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Circadian Rhythm Sleep Disorders (Delayed Sleep Phase Syndrome)

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Dyssomnias associated with disruption of the normal 24 hour sleep wake cycle secondary to travel (e.g., JET LAG SYNDROME), shift work, or other causes.

Also Known As:

Delayed Sleep Phase Syndrome; Advanced Sleep Phase Syndrome; Shift-Work Sleep Disorder; Sleep Disorders, Circadian Rhythm; Disturbed Nyctohemeral Rhythm; Non-24 Hour Sleep-Wake Disorder; Nonorganic Sleep Wake Cycle Disorders; Sleep Disorder, Shift-Work; Sleep-Wake Disorder, Non-24 Hour; Sleep-Wake Schedule Disorders; Cycle Disorder, Sleep-Wake; Cycle Disorders, Sleep-Wake; Disturbed Nyctohemeral Rhythms; Non 24 Hour Sleep Wake Disorder; Nyctohemeral Rhythm, Disturbed; Nyctohemeral Rhythms, Disturbed; Shift Work Sleep Disorder; Shift-Work Sleep Disorders; Sleep Disorder, Shift Work; Sleep Disorders, Shift-Work; Sleep Wake Cycle Disorders; Sleep Wake Disorder, Non 24 Hour; Sleep Wake Schedule Disorders; Sleep-Wake Cycle Disorder; Sleep-Wake Schedule Disorder; Sleep-Wake Cycle Disorders

Networked: 170 relevant articles (19 outcomes, 17 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Narcolepsy
2.	Obstructive Sleep Apnea
3.	Sleep Disorders
4.	Chronobiology Disorders (Circadian Rhythm Disorder)
5.	Disorders of Excessive Somnolence (Hypersomnia)

Experts

1.	Cardinali, Daniel P: 9 articles (05/2011 - 04/2002)
2.	Zee, Phyllis C: 7 articles (05/2011 - 10/2005)
3.	Spence, D Warren: 5 articles (01/2011 - 01/2007)
4.	Pandi-Perumal, Seithikurippu R: 5 articles (01/2011 - 01/2007)
5.	Roth, Thomas: 4 articles (02/2009 - 08/2005)
6.	Jan, James E: 4 articles (01/2009 - 11/2004)
7.	Dagan, Yaron: 4 articles (08/2008 - 09/2002)
8.	Schwartz, Jonathan R L: 4 articles (10/2007 - 01/2005)
9.	Mishima, Kazuo: 3 articles (07/2012 - 10/2004)
10.	Brusco, Luis I: 3 articles (05/2011 - 04/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Circadian Rhythm Sleep Disorders:

