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Nervous System Trauma

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Traumatic injuries to the brain, cranial nerves, spinal cord, autonomic nervous system, or neuromuscular system, including iatrogenic injuries induced by surgical procedures.

Also Known As:

Trauma, Nervous System; Injuries, Nervous System; Craniocervical Injury; Injuries, Craniocervical; Injury, Craniocervical; Injury, Nervous System; Nervous System Injury; Nervous System Traumas; Craniocervical Injuries; Nervous System Injuries

Networked: 78 relevant articles (6 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Spinal Cord Injuries (Spinal Cord Injury)
2.	False Aneurysm (Pseudoaneurysm)
3.	Stroke (Strokes)
4.	Neurodegenerative Diseases (Neurodegenerative Disease)
5.	Neuralgia (Stump Neuralgia)

Experts

1.	Schachner, Melitta: 2 articles (01/2014 - 01/2012)
2.	Baumgärtner, Wolfgang: 2 articles (01/2013 - 12/2007)
3.	Wewetzer, Konstantin: 2 articles (01/2013 - 12/2007)
4.	Moritomo, Hisao: 2 articles (08/2008 - 01/2008)
5.	Tanaka, Hiroyuki: 2 articles (08/2008 - 01/2008)
6.	Yachi, Koji: 2 articles (08/2008 - 01/2008)
7.	Murase, Tsuyoshi: 2 articles (08/2008 - 01/2008)
8.	Okada, Kiyoshi: 2 articles (08/2008 - 01/2008)
9.	Yoshikawa, Hideki: 2 articles (08/2008 - 01/2008)
10.	Temporin, Ko: 2 articles (08/2008 - 01/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Nervous System Trauma:

1.	Nerve Growth Factors (Neurotrophins)IBA 05/01/2015 - "The strong repair and pro-survival functions of neurotrophins at their primary receptors, TrkA, TrkB and TrkC, have made them attractive candidates for treatment of nervous system injury and disease. " 07/01/2012 - "While neurotrophic factors have been shown to stimulate axonal growth in numerous animal models of nervous system injury, a lack of suitable growth substrates, an insufficient activation of neuron-intrinsic regenerative programs, and extracellular inhibitors of regeneration limit the efficacy of neurotrophic factor delivery for anatomical and functional recovery after spinal cord injury. " 10/01/2002 - "Changing the levels of neurotrophins in the spinal cord micro-environment after nervous system injury has been proposed to recover normal function, such that behavioral response to peripheral stimuli does not lead to chronic pain. "
2.	tebufenozide (Mimic)IBA 02/01/2003 - "These syndromes vary with regard to prognosis and therapeutic options, and competing diagnoses with very different natural histories and therapies often mask or mimic the signs and symptoms of radiation-related nervous system injury. " 01/01/2014 - "As a next step in developing an improved PSA-based approach to treat nervous system injuries, we searched for small organic compounds that mimic PSA and identified as a PSA mimetic 5-nonyloxytryptamine oxalate, described as a selective 5-hydroxytryptamine receptor 1B (5-HT1B ) agonist. "
3.	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 10/10/2011 - "It has been previously shown that peroxisome proliferators-activated receptor gamma (PPAR-γ) is beneficial for nervous system injury. "
4.	Peroxisome ProliferatorsIBA 10/10/2011 - "It has been previously shown that peroxisome proliferators-activated receptor gamma (PPAR-γ) is beneficial for nervous system injury. "
5.	Serotonin (5 Hydroxytryptamine)IBA 01/01/2014 - "As a next step in developing an improved PSA-based approach to treat nervous system injuries, we searched for small organic compounds that mimic PSA and identified as a PSA mimetic 5-nonyloxytryptamine oxalate, described as a selective 5-hydroxytryptamine receptor 1B (5-HT1B ) agonist. "
6.	RNA (Ribonucleic Acid)IBA 06/01/2015 - "Our study thus links axon regeneration to cellular stress and RNA metabolism, revealing new potential therapeutic targets for treating nervous system trauma. "
7.	Chondroitin Sulfate ProteoglycansIBA 06/15/2002 - "In the present study, we investigated the binding characteristics of two commonly studied outgrowth regulatory molecules: chondroitin sulfate proteoglycans (CSPGs), which are typically inhibitory to neurite outgrowth during development and following nervous system injury, and laminin, which is typically outgrowth promoting for many neuronal types. "
8.	Laminin (Merosin)IBA 06/15/2002 - "In the present study, we investigated the binding characteristics of two commonly studied outgrowth regulatory molecules: chondroitin sulfate proteoglycans (CSPGs), which are typically inhibitory to neurite outgrowth during development and following nervous system injury, and laminin, which is typically outgrowth promoting for many neuronal types. "
9.	Proteins (Proteins, Gene)IBA 01/01/2014 - "Knowledge of pro- and anti-inflammatory signals after nervous system injury is extensive, most of them being proteins acting through well-known receptors and intracellular cascades. " 01/01/2002 - "Alterations in the S-palmitoylation state of proteins substantially affect their cellular function, raising the possibility of new therapeutic targets in cancer and nervous system injury and disease." 03/01/2002 - "In response to many stresses and pathologic states, including different models of nervous system injury, cells synthesize a variety of proteins, most notably the inducible 72 kDa heat shock protein 70 (Hsp70), which plays important roles in maintaining cellular integrity and viability. " 01/01/2013 - "Autoantibodies to nervous system-specific proteins are elevated in sera of flight crew members: biomarkers for nervous system injury."
10.	CytokinesIBA 11/01/2004 - "Numerous cytokines are induced after nervous system injuries. " 08/01/1997 - "In clinical terms, these findings add further support to the use of these cytokines in nervous system trauma and disease." 06/12/2012 - "Erythropoietin (EPO) is a neuroprotective cytokine in models of ischemic and nervous system injury, where it reduces neuronal apoptosis and inflammatory cytokines and increases neurogenesis and angiogenesis. "

