Caspases

A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.

Networked: 1746 relevant articles (30 outcomes, 143 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lee, Chung Soo: 14 articles (08/2015 - 12/2010)
2.	Vandenabeele, Peter: 11 articles (02/2014 - 06/2004)
3.	Kim, Yun Jeong: 10 articles (12/2014 - 12/2010)
4.	Saleh, Maya: 10 articles (04/2014 - 05/2004)
5.	Reed, John C: 10 articles (04/2013 - 10/2002)
6.	Choi, Yung Hyun: 10 articles (10/2011 - 12/2003)
7.	Salvesen, Guy S: 9 articles (11/2015 - 01/2002)
8.	Lamkanfi, Mohamed: 8 articles (03/2015 - 06/2004)
9.	Rohn, Troy T: 8 articles (07/2011 - 11/2002)
10.	Troy, Carol M: 7 articles (01/2015 - 02/2005)

Related Diseases

1.	Neoplasms (Cancer) 07/10/2015 - "Taken together, our data elaborate the role of Bak in caspase/Bax-independent cell death and suggest that PL may be an effective agent for overcoming chemoresistance in cancer cells with dysfunctional caspases. " 06/28/2001 - "Bcl-2 overexpression in these cells blocked activation of these caspases, suggesting that bcl-2 expression of human cancer cells may be a critical factor in the therapeutic efficacy of TRAIL." 10/01/1999 - "This may prove useful in the treatment of tumors that are resistant to therapeutic agents that are dependent on the activation of p53 and/or caspases." 10/13/2015 - "In this study, we report that B5 induces apoptosis in two human cervical cancer cell lines, CaSki and SiHa, as evidenced by the downregulation of XIAP, activation of caspases and cleavage of PARP. " 12/01/2014 - "This is a novel study comprising the expression study of HER2 and different caspases in different cancer cell lines simultaneously. "
2.	Necrosis 03/01/2009 - "Recently, many studies have subdivided PCD into the three categories: apoptosis, autophagy, and programmed necrosis, based on criteria such as morphological alterations, initiating death signal, and the activation of caspases. " 05/01/2008 - "As the study of caspase-independent programs has expanded, it has become increasingly apparent that this pathway is not simply an alternative to apoptosis when caspases are unavailable, but a unique process, distinct from both apoptosis and necrosis. " 02/01/2005 - "Many studies have subdivided PCD into the three categories of apoptosis, autophagy, and necrosis based on criteria such as morphological alterations, initiating death signal, or the implication of caspases. " 08/01/2002 - "Although caspases are known to be involved in apoptosis, the present study examined whether caspases also play a role in NO-induced CMC necrosis. " 07/01/2015 - "Fas, tumour necrosis factor receptor) and caspases (e.g., caspase-6, caspase-7, caspase-9), suggesting activation of the apoptosis pathway. "
3.	Inflammation 10/01/2000 - "Elucidation of the important role of caspases in eosinophil apoptosis may facilitate the development of more specific and effective treatment for allergic inflammation." 11/01/2014 - "Recent studies on necroptosis however demonstrated that also inhibition of caspases can cause barrier dysfunction and intestinal inflammation. " 01/01/2011 - "It has become evident that many caspases also function in other signaling pathways that propagate cell proliferation and inflammation, but studies on the inflammatory function of caspases have mainly been limited to caspase-1-mediated cytokine processing. " 03/01/2009 - "Furthermore, recent studies suggest that caspases are also involved in inflammation and cellular differentiation in mammals. " 05/16/2006 - "Together, these studies show a general small-molecule-binding site for functionally reversing the zymogen activation of caspases and suggest a common regulatory site for the allosteric control of inflammation and apoptosis."
4.	Breast Neoplasms (Breast Cancer) 10/01/2011 - "These results suggest that caspases represent a novel target for drugs that increase the therapeutic efficacy of oncolytic herpes viruses against breast cancer." 01/01/2011 - "In the present study, we could find that treatment of breast cancer MCF-7 cells with FR led to apoptosis accompanying with apparent activation of caspases. " 05/01/2008 - "There are very few studies on the final triggers of apoptosis, the caspases, in breast cancer. " 01/01/2015 - "We demonstrate that chronic and low doses of AEs treatment at sublethal concentrations suppress human breast cancer cell growth via a caspases-independent mechanism. " 01/01/2015 - "Additionally, Nar altered the expression of apoptosis and cell-cycle regulatory genes by down-regulating Cdk4, Cdk6, Cdk7, Bcl2, x-IAP and c-IAP-2 and up-regulating p18, p19, p21, caspases 3, 7, 8 and 9, Bak, AIF and Bax in both colorectal and breast cancer cells. "
5.	Ischemia 10/25/2004 - "Furthermore, our finding that a pan-caspase inhibitor did not reduce the renal dysfunction and injury suggests that activation of some caspases during ischemia-reperfusion could provide protection against acute ischemic renal injury. " 03/10/2008 - "These studies demonstrate conclusively that orally administered EGCG attenuates injury to the retina caused by ischemia/reperfusion where caspases were activated. " 01/01/2008 - "The precise mechanism underlying HtrA2-induced apoptosis in mammalian cells has been studied through biochemical, structural, and genetic studies, in which HtrA2 promotes proteolytic activation of caspases through multiple pathways in heart ischemia. " 07/01/2005 - "The aim of this study was to show that broad-scale inhibition of caspases, the main executioners of apoptosis, improves functional outcome after ischemia and reperfusion in an in vivo model. " 08/01/2002 - "This study compared the timing, location, and relative activity of calpains and caspases in the adult rat brain following 10 min of transient forebrain ischemia. "

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)
2.	Proteins (Proteins, Gene)
3.	Reactive Oxygen Species (Oxygen Radicals)
4.	NF-kappa B (NF-kB)
5.	Cytochromes c (Cytochrome c)
6.	Peptide Hydrolases (Proteases)
7.	Phosphotransferases (Kinase)
8.	Death Domain Receptors
9.	Etoposide (VP 16)
10.	Caspase 9

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Aftercare (After-Treatment)
4.	Resuscitation
5.	Chinese Traditional Medicine (Traditional Chinese Medicine)