. " 05/01/2004 - "The aim of this study was to assess the effect of rapid or delayed surgical evacuation on the physiological consequence and brain edema formation in a rat model of acute subdural hematoma (SDH) coupled with either diffuse brain injury (DBI) or hypoxemia. "
4.	Glucose (Dextrose)FDA LinkGeneric 03/01/1992 - "A study is described in which local glucose utilization is measured 2 or 4 hours after induction of acute subdural hematoma in the rat. " 03/01/1992 - "Transient glucose hypermetabolism after acute subdural hematoma in the rat." 03/01/2010 - "Blood constituents trigger brain swelling, tissue death, and reduction of glucose metabolism early after acute subdural hematoma in rats." 01/01/1992 - "Glucose hypermetabolism after acute subdural hematoma is ameliorated by a competitive NMDA antagonist." 01/01/1992 - "We have measured regional cerebral glucose metabolism (2-deoxyglucose autoradiography) in a new rat model of acute subdural hematoma and compared the changes to those seen in sham-operated control animals and animals pretreated with a high-affinity competitive NMDA antagonist, D-CPP-ene. "
5.	Dizocilpine Maleate (Dizocilpine)IBA 06/01/2008 - "Effects of memantine and MK-801 on ischemia in an experimental model of acute subdural hematoma." 06/01/2008 - "This study has been designed to investigate the development of cerebral ischemia and ischemic edema under experimental acute subdural hematoma and the effect of memantine (Sigma M-9292) and MK-801 (Sigma M-107) in the treatment of ischemia. " 07/01/1994 - "Because the majority of clinical conditions in which focal brain ischemia occurs are associated with high intracranial pressure (ICP), we have used the rat acute subdural hematoma model to evaluate the effects of three glutamate N-methyl-D-aspartate antagonists, MK-801, CGS 19755 (SELFOTEL), D-CPP-ene, and mannitol, upon ICP and also upon the volume of ischemic brain damage. "
6.	Mannitol (Osmitrol)FDA LinkGeneric 10/01/2001 - "Improving clinical outcomes from acute subdural hematomas with the emergency preoperative administration of high doses of mannitol: a randomized trial." 10/01/2001 - "One hundred seventy-eight adult patients with non-missile, traumatic, acute, subdural hematomas were prospectively and randomly assigned to receive emergency, preoperative, intravenous HDM treatment (91 patients), compared with a control group treated with a lower preoperative mannitol dose (87 patients). " 10/01/2001 - "To evaluate clinical outcomes and postoperative physiological findings for comatose patients with acute subdural hematomas who received preoperative high-dose mannitol (HDM) versus conventional-dose mannitol treatment. " 07/01/1994 - "Because the majority of clinical conditions in which focal brain ischemia occurs are associated with high intracranial pressure (ICP), we have used the rat acute subdural hematoma model to evaluate the effects of three glutamate N-methyl-D-aspartate antagonists, MK-801, CGS 19755 (SELFOTEL), D-CPP-ene, and mannitol, upon ICP and also upon the volume of ischemic brain damage. "
7.	Cholinergic ReceptorsIBA 01/01/1993 - "This study used in vitro autoradiographic radioligand binding to measure beta-adrenergic and muscarinic cholinergic receptors and adenylate cyclase and protein kinase C (PKC) binding sites two h after acute subdural hematoma in rats. "
8.	Protein Kinase CIBA 01/01/1993 - "This study used in vitro autoradiographic radioligand binding to measure beta-adrenergic and muscarinic cholinergic receptors and adenylate cyclase and protein kinase C (PKC) binding sites two h after acute subdural hematoma in rats. "
9.	Memantine (Namenda)FDA Link 06/01/2008 - "Memantine, also an EAA antagonist, has been used for a long time in the treatment of different neurodegenerative diseases; however, it was not used in treatment of acute subdural hematoma before. " 06/01/2008 - "Effects of memantine and MK-801 on ischemia in an experimental model of acute subdural hematoma." 06/01/2008 - "This study has been designed to investigate the development of cerebral ischemia and ischemic edema under experimental acute subdural hematoma and the effect of memantine (Sigma M-9292) and MK-801 (Sigma M-107) in the treatment of ischemia. "
10.	Hemoglobins (Hemoglobin)IBA 02/01/1999 - "To study the possible negative effects of this strategy, we tested the effect of an allosteric modifier of hemoglobin (RSR13) on free radical production in the rat acute subdural hematoma (ASDH) model, both under normoxic as well as under hyperoxic, normobaric conditions. " 02/01/1999 - "Reducing hemoglobin oxygen affinity does not increase hydroxyl radicals after acute subdural hematoma in the rat."