1.	MelatoninIBA 11/01/1996 - "Melatonin, which benefitted slightly over 80% of our patients, appears to be a safe, inexpensive, and a very effective treatment of sleep-wake cycle disorders. " 12/01/2005 - "There is some evidence to suggest that melatonin is effective in treating delayed sleep phase syndrome with short-term use. " 11/01/1994 - "Melatonin treatment has been reported to be effective in treatment of disorders such as jet lag and delayed sleep phase syndrome." 01/01/2008 - "The purpose of this study was to determine the efficacy of controlled-release (CR) melatonin in the treatment of delayed sleep phase syndrome and impaired sleep maintenance of children with neurodevelopmental disabilities including autistic spectrum disorders. " 12/30/1994 - "The present study objectively evaluated the efficacy of oral 5 mg day-1 melatonin in advancing the sleep-wake rhythm in patients with delayed sleep phase syndrome (DSPS). "
2.	modafinil (armodafinil)FDA Link 08/04/2005 - "Treatment with 200 mg of modafinil reduced the extreme sleepiness that we observed in patients with shift-work sleep disorder and resulted in a small but significant improvement in performance as compared with placebo. " 08/04/2005 - "In a three-month, double-blind trial, we randomly assigned 209 patients with shift-work sleep disorder to receive either 200 mg of modafinil or placebo before the start of each shift. " 01/01/2014 - "Both modafinil and armodafinil increase alertness and reduce sleepiness to some extent in employees who suffer from shift work sleep disorder but they are associated with adverse events. " 07/01/2011 - "Waking up to modafinil in shift work sleep disorder." 01/01/2011 - "To compare the efficacy and safety of armodafinil, the R-enantiomer of modafinil, with modafinil in patients of shift work sleep disorder (SWSD). "
3.	MT2 Melatonin ReceptorIBA 02/11/2000 - "Genetic polymorphisms of human melatonin 1b receptor gene in circadian rhythm sleep disorders and controls." 01/01/2006 - "In humans, appropriate clinical trials confirm the efficacy of melatonin or melatoninergic agonists for the MT1 and MT2 receptor subtypes in circadian rhythm sleep disorders only. " 11/01/2004 - "Ramelteon (TAK-375) is an MT1/MT2 receptor agonist being studied for the treatment of insomnia and circadian rhythm sleep disorders. "
4.	tasimelteonIBA 02/07/2009 - "Tasimelteon may have therapeutic potential for transient insomnia in circadian rhythm sleep disorders." 07/01/2009 - "Tasimelteon was effective in reducing sleep onset latency (in phase II and III clinical trials) and in resetting the circadian melatonin rhythm (in phase II trials), which indicated its potential suitability as treatment for jet lag, shift work and circadian rhythm sleep disorders. " 07/01/2009 - "Tasimelteon, a melatonin agonist for the treatment of insomnia and circadian rhythm sleep disorders." 02/01/2010 - "The agonists reviewed here - ramelteon, tasimelteon and agomelatine - all appear to be efficacious in the treatment of circadian rhythm sleep disorders and some types of insomnia. "
5.	S 20098 (agomelatine)IBA 01/01/2009 - "Moreover, agomelatine has been found to restore normal circadian rhythms in animal models of a disrupted circadian system, and has proved beneficial in an animal model of delayed sleep phase syndrome. " 09/01/2008 - "A resynchronizing activity of agomelatine was seen in animal models for delayed sleep phase syndrome and in several original models of circadian disturbance, such as rodents infected by trypanosome or old hamsters. " 09/01/1993 - "Successful use of S20098 and melatonin in an animal model of delayed sleep-phase syndrome (DSPS)." 02/01/2010 - "The agonists reviewed here - ramelteon, tasimelteon and agomelatine - all appear to be efficacious in the treatment of circadian rhythm sleep disorders and some types of insomnia. " 01/01/2007 - "The hypnotic and rhythm-regulating properties of melatonin and its agonists (ramelteon, agomelatine) make them an important addition to the armamentarium of drugs for treating primary and secondary insomnia and circadian rhythm sleep disorders."
6.	Carbon MonoxideIBA 01/01/2006 - "The negative consequences of shift work have been established, and recent evidence suggests that patients with shift work sleep disorder (SWSD) are at increased risk of these consequences and co-morbidities. " 01/01/2000 - "The treatment of sleep disorders caused by co-morbid conditions is discussed under seven categories, including the use of general measures (e.g., sleep hygiene, encouraging patients to develop good sleep habits, medication), treatment of the co-morbid condition, treatment of insomnia, treatment of excessive daytime somnolence, treatment of parasomnias, treatment of sleep-wake schedule disorders, and treatment of secondary or symptomatic restless legs syndrome." 07/01/1993 - "The co-occurrence of circadian rhythm sleep disorders with the deteriorated melatonin rhythm raised the question as to whether the sleep disorders of these subjects, like those of subjects with healthy brains, could be relieved by the induction of normal melatonin rhythm."
7.	mecobalamin (methylcobalamin)IBA 10/01/1997 - "The aim of this double-blind study was to investigate the efficacy of methylcobalamin on delayed sleep phase syndrome (DSPS). " 10/01/1991 - "Two adolescent patients suffering from persistent sleep-wake schedule disorders appear to have responded to treatment with vitamin B12 (methylcobalamin). " 10/01/1991 - "Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12)."
8.	aripiprazole (Abilify)FDA Link 07/01/2014 - "Aripiprazole is effective for treatment of delayed sleep phase syndrome."
9.	Triazolam (Halcion)FDA LinkGeneric 03/01/1989 - "A treatment trial of delayed sleep phase syndrome with triazolam." 03/01/1989 - "We attempted to treat two patients with delayed sleep phase syndrome (DSPS) with triazolam. "
10.	AntigensIBA 08/01/1999 - "The study investigated the human leucocyte antigen (HLA), types A, B and DR, of 42 patients with delayed sleep phase syndrome (DSPS) and compared the frequencies of the antigens with those in 117 healthy controls. " 08/01/1999 - "Possible association of human leucocyte antigen DR1 with delayed sleep phase syndrome."

