Nocturnal Myoclonus Syndrome

Excessive periodic leg movements during sleep that cause micro-arousals and interfere with the maintenance of sleep. This condition induces a state of relative sleep deprivation which manifests as excessive daytime hypersomnolence. The movements are characterized by repetitive contractions of the tibialis anterior muscle, extension of the toe, and intermittent flexion of the hip, knee and ankle. (Adams et al., Principles of Neurology, 6th ed, p387)
Also Known As:
Excessive Periodic Sleep-Related Leg Movements; Periodic Leg Movements, Excessive, Sleep-Related; Sleep-Related Periodic Leg Movements, Excessive; Excessive Periodic Sleep Related Leg Movements; Myoclonus Syndrome, Nocturnal; Myoclonus Syndrome, Sleep; Myoclonus Syndromes, Sleep; Nocturnal Myoclonus Syndromes; Sleep Myoclonus Syndromes; Sleep Related Periodic Leg Movements, Excessive; Syndrome, Nocturnal Myoclonus; Syndrome, Sleep Myoclonus; Syndromes, Sleep Myoclonus; Periodic Limb Movement Disorder; Periodic Movement Disorder, Sleep; Sleep Disorder, Periodic Movements; Sleep Myoclonus Syndrome
Networked: 33 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Restless Legs Syndrome (Restless Legs)
2. Sleep Initiation and Maintenance Disorders (Insomnia)
3. Obstructive Sleep Apnea
4. Somnambulism (Sleepwalking)
5. REM Sleep Behavior Disorder


1. Stanzione, Paolo: 1 article (12/2015)
2. Pierantozzi, Mariangela: 1 article (12/2015)
3. Mercuri, Nicola Biagio: 1 article (12/2015)
4. Placidi, Fabio: 1 article (12/2015)
5. Liguori, Claudio: 1 article (12/2015)
6. Stefani, Alessandro: 1 article (12/2015)
7. Marciani, Maria Grazia: 1 article (12/2015)
8. Abakay, Ozlem: 1 article (05/2015)
9. Palanci, Yilmaz: 1 article (05/2015)
10. Evliyaoglu, Osman: 1 article (05/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Nocturnal Myoclonus Syndrome:
1. saccharated ferric oxideFDA Link
2. Clonazepam (Rivotril)FDA LinkGeneric
3. Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
4. Dopamine Agents (Dopaminergic Agents)IBA
5. Bupropion (Wellbutrin)FDA LinkGeneric
6. Dopamine Receptors (Dopamine Receptor)IBA
7. Pergolide (Permax)FDA Link
8. IronIBA
9. Dopamine (Intropin)FDA LinkGeneric
10. BenzodiazepinesIBA

Therapies and Procedures

1. Cardiac Resynchronization Therapy
2. Off-Label Use
3. Deep Brain Stimulation
4. Continuous Positive Airway Pressure
5. Drug Therapy (Chemotherapy)