Sodium Benzoate

05/01/1983 - "Although sodium benzoate offers considerable promise for the treatment of hyperammonemia, toxicity appears likely in some infants receiving this drug in currently recommended doses. "
01/07/1993 - "Effect of sodium benzoate on cerebral and hepatic energy metabolites in spf mice with congenital hyperammonemia."
12/01/1989 - "It is recommended that methylsuccinate-free sodium benzoate should be used for the treatment of hyperammonemia."
12/01/1989 - "Of the two unusual substances, methylsuccinate was found to be a contaminant of sodium benzoate administered for the treatment of hyperammonemia. "
10/01/1988 - "Our results warrant a reevaluation of the use of sodium benzoate in the treatment of hyperammonemia."

07/01/2023 - "In conclusion, sodium benzoate may be effective among patients with schizophrenia or depression; however, the mechanisms of actions remain to be elucidated."
02/01/2022 - "Sodium benzoate can improve the positive symptoms of schizophrenia without any beneficial effect on other symptomatology, cognition, quality of life and functioning. "
02/01/2022 - "Add-on sodium benzoate can improve positive symptoms of schizophrenia significantly (MD: -1.87; 95%CI: -3.25 to -0.48; p = 0.008) but had no significant favourable effect on negative symptoms (p = 0.84), general psychopathology (p = 0.49), and total PANSS score (p = 0.19) over the control. "
02/01/2022 - "The present meta-analysis has evaluated the efficacy and safety of add-on sodium benzoate for the treatment of schizophrenia. "
12/13/2021 - "Sodium benzoate, a common food preservative holds potential to be an effective, accessible treatment for schizophrenia, though the optimal dosing and mechanism of action of the compound requires further investigation. "

10/24/2023 - "To elucidate the potential mechanisms of sodium benzoate in Alzheimer's disease, this study employed label-free quantitative proteomics to analyze serum samples from AD cohorts with and without sodium benzoate treatment. "
01/01/2015 - "This study underlines the importance of cinnamon, a commonly used natural spice and flavoring material, and its metabolite sodium benzoate (NaB) in attenuating oxidative stress and protecting memory and learning in an animal model of Alzheimer's disease (AD). "
10/24/2023 - "Elucidating the Mechanisms of Sodium Benzoate in Alzheimer's Disease: Insights from Quantitative Proteomics Analysis of Serum Samples."
01/01/2015 - "Cinnamon and Its Metabolite Sodium Benzoate Attenuate the Activation of p21rac and Protect Memory and Learning in an Animal Model of Alzheimer's Disease."
05/01/2014 - "Sodium benzoate produced a better improvement than placebo in Alzheimer's Disease Assessment Scale-cognitive subscale (p = .0021, .0116, and .0031 at week 16, week 24, and endpoint, respectively), additional cognition composite (p = .007 at endpoint) and Clinician Interview Based Impression of Change plus Caregiver Input (p = .015, .016, and .012 at week 16, week 24, and endpoint, respectively). "

07/01/1992 - "A prospective randomized double-blind study was conducted to evaluate the efficacy of sodium benzoate in the treatment of acute portal-systemic encephalopathy. "
07/01/1992 - "Sodium benzoate in the treatment of acute hepatic encephalopathy: a double-blind randomized trial."
04/01/2013 - "Sodium benzoate for treatment of hepatic encephalopathy."
03/01/2005 - "Sodium benzoate (SB) is a chemical substance that is used for preparing food and drinks and in the treatment of some metabolic (urea cycle disorders and hepatic coma) diseases. "
12/01/1994 - "Sodium benzoate and lactulose for the treatment of hepatic encephalopathy."

01/01/2020 - "More studies are warranted to elucidate the mechanisms of sodium benzoate for the treatment of schizophrenia and the etiology of this severe brain disease. "
07/01/1992 - "We conclude that sodium benzoate is a safe and effective alternative to lactulose in the treatment of acute portasystemic encephalopathy."
04/01/2004 - "After treatment with sodium benzoate and dextromethorphan, the patient's encephalopathy resolved and her chorea improved. "
12/01/2011 - "Hepatic encephalopathy management also consists of three main aspects: (i) ruling out other causes of encephalopathy; (ii) identifying and treating precipitating factors; and (iii) starting empiric treatment with drugs such as lactulose, rifaximin, sodium benzoate, and flumazenil. "
03/01/2014 - "In this review, we provide a targeted overview of the mechanisms and availability of five anti-ammoniagenic compounds (sodium phenylbutyrate, glycerol phenylbutyrate, sodium benzoate, L-ornithine L-aspartate, and ornithine phenylacetate) identified as possibly useful alternative therapeutic agents for cirrhotic encephalopathy. "