Therapies and Procedures

1.	Decompressive Craniectomy 01/01/2013 - "Decompressive craniectomy for acute subdural hematomas: time for a randomized trial." 05/01/2014 - "Decompressive craniectomy for acute subdural hematomas." 01/01/2013 - "Letter to the editor: decompressive craniectomy for acute subdural hematoma." 11/01/2012 - "Patients with large cranial defects can manifest a secondary neurological deterioration known as the "syndrome of the trephined." This is the case of a 66-year-old female with a left-sided acute subdural hematoma, treated with decompressive craniectomy. " 01/01/2010 - "In the 34 patients who underwent evacuation of acute subdural hematomas, primary decompressive craniectomy was not associated with favorable neurological outcomes. "
2.	Surgical Decompression 03/01/2014 - "Acute subdural hematoma (ASDH) usually requires emergency surgical decompression, but rare cases exhibit rapid spontaneous resolution. " 03/01/2000 - "One patient had an acute subdural hematoma requiring emergent surgical decompression; the other had both an epidural hematoma and pneumocephalus that did not require surgery. "
3.	Craniotomy 12/01/2013 - "Acute subdural hematoma evacuations frequently necessitate large craniotomies with extended operative times and high relative blood loss, which can lead to additional morbidity for the patient. " 09/01/2012 - "Craniotomy for acute subdural hematoma in the elderly: not as bad as you thought." 01/01/2012 - "He underwent a bilateral craniotomy with artificial dura mater to remove bilateral acute subdural hematomas. " 01/01/2012 - "Three months before presentation she had underwent craniotomy for an episode of acute subdural hematoma caused by a severe neurotrauma. " 12/01/2011 - "However, it is still unclear which surgical approach (DC or craniotomy) is the optimal treatment strategy for severely head-injured patients with acute subdural hematoma (SDH). "
4.	Decompression 01/01/2009 - "We report the case of a 48-year-old male who developed an acute subdural hematoma after transsphenoidal decompression of a pituitary adenoma followed by a lumbar drain to conservatively manage postoperative cerebrospinal fluid rhinorrhoea. " 10/01/1999 - "We report a 29-year-old male with traumatic internal carotid artery (ICA) dissection who presented with cerebral ischemia developed after removal of a left acute subdural hematoma and external decompression. " 12/01/1992 - "The membranous layer probably separated from the dura mater following decompression after drainage of the contralateral hematoma, and this separation then damaged the bridging vein and superior sagittal sinus, resulting in the acute subdural hematoma." 06/18/1981 - "To discover which factors contributed to recovery after surgical intracranial decompression, we reviewed the records of 82 consecutive comatose patients with traumatic acute subdural hematoma (ASDH) who were treated in a single center under a uniform protocol. " 01/01/2012 - "Under a diagnosis of acute subdural hematoma and cerebral contusion, several neurosurgical procedures were performed at another hospital, including hematoma removal by craniotomy, external decompression, duraplasty, and cranioplasty. "
5.	Renal Dialysis (Hemodialysis) 06/01/2014 - "Hemodialysis (HD) may increase the risk of acute subdural hematoma (SDH) with high fatality, but the extent of this disease in non-western populations is unclear. " 01/01/1987 - "Hemodialysis-associated acute subdural hematoma. " 09/26/1970 - "Acute subdural hematoma during maintenance hemodialysis." 04/01/1994 - "A 33-year-old male was transferred from hemodialysis to peritoneal dialysis because of acute subdural hematoma. " 07/01/2009 - "Major complications included acute renal failure requiring hemodialysis (n = 4), reexploration for bleeding (n = 2), and acute subdural hematoma (n = 1). "