Idiopathic Hypersomnolence

A sleep disorder of central nervous system origin characterized by prolonged nocturnal sleep and periods of daytime drowsiness. Affected individuals experience difficulty with awakening in the morning and may have associated sleep drunkenness, automatic behaviors, and memory disturbances. This condition differs from narcolepsy in that daytime sleep periods are longer, there is no association with CATAPLEXY, and the multiple sleep latency onset test does not record sleep-onset rapid eye movement sleep. (From Chokroverty, Sleep Disorders Medicine, 1994, pp319-20; Psychiatry Clin Neurosci 1998 Apr:52(2):125-129)

Also Known As:

Networked: 56 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Narcolepsy
2.	Cataplexy
3.	Disorders of Excessive Somnolence (Hypersomnia)
4.	Sleep Apnea Syndromes (Sleep Apnea)
5.	Parkinson Disease (Parkinson's Disease)

Experts

1.	Mignot, Emmanuel: 5 articles (08/2015 - 01/2003)
2.	Inoue, Yuichi: 4 articles (08/2015 - 03/2002)
3.	Pizza, Fabio: 3 articles (08/2015 - 11/2009)
4.	Plazzi, Giuseppe: 3 articles (08/2015 - 11/2009)
5.	Nishino, Seiji: 3 articles (02/2009 - 03/2002)
6.	Vandi, Stefano: 2 articles (08/2015 - 02/2013)
7.	Gammeltoft, Steen: 2 articles (12/2014 - 09/2014)
8.	Bang-Berthelsen, Claus Heiner: 2 articles (12/2014 - 09/2014)
9.	Knudsen, Stine: 2 articles (12/2014 - 09/2014)
10.	Modvig, Signe: 2 articles (12/2014 - 09/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Idiopathic Hypersomnolence:

1.	modafinil (armodafinil)FDA Link 02/01/2015 - "Modafinil in the treatment of idiopathic hypersomnia without long sleep time--a randomized, double-blind, placebo-controlled study." 01/01/2015 - "Evaluation of the Effect of Modafinil on Cognitive Functions in Patients with Idiopathic Hypersomnia with P300." 06/01/2011 - "The benefit/risk ratio of modafinil was recently re-evaluated by the European Medicines Agency and was shown to be negative for idiopathic hypersomnia (IH) because of insufficient data. " 02/01/1998 - "Modafinil is also of great value in the treatment of idiopathic hypersomnia. " 03/01/2014 - "Modafinil improves driving performance in patients with narcolepsy and idiopathic hypersomnia. "
2.	orexins (orexin)IBA 09/01/2014 - "On the other hand, the etiology and pathophysiology of non-hypocretin-related hypersomnias (eg, idiopathic hypersomnia, Kleine-Levine syndrome) are unknown. " 12/15/2011 - "Female and male patients with narcolepsy and hypocretin deficiency had the highest mean BMI (27.8 and 26.2, respectively), not statistically different from patients with narcolepsy and normal hypocretin or controls, but statistically higher than the patients with idiopathic hypersomnia (p < 0.001 and 0.011, respectively). " 08/01/2015 - "One hundred seventy-five patients with hypocretin-deficient narcolepsy type 1 (NT1, n = 79), narcolepsy type 2 (NT2, n = 22), idiopathic hypersomnia (IH, n = 22), and "subjective" hypersomnolence (sHS, n = 52). " 12/15/2011 - "26 patients with narcolepsy, cataplexy, and hypocretin deficiency; 23 patients with narcolepsy, cataplexy, and normal hypocretin values; 11 patients with idiopathic hypersomnia; and 43 controls. " 11/01/2009 - "BMI-independent metabolic alterations and the relative hypophagia of patients with narcolepsy with cataplexy, as compared with patients with idiopathic hypersomnia without long sleep time, suggest that orexin-A influences the etiology of this phenotype. "
3.	STF 62247IBA 03/01/2009 - "The gold standard exam of narcolepsy with cataplexy is Hypocretin-1 dosage, but in patients without cataplexy and idiopathic hypersomnia, there are no specific diagnostic lab findings. "
4.	acetamideIBA 08/01/1996 - "Modafinil [(diphenyl-methyl)sulphinyl-2-acetamide] is a novel psychostimulant drug which is effective in the treatment of narcolepsy and idiopathic hypersomnia. "
5.	diphenyl (biphenyl)IBA 08/01/1996 - "Modafinil [(diphenyl-methyl)sulphinyl-2-acetamide] is a novel psychostimulant drug which is effective in the treatment of narcolepsy and idiopathic hypersomnia. "
6.	human HLA-DQB1 proteinIBA 03/01/2009 - "The present study describes the prevalence of HLA-DQB1*0602 allele in narcoleptics with and without cataplexy and in patients with idiopathic hypersomnia. " 03/01/2009 - "The prevalence of the HLA-DQB1*0602 allele was increased in idiopathic hypersomnia and in narcoleptic patients with and without cataplexy when compared to healthy subjects (p = 0.04; p = 0.03 and p < 0.0001, respectively). " 03/01/2009 - "Narcolepsy (with and without cataplexy) and idiopathic hypersomnia, are disorders with common features but with different HLA-DQB1*0602 allele prevalence. " 03/01/2009 - "Prevalence of the HLA-DQB1*0602 allele in narcolepsy and idiopathic hypersomnia patients seen at a sleep disorders outpatient unit in São Paulo." 01/01/2010 - "The distribution of serum IgG was significantly different among healthy controls negative for the HLA-DQB1*0602 allele (11.66+/-3.55 mg/ml), healthy controls positive for the HLA-DQB1*0602 allele (11.45+/-3.43), narcolepsy patients (9.67+/-3.38), and idiopathic hypersomnia patients (13.81+/-3.80). "
7.	tranilast (N 5')IBA 08/01/2012 - "Diagnoses according to ICSD-2 criteria were narcolepsy with (n=42) and without cataplexy (n=5), idiopathic hypersomnia without long sleep time (n=37), and obstructive sleep apnoea syndrome (n=12). " 05/01/1997 - "Ten Caucasian males (mean age, 66 years) with polygraphically confirmed RBD (n = 5, idiopathic RBD: n = 5, RBD with Parkinson's disease), but without narcolepsy, idiopathic hypersomnia, or autoimmune disease, were recruited for this study, along with 10 Caucasian male controls (mean age, 63 years) without a history of sleep disorder or autoimmune disease. " 01/01/2003 - "Diagnoses included classical narcolepsy (n=3), symptomatic narcolepsy (n=1), narcolepsy without cataplexy (n=4), idiopathic hypersomnia (n=5), hypersomnia associated with psychiatric disorders (n=5), and hypersomnia secondary to neurological disorders or of undetermined origin (n=9). "
8.	Thyroxine (Levothyroxine)FDA LinkGeneric 06/01/2011 - "Effect of levothyroxine on prolonged nocturnal sleep time and excessive daytime somnolence in patients with idiopathic hypersomnia." 03/01/2009 - "Our objective was to discuss the effect of levothyroxine on excessive daytime sleepiness (EDS) and a prolonged nocturnal sleep at patients with idiopathic hypersomnia who presented with subclinical hypothyroidism. " 03/01/2009 - "Successful treatment with levothyroxine for idiopathic hypersomnia patients with subclinical hypothyroidism." 06/01/2011 - "This study aims to examine the effect of levothyroxine, a thyroid hormone, on a prolonged nocturnal sleep and excessive daytime somnolence (EDS) in patients with idiopathic hypersomnia. "
9.	CytokinesIBA 03/01/2002 - "Sleepiness and fatigue are very prevalent in the general population, and recent studies have demonstrated that the proinflammatory cytokines IL-6 and/or TNF-alpha are elevated in disorders associated with excessive daytime sleepiness, such as sleep apnea, narcolepsy, and idiopathic hypersomnia. "
10.	Interleukin-6 (Interleukin 6)IBA 03/01/2002 - "Sleepiness and fatigue are very prevalent in the general population, and recent studies have demonstrated that the proinflammatory cytokines IL-6 and/or TNF-alpha are elevated in disorders associated with excessive daytime sleepiness, such as sleep apnea, narcolepsy, and idiopathic hypersomnia. "

Therapies and Procedures

1.	Cardiopulmonary Resuscitation (CPR) 01/01/1996 - "Mean sleep latency test (MSLT) and continuous polysomnographic recording (CPR) were done in 12 dysthymic patients, in comparison with 12 idiopathic hypersomnia patients, and 12 normal controls. "
2.	Drug Therapy (Chemotherapy) 12/15/2009 - "We describe various clinical and polysomnographic features of patients with idiopathic hypersomnia, with an emphasis on response to pharmacotherapy. "
3.	Anesthesia 07/01/1986 - "[Idiopathic hypersomnia and anesthesia]."