Salicylic Acid (2 Hydroxybenzoic Acid)

A compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics. (From Dorland's, 28th ed)

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Networked: 1190 relevant articles (81 outcomes, 114 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Hwang, Byung Kook: 10 articles (06/2014 - 06/2005)
2.	Klessig, Daniel F: 6 articles (04/2015 - 02/2004)
3.	Greenberg, Jean T: 6 articles (04/2015 - 02/2004)
4.	Uhrich, Kathryn E: 6 articles (03/2015 - 03/2005)
5.	Zhang, Huijuan: 6 articles (01/2015 - 11/2008)
6.	Song, Fengming: 6 articles (01/2015 - 11/2008)
7.	Carr, John P: 6 articles (09/2014 - 02/2002)
8.	Seo, Shigemi: 6 articles (12/2013 - 03/2002)
9.	Shah, Jyoti: 5 articles (10/2015 - 07/2012)
10.	Jung, Ho Won: 5 articles (04/2015 - 06/2005)

Related Diseases

1.	Acne Vulgaris 03/01/2006 - "Salicylic acid peels are beneficial in whitening the face of Asian patients with acne. " 12/01/2015 - "Comparing the therapeutic efficacy of TCA 25% peels with those of salicylic acid 30% in patients with acne vulgaris. " 12/01/2003 - "Salicylic acid peels are an effective and safe therapy for acne vulgaris in Asian patients." 05/01/2013 - "This study investigates the safety and efficacy of an antioxidant optimized topical salicylic acid (SA) 1.5% cream containing natural skin penetration enhancers in combination with antioxidant activity for treatment of facial acne. " 01/01/2015 - "Our primary objective was to evaluate the safety and efficacy of concurrent use of salicylic acid peels with PDL versus salicylic acid peels alone in the treatment of moderate to severe acne vulgaris. "
2.	Warts (Wart) 12/15/2012 - "It is a more effective cure for common warts than salicylic acid or observation. " 01/01/2012 - " of salicylic acid (SA) versus placebo showed that the former significantly increased the chance of clearance of warts at all sites (RR (risk ratio) 1.56, 95% CI (confidence interval) 1.20 to 2.03). " 01/01/1989 - "A clinical study was conducted to evaluate the efficacy of a new delivery system for administering salicylic acid for the treatment of verruca vulgaris. " 10/01/2014 - "as a method of ITM, versus salicylic acid in treatment of wart. " 10/01/2014 - "Versus Salicylic Acid for Wart Treatment."
3.	Psoriasis (Pustulosis Palmaris et Plantaris) 08/01/2013 - "To evaluate the therapeutic efficacy of topical 20% alpha-hydroxy/polyhydroxy acid versus standard salicylic acid to reduce scaling in patients with moderate, chronic psoriasis. " 08/01/2013 - "Twenty-five subjects with moderate, chronic psoriasis were enrolled in a 2-week, double-blind, left-right, randomized, bilateral comparison clinical trial to compare the efficacy of 20% alpha-hydroxy/polyhydroxy acid emollient versus 6% salicylic acid cream and 24 were randomized/completed. " 08/01/2013 - "Salicylic acid is a topical keratolytic agent used to reduce scaling and hyperkeratosis associated with psoriasis vulgaris. " 07/01/2011 - "The developed microemulsion gel containing BD and salicylic acid provided sustained and good anti-inflammatory activity for the treatment of psoriasis." 03/01/2011 - "Salicylic acid 6% emollient foam provides a useful option in the treatment of psoriasis that is highly effective, well tolerated and acceptable to patients."
4.	Infection 06/01/1977 - "Best results in fungus infection of the ear was obtained by daily packing of the external meatus by a wick of gauze soaked in 2% salicylic acid in alcohol (70%) for a few days after removal of the fungal mass." 08/01/2010 - "Conversely, over-expression of AtCPK1 leads to accumulation of salicylic acid (SA) and constitutive expression of SA-regulated defence and disease resistance genes, which, in turn, results in broad-spectrum protection against pathogen infection. " 11/02/2015 - "Our recent study suggests that salicylic acid (SA) is the primary phytohormone regulating plant responses to Agrobacterium tumefaciens infection. " 05/26/2008 - "In this study, morphological, ultrastructural and physiological modifications of faba bean (Vicia faba cv Giza 461) leaves in response to bean yellow mosaic virus (BYMV) infection and salicylic acid (SA) treatments were examined. " 11/01/2015 - "We used genetic, biochemical, pharmacological approaches in combination with infection experiments to investigate the NO-triggered salicylic acid (SA)-dependent defense response in Arabidopsis thaliana. "
5.	Ulcerative Colitis 07/02/1983 - "Maintenance of remission in ulcerative colitis with 5-amino salicylic acid in high doses by mouth." 03/01/2014 - "Effects of 5-amino salicylic acid on the expression of multidrug resistance gene in ulcerative colitis." 11/01/2004 - "In the present work, we aimed to analyse the effects and underlying molecular mechanisms of 5-amino salicylic acid (5-ASA) and derivatives on apoptosis of LPL and peripheral blood lymphocytes (PBL) in patients with CD compared with ulcerative colitis (UC) and in non-inflammatory controls. " 12/01/1998 - "5-[4-(2-Carboxyethylcarbamoyl)phenylazo]salicylic acid disodium salt dihydrate (CAS 80573-04-2, BX661A) is developed as a therapeutic agent for ulcerative colitis. " 11/01/1998 - "5-[4-(2-Carboxyethylcarbamoyl)phenylazo]salicylic acid disodium salt dihydrate (CAS 80573-04-2, BX661A) is being developed as a therapeutic drug for ulcerative colitis. "

Related Drugs and Biologics

1.	Benzoyl Peroxide
2.	Fluorouracil (Carac)
3.	Aspirin (Acetylsalicylic Acid)
4.	Retinoids
5.	calcipotriene (calcipotriol)
6.	glycolic acid (glycolate)
7.	Clindamycin (Cleocin)
8.	Adrenal Cortex Hormones (Corticosteroids)
9.	betamethasone-17,21-dipropionate (betamethasone dipropionate)
10.	Coal Tar (Estar)

Related Therapies and Procedures

1.	Cryotherapy (Therapy, Cold)
2.	Dye Lasers
3.	Cryosurgery
4.	Skin Care
5.	Excimer Lasers