Therapies and Procedures

1.	Phototherapy (Light Therapy) 01/01/2003 - "This study tested whether a newly designed enhanced evening light therapy was well tolerated and effective in relieving symptoms of Advanced, Sleep Phase Syndrome (ASPS). " 05/01/2011 - "Results from the present study suggest that for phototherapy of circadian rhythm sleep disorders in humans, a longer period of moderate intensity light may be more effective than a shorter exposure period of high intensity light." 03/01/2011 - "This plasticity has important implications for the optimization of light therapy for the treatment of circadian rhythm sleep disorders." 08/01/2008 - "In this article, we examine the physiological basis for bright light therapy, and we discuss the application of light in the treatment of circadian rhythm sleep disorders including advanced and delayed sleep-phase disorder, free-running disorder (nonentrained type), shiftwork disorder and jet lag disorder. " 02/01/2007 - "Delayed sleep phase syndrome, ADHD, and bright light therapy."
2.	Laparotomy 01/01/2002 - "Since disorders of the sleep-wake cycle have been reported to be one of the key factors in POD, we attempted to clarify the effectiveness of improving sleep-wake cycle disorders with medication after surgery to prevent POD, by conducting a prospective randomized study of 42 elderly patients who underwent resection of either gastric or colon cancer through an open laparotomy. "
3.	Chronotherapy 12/10/1992 - "Hypernyctohemeral syndrome after chronotherapy for delayed sleep phase syndrome." 01/01/1988 - "To clarify the circadian aspects of delayed sleep phase syndrome (DSPS) in 4 patients with DSPS, we recorded polysomnograms and rectal temperature before and after chronotherapy. " 01/01/2007 - "However, chronobiology disorders missed 97.6% of its pertinent articles; periodicity, 95.2%; chronobiology, 87.7%; chronotherapy, 70%; time factors, 62.3%; and sleep disorders/circadian rhythm, 47.4%. " 08/01/2014 - "Treatment of circadian rhythm sleep disorders (CRSD) may include light therapy, chronotherapy and melatonin. " 03/01/2002 - "In addition to the specific circadian rhythm sleep disorders, this review will also examine current drug (e.g., hypnotics and melatonin) and nondrug (e.g., bright light therapy and chronotherapy) treatments, the overlap with psychophysiological insomnia and future directions."
4.	Continuous Positive Airway Pressure 01/01/2008 - "narcolepsy, shift-work sleep disorder and obstructive sleep apnoea with residual excessive sleepiness despite optimal use of continuous positive airway pressure (CPAP). " 01/01/2003 - "Important innovations include the expansion of BSM beyond the treatment of insomnia to include treatment of pediatric sleep disorders, circadian rhythm disorders, parasomnias, as well as desensitization procedures for patients undergoing treatment with nasal continuous positive airway pressure (CPAP)." 10/01/2004 - "There is a growing school of thought that modafinil may have a role to play in other indications such as obstructive sleep apnea/hypopnea syndrome already treated by nasal continuous positive airway pressure but persisting EDS, shift work sleep disorders, neurological causes of sleepiness, and healthy adults performing sustained operations, particularly those in the military. " 08/01/2007 - "Modafinil (Provigil) is approved for treating excessive daytime sleepiness associated with narcolepsy, for shift-work sleep disorder, and as an adjunctive treatment in patients with obstructive sleep apnea syndrome who have residual daytime sleepiness despite optimal treatment with continuous positive airway pressure. "
5.	Off-Label Use 01/01/2011 - "Other potential off-label uses of ramelteon include circadian rhythm sleep disorders such as shift-work and jet lag. "