Jet Lag Syndrome

A chronobiologic disorder resulting from rapid travel across a number of time zones, characterized by insomnia or hypersomnolence, fatigue, behavioral symptoms, headaches, and gastrointestinal disturbances. (From Cooper, Sleep, 1994, pp593-8)

Also Known As:

Networked: 318 relevant articles (38 outcomes, 39 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Sleep Wake Disorders
2.	Sleep Initiation and Maintenance Disorders (Insomnia)
3.	Circadian Rhythm Sleep Disorders (Delayed Sleep Phase Syndrome)
4.	Sleepiness
5.	Fatigue

Experts

1.	Cardinali, Daniel P: 9 articles (05/2011 - 01/2002)
2.	Yamaguchi, Yoshiaki: 6 articles (07/2018 - 10/2013)
3.	Pandi-Perumal, Seithikurippu R: 5 articles (01/2011 - 01/2007)
4.	Reiter, Russel J: 4 articles (01/2021 - 11/2008)
5.	Fu, Zhengwei: 4 articles (08/2019 - 04/2009)
6.	Okamura, Hitoshi: 4 articles (07/2018 - 10/2013)
7.	Reilly, T: 4 articles (10/2004 - 10/2000)
8.	Waterhouse, J: 4 articles (10/2004 - 10/2000)
9.	Wu, Tao: 3 articles (05/2018 - 04/2009)
10.	Brusco, Luis I: 3 articles (05/2011 - 04/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Jet Lag Syndrome:

