Genetic Anticipation

The apparent tendency of certain diseases to appear at earlier AGE OF ONSET and with increasing severity in successive generations. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

Also Known As:

Networked: 22 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Schizophrenia (Dementia Praecox)
2.	Myotonic Dystrophy (Dystrophia Myotonica)
3.	Mood Disorders (Mood Disorder)
4.	Fragile X Syndrome (Martin Bell Syndrome)
5.	Mental Retardation (Idiocy)

Experts

1.	Austin, Eric D: 2 articles (11/2012 - 08/2009)
2.	Phillips, John A: 2 articles (11/2012 - 08/2009)
3.	Loyd, James E: 2 articles (11/2012 - 08/2009)
4.	Tokuda, Takahiko: 2 articles (09/2007 - 06/2004)
5.	Hemnes, Anna R: 1 article (11/2012)
6.	Newman, John H: 1 article (11/2012)
7.	Robbins, Ivan M: 1 article (11/2012)
8.	West, James D: 1 article (11/2012)
9.	Larkin, Emma K: 1 article (11/2012)
10.	Hamid, Rizwan: 1 article (11/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Genetic Anticipation:

1.	DNA (Deoxyribonucleic Acid)IBA 01/01/2009 - "We could not find any evidence for either of the two currently known molecular mechanisms for genetic anticipation (i.e., expansion of repetitive DNA elements or progressive telomere shortening) in this family. " 02/01/1995 - "All available evidence suggests that this unstable trinucleotide repeat DNA is the biological basis of the clinical phenomenon of genetic anticipation. " 01/01/1995 - "All available evidence suggests that these expanded trinucleotide repeats, or unstable DNA, are the biological basis of the clinical phenomenon of genetic anticipation. " 10/01/1996 - "Search for unstable DNA in schizophrenia families with evidence for genetic anticipation." 09/01/1996 - "Demonstration of genetic anticipation in schizophrenia could be of heuristic value, since unstable trinucleotide repeat DNA is known to be the biological basis of anticipation. "
2.	Proteins (Proteins, Gene)IBA 01/01/1997 - "The topics discussed are: (1) the phenotype of the mutation (including appearance, behavioural changes and mental retardation) and its cytogenetic features, (2) examples and hypotheses of atypical inheritance (genetic anticipation, Sherman paradox and X-inactivation-dependent mechanism giving rise to this disease), (3) molecular studies (the expansion of the CGG repeat as the cause of the instability of the fragile X chromosome), (4) the FMRI gene - its possible role, expression and proteins and (5) diagnosis and tests of the fragile X syndrome."
3.	Idiopathic pulmonary hypertensionIBA 11/01/2012 - "Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension." 06/01/1997 - "The presence of genetic anticipation suggests that the molecular basis of familial primary pulmonary hypertension may be trinucleotide repeat expansion." 07/01/1995 - "Genetic anticipation and abnormal gender ratio at birth in familial primary pulmonary hypertension." 11/01/2012 - "Analysis of the age of onset in heritable pulmonary arterial hypertension (HPAH) has led to the hypothesis that genetic anticipation causes younger age of onset and death in subsequent generations. "
4.	Prealbumin (Transthyretin)IBA 06/01/2004 - "Families with a variant transthyretin (TTR V30M)-associated familial amyloidotic polyneuropathy (FAP) exhibit genetic anticipation, with TTR V30M-amyloid depositing at an earlier age in successive generations. " 03/01/2002 - "Familial amyloid polyneuropathy with genetic anticipation associated to a gly47glu transthyretin variant in an Italian kindred."
5.	hydralazine 4-anisaldehyde hydrazoneIBA 11/01/2012 - "Genetic anticipation is likely an artifact of incomplete time of observation of kindreds with HPAH due to BMPR2 mutations." 08/01/2009 - "HPAH is an autosomal dominant disease characterized by reduced penetrance, variable expressivity, female predominance, and genetic anticipation. " 11/01/2012 - "Analysis of the age of onset in heritable pulmonary arterial hypertension (HPAH) has led to the hypothesis that genetic anticipation causes younger age of onset and death in subsequent generations. "
6.	Biological Markers (Surrogate Marker)IBA 02/15/2007 - "Furthermore, telomere shortening could predict genetic anticipation observed in LFS and may serve as the first rational biological marker for clinical monitoring of these patients."
7.	Retinaldehyde (Retinal)IBA 12/01/2009 - "This case is consistent with the previously reported observations of genetic anticipation and variable expressivity in the retinal findings of dyskeratosis congenita."
8.	LithiumIBA 01/01/2007 - "We propose that the introduction of lithium may have increased fertility (broadly defined) of bipolar patients allowing for the expression of genetic anticipation by having a second and third generation of offspring that are affected at earlier ages. "
9.	Immunoglobulin E (IgE)IBA 06/01/2011 - "To our knowledge, this is one of the few reports to describe the occurrence of possible genetic anticipation in IGE which should be further investigated in larger cohorts of patients." 06/01/2011 - "We present two three-generation families with juvenile myoclonic epilepsy (JME) probands and other affected family members with different forms of IGE in whom genetic anticipation was possible, i.e. "
10.	Dopamine (Intropin)FDA LinkGeneric 01/01/1999 - "Various facets of epigenetics are reevaluated through their putative relevance to four theories of schizophrenia: neurodevelopmental, dopamine dysfunction, viral, and genetic anticipation with unstable DNA. "