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Caspase 1 (ICE Protease)

A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.

Also Known As:

ICE Protease; CASP1 Caspase; IL-1 beta Convertase; IL1BC Enzyme; Interleukin-1 Converting Enzyme; Pro-Caspase-1; Procaspase-1; Caspase, CASP1; Convertase, IL-1 beta; Converting Enzyme, Interleukin-1; Converting Enzyme, Interleukin-1beta; IL 1 beta Convertase; IL 1 beta Converting Enzyme; Interleukin 1 Converting Enzyme; Interleukin 1beta Converting Enzyme; Pro Caspase 1; Procaspase 1; beta Convertase, IL-1; beta-Converting Enzyme, IL-1; IL-1 beta-Converting Enzyme; Interleukin-1beta Converting Enzyme

Networked: 257 relevant articles (11 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kanneganti, Thirumala-Devi: 8 articles (06/2015 - 12/2008)
2.	Netea, Mihai G: 6 articles (06/2015 - 12/2009)
3.	Lamkanfi, Mohamed: 5 articles (03/2015 - 12/2004)
4.	Stienstra, Rinke: 4 articles (06/2015 - 04/2010)
5.	Joosten, Leo A B: 4 articles (01/2011 - 12/2009)
6.	Heymann, Michael C: 3 articles (07/2015 - 01/2013)
7.	Hofmann, Sigrun R: 3 articles (07/2015 - 01/2013)
8.	Luksch, Hella: 3 articles (07/2015 - 01/2013)
9.	Roesler, Joachim: 3 articles (07/2015 - 01/2013)
10.	Winkler, Stefan: 3 articles (07/2015 - 01/2013)

Related Diseases

1.	Inflammation 01/01/2011 - "The aim of this study was to determine whether activation of the P2X7/caspase 1 pathway has a functional role in CS-induced airway inflammation. " 10/01/2008 - "Lacrimal gland inflammation was induced by injection of lipopolysaccharide (LPS; to study the role of caspase 1) or IL-1beta (to study the role of ERK). " 04/24/2007 - "The crucial role of IL-1beta in inflammation has been further highlighted by studies of mice lacking caspase 1 (casp1, also known as IL-1beta convertase), a protease that cleaves pro-IL-1beta into mature IL-1beta. " 07/01/2015 - "In addition, homotypic CARD/CARD interaction of procaspase-1 with RIP2 and thereby activation of the NF-κB pathways may play some role in the inflammation. " 05/01/2014 - "Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-κB signaling."
2.	Anoxia (Hypoxia) 05/31/2013 - "Here we demonstrate that caspase 1 activation protects against cell death after redox stress induced by hypoxia/reoxygenation in hepatocytes. " 10/03/2012 - "Mechanistically, hypoxia/reoxygenation more than doubled caspase 1 activity in the brain, which was localized to the amygdala compared to the hippocampus. " 04/01/2007 - "PT from caspase-1-/-mice demonstrated less hypoxia-induced membrane injury. " 12/23/2003 - "Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death." 05/31/2013 - "Mechanistically, we show that caspase 1 reduces mitochondrial respiration and reactive oxygen species by increasing mitochondrial autophagy and subsequent clearance of mitochondria in hepatocytes after hypoxia/reoxygenation. "
3.	Ischemia 05/27/2005 - "These data demonstrate that the proapoptotic effects of caspase-1 can significantly impact the myocardial response to ischemia and suggest that conditions in which procaspase-1 in the heart is increased may predispose to apoptotic myocardial injury under conditions of physiological stress." 10/25/2004 - "Both caspase-1 and -3 inhibitors markedly reduced the evidence of oxidative and nitrosative stress in rat kidneys subjected to ischemia-reperfusion. " 03/27/2001 - "Caspase-1-/-, caspase-1+/+ as well as Swiss mice were subjected to 45 min of renal ischemia and 24 hr of reperfusion. " 04/01/2014 - "This editorial discusses a new molecule 16673-34-0 that inhibits the NLRP3 inflammasome and decreases caspase 1 production following ischemia reperfusion or acute peritonitis in mice." 12/23/2003 - "Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death."
4.	Sepsis (Septicemia) 06/01/2015 - "Improved emergency myelopoiesis and survival in neonatal sepsis by caspase-1/11 ablation." 01/01/2014 - "The aim of the present study is to evaluate whether sepsis activates NLRP3 inflammasome/caspase-1/IL-1β pathway in cardiac fibroblasts (CFs) and whether this cytokine can subsequently impact the function of cardiomyocytes (cardiac fibroblast-myocyte cross-talk). " 06/01/2015 - "These findings suggest that endogenous caspase-1/11 activity, independent of the NLRP3 inflammasome, not only promotes the magnitude of the inflammatory response, but also suppresses protective immunity in the neonate, so contributing to innate immune dysfunction and poor survival in neonatal sepsis." 06/01/2015 - "Neonatal (5-7 days) C57BL/6 and caspase-1/11(-/-) mice underwent a low-lethality caecal slurry model of intra-abdominal sepsis (LD25-45 ). " 01/01/2011 - "These data demonstrate that the inhibition of caspase-1 and defective IL-1 β production is an important immunological feature in sepsis."
5.	Infection 02/01/2004 - "In contrast, LM-specific acquired immunity in caspase-1(-/-) mice was normal and they successfully cleared the pathogen following secondary infection, in spite of a moderate skewing of cytokine profile to T(h)2 when compared to wild-type mice. " 06/24/2014 - "Two caspase 1 inhibitors had no effect on productive infection. " 06/24/2014 - "During productive infection, more than ten times more cells were caspase 1 positive, which is activated following inflammasome formation. " 06/24/2014 - "Bovine herpesvirus 1 productive infection stimulates inflammasome formation and caspase 1 activity." 05/01/2014 - "ASC and caspase 1/11 KO animals were exquisitely sensitive, with approximately 50% of mice succumbing to infection within 24 h. "

Related Drugs and Biologics

1.	Interleukin-18 (Interleukin 18)
2.	Caspase 1 (ICE Protease)
3.	Ice
4.	Carbon Monoxide
5.	Toll-Like Receptor 4
6.	Reactive Oxygen Species (Oxygen Radicals)
7.	Etorphine (M99)
8.	Dactinomycin (Ac-De)
9.	Antibodies
10.	2- chloro- N(6)- (3- iodobenzyl)- 5'- N- methylcarboxamidoadenosine (Cl-IB-MECA)

Related Therapies and Procedures

1.	Resuscitation
2.	Spinal Injections
3.	Injections
4.	Therapeutics
5.	Transplants (Transplant)