1.	MelatoninIBA 01/01/2007 - "Similarly, among shift workers or individuals experiencing jet lag, melatonin is beneficial for promoting adjustment to work schedules and improving sleep quality. " 01/01/1996 - "Suitably timed melatonin administration hastened adaptation to phase shift and significantly improved self-rated jet lag in large numbers of time zone travellers. " 01/01/2002 - ": Melatonin is remarkably effective in preventing or reducing jet-lag, and occasional short-term use appears to be safe. " 01/01/2001 - "Melatonin is remarkably effective in preventing or reducing jet-lag, and occasional short-term use appears to be safe. " 02/01/1998 - "Melatonin may be effective in reducing jet lag. "
2.	tasimelteonIBA 01/01/2020 - "Efficacy of Tasimelteon (HETLIOZ®) in the Treatment of Jet Lag Disorder Evaluated in an 8-h Phase Advance Model; a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial." 01/01/2022 - "Once-daily tasimelteon (VEC-162) for jet lag following transmeridian travel: A multicenter, randomized, double-blind, placebo-controlled trial." 01/01/2022 - "This multicenter, randomized, placebo-controlled clinical trial (JET) assessed the physiological mechanism of jet lag induced by a real-life transmeridian flight and evaluated the efficacy of tasimelteon-a circadian regulator acting as a dual melatonin receptor agonist, in the treatment of Jet Lag Disorder (JLD). " 07/01/2009 - "Tasimelteon was effective in reducing sleep onset latency (in phase II and III clinical trials) and in resetting the circadian melatonin rhythm (in phase II trials), which indicated its potential suitability as treatment for jet lag, shift work and circadian rhythm sleep disorders. " 11/01/2010 - "With the introduction of melatonergic agonists such as ramelteon and tasimelteon, which have both a stronger affinity for MT₁ and MT₂ melatonin receptors and a longer half-life, new therapeutic options now exist for treating the sleep disturbances associated with jet lag. "
3.	Hypnotics and Sedatives (Sedatives)IBA 11/01/2000 - "Compounds with combined chronobiotic/hypnotic properties may be useful in conditions of jet lag or night work." 09/01/1996 - "Thus, the jet lag syndrome may be associated with a prolonged elevation of peripheral TSH levels that may be limited by treatment with bright light exposure or hypnotic facilitation of sleep." 11/01/2007 - "Hypnotic medications may be indicated to promote or improve daytime sleep among night shift workers (Guideline) and to treat jet lag-induced insomnia (Option). " 01/01/2001 - "For acute and situational insomnia, treatment should address the precipitating factors when possible, but in certain circumstances (eg, stressful events, travel, or jet lag), a hypnotic medication is necessary to alleviate sleep difficulties. " 04/01/1990 - "Sleep disturbance associated with transmeridian flights (jet lag) is used to illustrate the place of hypnotics in the management of a transient form of insomnia."
4.	Modafinil (Provigil)FDA Link 07/01/2010 - "Armodafinil at 150 mg/d provided a significant benefit in sleep latency on the MSLT (days 1-2: mean, 11.7 minutes vs 4.8 minutes for placebo; P<.001) and participants' perception of their overall condition in relation to jet lag symptoms (Patient Global Impression of Severity, days 1-2: mean, 1.6 vs 1.9 for placebo; P<.05). " 07/01/2010 - "To assess the effect of armodafinil, the longer-lasting isomer of modafinil, on jet lag disorder. " 02/01/2011 - "In addition, while not approved for this indication, armodafinil has been found to improve excessive sleepiness associated with jet-lag disorder. " 07/01/2010 - "A phase 3, double-blind, randomized, placebo-controlled study of armodafinil for excessive sleepiness associated with jet lag disorder." 01/01/2010 - "A critical review of armodafinil and modafinil for the treatment of sleepiness associated with jet lag."
5.	Galactose (Galactopyranose)FDA LinkGeneric 04/01/2009 - "Effects of age and jet lag on D-galactose induced aging process." 05/28/2018 - "Protective effects of astaxanthin on a combination of D-galactose and jet lag-induced aging model in mice." 05/28/2018 - "In the present study, we investigated the preventative effects of astaxanthin on aging using an accelerated aging model: mice chronically treated with a combination of D-galactose and jet lag. " 05/28/2018 - "Moreover, astaxanthin reversed the dysregulation of aging-related gene expression caused by the combination of D-galactose and jet lag in the liver and kidney of mice. " 05/28/2018 - "In conclusion, astaxanthin prevents liver weight loss, ameliorates locomotive muscular function, exerts significant anti-aging effects by reducing oxidative stress and improving the expression of age-related genes in D-galactose and jet lag-induced aging model."
6.	astaxanthine (astaxanthin)IBA 05/28/2018 - "Protective effects of astaxanthin on a combination of D-galactose and jet lag-induced aging model in mice." 05/28/2018 - "In the present study, we investigated the preventative effects of astaxanthin on aging using an accelerated aging model: mice chronically treated with a combination of D-galactose and jet lag. " 05/28/2018 - "Moreover, astaxanthin reversed the dysregulation of aging-related gene expression caused by the combination of D-galactose and jet lag in the liver and kidney of mice. " 05/28/2018 - "In conclusion, astaxanthin prevents liver weight loss, ameliorates locomotive muscular function, exerts significant anti-aging effects by reducing oxidative stress and improving the expression of age-related genes in D-galactose and jet lag-induced aging model."
7.	Vasopressins (Vasopressin)IBA 01/01/2020 - "Of late, there have been reports indicating linkage of AVP with jet lag in a positive way, suggesting vasopressin signalling as a possible remedy for ill effects and their improvement. " 07/27/2018 - "Vasopressin Signal Inhibition in Aged Mice Decreases Mortality under Chronic Jet Lag." 01/01/2015 - "Pharmacological blockade of V1a and V1b in the SCN of wild-type mice accelerated their recovery from jet lag symptoms, suggesting vasopressin signaling as a potential pharmaceutical intervention for the management of circadian rhythm misalignment." 10/01/2014 - "[Vasopressin-mediated neuronal circuit in the suprachiasmatic nucleus and jet lag]." 10/04/2013 - "Pharmacological blockade of V1a and V1b in the SCN of wild-type mice resulted in accelerated recovery from jet lag, which highlights the potential of vasopressin signaling as a therapeutic target for management of circadian rhythm misalignment, such as jet lag and shift work. "
8.	BenzodiazepinesIBA 02/28/2007 - "Symptoms from shiftwork or jet-lag are due to an internal desynchronisation of biological rhythms, and there is ample evidence that benzodiazepines are not effective in preventing these symptoms. " 01/01/1989 - "Such findings raise the possibility that short-acting benzodiazepines may prove useful in reducing the symptoms associated with 'jet-lag' and rotating shift-work schedules as well as in the treatment of various physical and mental illnesses that have been associated with a disorder of biological timekeeping." 11/01/2000 - "To determine whether appropriately timed administration of a short-acting benzodiazepine hypnotic, which has proven effective in an animal model of jet lag, also facilitates adaptation of circadian rhythmicity and sleep-wake homeostasis in a human model of jet lag. " 01/01/2019 - "Over-the-counter melatonin is widely used to alleviate jet lag and as a safer alternative to benzodiazepines and other sleeping aids8,9, and is one of the most popular supplements in the United States10. " 11/01/2000 - "A benzodiazepine hypnotic facilitates adaptation of circadian rhythms and sleep-wake homeostasis to an eight hour delay shift simulating westward jet lag."
9.	LipidsIBA 11/24/2017 - "As a conclusion, L-Carnitine was partly effective in preventing the disruption of circadian clock and lipid metabolic disorders induced by the chronic jet-lag." 01/01/2022 - "These results indicate that modulating light intensity is a potential strategy to prevent the negative metabolic consequences associated with jet lag or shift work.NEW & NOTEWORTHY Glucose and lipid homeostasis is altered by the CD cycles in a light-intensity-dependent manner. " 01/01/2021 - "Analyses of jet-lag (JL) mice, JL mice with oral melatonin administration (JL+MT), and the control for mRNA and protein expression regarding lipid uptake and accumulation in ileum and eWAT were made. "
10.	Melatonin Receptors (Melatonin Receptor)IBA 01/01/2022 - "This multicenter, randomized, placebo-controlled clinical trial (JET) assessed the physiological mechanism of jet lag induced by a real-life transmeridian flight and evaluated the efficacy of tasimelteon-a circadian regulator acting as a dual melatonin receptor agonist, in the treatment of Jet Lag Disorder (JLD). " 11/01/2010 - "With the introduction of melatonergic agonists such as ramelteon and tasimelteon, which have both a stronger affinity for MT₁ and MT₂ melatonin receptors and a longer half-life, new therapeutic options now exist for treating the sleep disturbances associated with jet lag. "