Therapies and Procedures

1.	Cell Transplantation 10/01/2013 - "In this paper, we address recent research related to the neuronal differentiation of amniotic fluid-derived cells, the therapeutic efficacy of these cells in animal models of nervous system injury, and the possible mechanisms mediating the positive outcomes achieved by amniotic fluid cell transplantation." 10/01/2013 - "Beneficial effects of amniotic fluid cell transplantation have been reported in various models of nervous system injury. " 01/01/2013 - "Olfactory mucosa (OM)-derived olfactory ensheathing cells (OECs) are attractive candidates for autologous cell transplantation-based therapy of nervous system injury. " 12/10/2007 - "Olfactory ensheathing cells (OECs) are promising candidates for autologous cell transplantation therapies of nervous system injury and disease. " 07/01/2010 - "Human bone marrow-derived mesenchymal stem cells (hMSCs) are considered a desirable cell source for autologous cell transplantation therapy to treat nervous system injury due to their ability to differentiate into specific cell types and render the tissue microenvironment more favorable for tissue repair by secreting various growth factors. "
2.	Transplants (Transplant) 11/01/2006 - "Preliminary results suggest that placement of stent-grafts is a safe and effective method of treating ICA traumatic pseudoaneurysms resulting from penetrating craniocervical injuries or skull base fractures. " 11/01/2006 - "We identified 20 patients with traumatic extracranial ICA pseudoaneurysms due to penetrating craniocervical injuries or skull base fractures who had been treated with covered stent-graft implantation. " 11/01/2006 - "To review the literature concerning the management with placement of covered stent-grafts of traumatic pseudoaneurysms of the extracranial internal carotid artery (ICA) resulting from penetrating craniocervical injuries or skull base fractures. "
3.	Stents 11/01/2006 - "Preliminary results suggest that placement of stent-grafts is a safe and effective method of treating ICA traumatic pseudoaneurysms resulting from penetrating craniocervical injuries or skull base fractures. " 11/01/2006 - "We identified 20 patients with traumatic extracranial ICA pseudoaneurysms due to penetrating craniocervical injuries or skull base fractures who had been treated with covered stent-graft implantation. " 11/01/2006 - "To review the literature concerning the management with placement of covered stent-grafts of traumatic pseudoaneurysms of the extracranial internal carotid artery (ICA) resulting from penetrating craniocervical injuries or skull base fractures. "
4.	Amputation 11/06/2013 - "Brain-machine and brain-computer interface technologies hold great promise for use in the recovery of sensory and motor functions lost as a result of nervous-system injuries or limb amputations. "
5.	Transplantation (Transplant Recipients) 02/01/2007 - "A designer self-assembling peptide nanofiber scaffold has been systematically studied with 10 commonly used scaffolds in a several week study using neural stem cells (NSC), a potential therapeutic source for cellular transplantations in nervous system injuries. "