Manganese Poisoning

Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. Clinical features include CONFUSION; HALLUCINATIONS; and an extrapyramidal syndrome (PARKINSON DISEASE, SECONDARY) that includes rigidity; DYSTONIA; retropulsion; and TREMOR. (Adams, Principles of Neurology, 6th ed, p1213)

Also Known As:

Poisoning, Manganese; Manganese Neurotoxicity Syndrome; Manganese Neurotoxicity Syndromes; Nervous System Diseases, Manganese Induced; Neurotoxicity Syndromes, Manganese; Syndrome, Manganese Neurotoxicity; Syndromes, Manganese Neurotoxicity; Nervous System Diseases, Manganese-Induced; Nervous System Poisoning, Manganese; Neurotoxicity Syndrome, Manganese

Networked: 83 relevant articles (2 outcomes, 11 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Parkinson Disease (Parkinson's Disease)
2.	Dyskinesias (Dyskinesia)
3.	Parkinsonian Disorders (Parkinsonism)
4.	Neurodegenerative Diseases (Neurodegenerative Disease)
5.	Poisoning

Experts

1.	Zhao, L: 2 articles (03/2021 - 12/2018)
2.	Chen, Cengceng: 2 articles (12/2018 - 12/2018)
3.	Guo, Shuhan: 2 articles (12/2018 - 12/2018)
4.	Tian, Yutian: 2 articles (12/2018 - 12/2018)
5.	Yan, Yongjian: 2 articles (12/2018 - 12/2018)
6.	Zhao, Li: 2 articles (12/2018 - 12/2018)
7.	Yang, Bo-ning: 2 articles (06/2013 - 03/2010)
8.	Hirata, Yoko: 2 articles (10/2009 - 09/2002)
9.	Chen, Dechun: 1 article (05/2022)
10.	Huang, Bin: 1 article (05/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Manganese Poisoning:

1.	Levodopa (L Dopa)FDA LinkGeneric 08/01/1975 - "Recently the prognosis of victims of manganese poisoning has been improved dramatically by the introduction of levodopa as a therapeutic agent." 06/01/1969 - "[L-Dopa in the management of chronic manganese poisoning]." 01/01/1992 - "The [11C]-L-dopa decarboxylation was not significantly altered indicating a sparing of [11C]-L-dopa decarboxylation during manganese poisoning. " 01/31/1970 - "L-dopa in chronic manganese poisoning." 06/01/2007 - "Levodopa therapy is not effective for the management of manganese poisoning. "
2.	ManganeseIBA 12/20/2018 - "Objective: To investigate the functional classification of differentially expressed genes in manganese-poisoned rats and related metabolic pathways, and to provide a reference for the study of the mechanism of manganese poisoning and gene regulation in the prevention and treatment of manganese poisoning. " 01/01/1986 - "Chronic manganese poisoning: a neuropathological study with determination of manganese distribution in the brain." 11/01/1957 - "[Manganese poisoning; clinical & environmental study in a manganese mine]." 12/20/2018 - "Conclusion: The differentially expressed genes in manganese-poisoned rats may influence the susceptibility to manganese poisoning through the PI3K-Akt pathway, mTOR metabolic pathway, or FoxO metabolic pathway, and may be involved in behavioral changes. " 10/01/2015 - "Long-term occupational exposure to manganese might cause manganese poisoning, which would had adverse effects on nervous system of workers. "
3.	Edetic Acid (EDTA)FDA Link 01/01/1956 - "Ethylenediaminetetraacetic acid in manganese poisoning of rats; a preliminary study." 03/01/1960 - "[Trials and results of the treatment of patients with manganese poisoning and of the prevention of manganese poisoning by EDTA calcium or calcitetracemate disodium]." 12/01/1957 - "I. Effect of EDTA calcium disodium on the precipitation of manganese in experimental manganese poisoning in rats]."
4.	Dopamine (Intropin)FDA LinkGeneric 12/01/2018 - "Sgk1, HCRTr1, HspB1, Rem2, Oprd1, ATF5, and TRHr identified in this study may be involved in oxidative stress mechanisms, dopamine (DA) synthesis, and neuronal survival during apoptosis and may affect susceptibility to manganese poisoning." 10/19/2009 - "Chronic manganese poisoning shares many features of Parkinson's disease, and also induces extrapyramidal syndromes that resemble those of Parkinson's disease due to dopamine depletion in the central nervous system. " 01/01/1995 - "Autoreceptor presynaptic control of dopamine release from striatum is lost at early stages of manganese poisoning." 09/01/2002 - "Dopamine deficiency has been demonstrated in Parkinson's disease and in chronic manganese poisoning, suggesting that the mechanisms underlying the neurotoxic effects of the metal ion are related to dysfunction of the extrapyramidal system. " 10/01/1998 - "A dopamine deficiency has been demonstrated in Parkinson's disease and in chronic manganese poisoning, suggesting that the mechanisms underlying the neurotoxic effects of the metal ion are related to a functional abnormality of the extrapyramidal system. "
5.	CalciumIBA 03/01/1960 - "[Trials and results of the treatment of patients with manganese poisoning and of the prevention of manganese poisoning by EDTA calcium or calcitetracemate disodium]." 01/01/1954 - "[Detoxicating effects of ethylenediamine tetraacetate of calcium in experimental manganese poisoning]." 12/01/1957 - "I. Effect of EDTA calcium disodium on the precipitation of manganese in experimental manganese poisoning in rats]." 01/01/1979 - "[Blood plasma level of iron, copper, zinc, magnesium and calcium in chronic experimental manganese poisoning]."
6.	IronIBA 01/01/1991 - "[Study of a series of enzyme systems and ultrastructure of rat liver in iron-manganese poisoning]." 12/01/1986 - "[Effect of manganese poisoning on the levels of manganese and iron in rat viscera]." 01/01/1979 - "[Blood plasma level of iron, copper, zinc, magnesium and calcium in chronic experimental manganese poisoning]."
7.	Glutathione (Reduced Glutathione)IBA 01/01/1965 - "[Studies on reduced glutathione of erythrocytes in experimental acute manganese poisoning]." 01/01/1966 - "Reduced glutathione of erythrocytes in acute experimental manganese poisoning."
8.	EnzymesIBA 03/29/1965 - "[THE BEHAVIOR OF LIVER ENZYMES IN EXPERIMENTAL MANGANESE POISONING]." 01/01/1991 - "[Study of a series of enzyme systems and ultrastructure of rat liver in iron-manganese poisoning]."
9.	Thiamine (Aneurin)FDA Link 01/01/1973 - "[Animal experimental studies on manganese poisoning and on the effect of thiamine on chronic manganese exposure]."
10.	Polysaccharides (Glycans)IBA 03/01/2010 - "To study the effect of Lycium barbarum polysaccharides (LBP) on neurogenesis and learning & memory of manganese poisoning mice. " 03/01/2010 - "[Effect of Lycium barbarum polysaccharides on neurogenesis and learning & memory in manganese poisoning mice]."

Therapies and Procedures

1.	Therapeutics 06/01/1971 - "[Pathogenesis and therapy of manganese poisoning (review)]." 06/01/2007 - "Levodopa therapy is not effective for the management of manganese poisoning. " 01/01/1964 - "[ON THE THERAPY OF CHRONIC MANGANESE POISONING WITH CHELATING AGENTS]." 03/05/1986 - "These data indicate that the alterations of dopaminergic postsynaptic receptors may be different in parkinsonian and in manganese-intoxicated patients and that current therapy used for Parkinson's disease could be a hazard in treating manganese poisoning."
2.	Intraperitoneal Injections 12/01/2018 - "Intraperitoneal injection of MnCl2·H2O (25 mg/kg) can successfully establish a manganese poisoning rat model with low mortality rate. " 06/01/2013 - "The mouse model of manganese poisoning was established by intraperitoneal injection of manganese chloride. "
3.	Intravenous Infusions 01/01/1992 - "Two cases of chronic manganese poisoning were treated with sodium para-aminosalicylic acid (PAS-Na; 6 g/day in 500 ml of 10% glucose solution by intravenous drip). "
4.	Renal Dialysis (Hemodialysis) 07/01/2016 - "We present a unique case of acute intravenous manganese poisoning with a systematic evaluation of hemodialysis efficacy. "