Therapies and Procedures

1.	Phototherapy (Light Therapy) 01/01/2020 - "The human circadian pacemaker entrains to the 24-h day, but interindividual differences in properties of the pacemaker, such as intrinsic period, affect chronotype and mediate responses to challenges to the circadian system, such as shift work and jet lag, and the efficacy of therapeutic interventions such as light therapy. " 01/01/2017 - "Since R6/2 mice can shift their rest-activity rhythms in response to a jet-lag paradigm and also respond positively to bright light therapy (1000 lx), we investigated whether or not a prolonged day length exposure could reduce their daytime activity and improve their behavioural circadian rhythms. " 01/01/2009 - "A lot of techniques of light therapy and pharmacological treatment are being used in order to reduce the jet lag symptoms, however their effectiveness is still being questioned. " 08/01/1999 - "Benefits of light therapy are less clear and treatment is an option in jet lag, shift work, and non-24-hour sleep-wake syndrome in some blind patients." 01/01/2021 - "We simulated different behavioral situations leading to perturbed rhythmicity, performed a detailed computational analysis of the dynamic response of the system under varying light schedules, and determined that (1) significant interindividual diversity and flexibility characterize adaptation to varying light schedules; (2) an individual's tolerances to jet lag and alternating shift work are positively correlated, while the tolerances to jet lag and transient shift work are negatively correlated, which indicates trade-offs in an individual's ability to maintain physiological rhythmicity; (3) weak light sensitivity leads to the reduction of circadian flexibility, implying that light therapy can be a potential approach to address shift work and jet lag related disorders. "
2.	Therapeutics 11/24/2021 - "These data are an important informative platform for the development of new noninvasive and nonpharmacological technologies for AD therapy as well as for preventing Aβ accumulation in the brain of people with disorder of Aβ metabolism, sleep deficit, elderly age, and jet lag." 05/01/2018 - "Jet lag: Heuristics and therapeutics." 09/01/2011 - "Despite recent advances in understanding circadian clock function and the mechanisms of jet lag, limited therapy is available at present for the treatment of disorders associated with long-distance travel. " 04/01/2011 - "Jet lag: current and potential therapies." 01/01/1995 - "[Therapy of jet lag]."
3.	Mediterranean Diet 07/30/2019 - "The aim of this study was to examine whether higher social jet lag is linked to lower adherence to the Mediterranean diet and whether it is associated with BMI (Body Mass Index). " 06/26/2020 - "Adherence to the Mediterranean diet is linked to better sleep quality and less social jet lag, but association with chronotype or sexual opinion remains unclear. " 07/30/2019 - "Our results revealed that individuals with greater social jet lag showed lower adherence to the Mediterranean diet and had a higher BMI. " 07/30/2019 - "Anthropometric parameters, adherence to the Mediterranean diet, chronotype and social jet lag were studied. " 07/30/2019 - "Social Jet Lag Associates Negatively with the Adherence to the Mediterranean Diet and Body Mass Index among Young Adults."
4.	Bariatric Surgery 01/01/2021 - "This study evaluated the association between social jet lag (SJL), a measure of circadian misalignment, and anthropometric, metabolic and food intake outcomes 6 months after bariatric surgery. "
5.	Transjugular Intrahepatic Portasystemic Shunt 09/01/2012 - " Do you have any tips for managing jet lag?" 08/01/2021 - "Practical tips to manage travel fatigue and jet lag in athletes." 01/01/2019 - "Therefore, we present ten tips to help hurdle the challenges of illness/injury at major athletics championships: (1) Prepare for travel (medical checking, vaccine, time-zone, jet lag, culture, food habits…), (2) Respect athlete characteristics and discipline specificity (sex, endurance/explosive), (3) Educate athletes and their entourages regarding prevention, (4) Vigilance of painful symptoms and subclinical illness markers, (5) Avoid infection risk (washing hands, safe food and drink, avoid contact with sick people…), (6) Train appropriately and optimally (physical conditioning, technical training, load management, and psychological preparation), (7) Health status (history of previous injuries, well-being in the month before championships), (8) Lifestyle (good sleep, regular hydration and nutrition with safe water/food, regular fruits and vegetables, improve recovery strategies…), (9) Environmental considerations (heat, cold, air cleaning, changes or climatic conditions…), (10) Safety (equipment, rules, own-practice in athletics, and extra-sport activities). "