Genetic Anticipation

The apparent tendency of certain diseases to appear at earlier AGE OF ONSET and with increasing severity in successive generations. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

Also Known As:

Networked: 26 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Schizophrenia (Dementia Praecox)
2.	Mood Disorders (Mood Disorder)
3.	Myotonic Dystrophy (Dystrophia Myotonica)
4.	Fragile X Syndrome (Martin Bell Syndrome)
5.	Intellectual Disability (Idiocy)

Experts

1.	Austin, Eric D: 2 articles (11/2012 - 08/2009)
2.	Loyd, James E: 2 articles (11/2012 - 08/2009)
3.	Phillips, John A: 2 articles (11/2012 - 08/2009)
4.	Tokuda, Takahiko: 2 articles (09/2007 - 06/2004)
5.	Aretz, Stefan: 1 article (01/2019)
6.	Bernstein, Inge: 1 article (01/2019)
7.	Capellá, Gabriel: 1 article (01/2019)
8.	Engel, Christoph: 1 article (01/2019)
9.	Gomez-Garcia, Encarna B: 1 article (01/2019)
10.	Lagerstedt-Robinson, Kristina: 1 article (01/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Genetic Anticipation:

1.	DNA (Deoxyribonucleic Acid)IBA 01/01/2016 - "Single-cell DNA analysis is important in the analysis of genetics of cell clonality, genetic anticipation, and single-cell DNA polymorphisms. " 01/01/2009 - "We could not find any evidence for either of the two currently known molecular mechanisms for genetic anticipation (i.e., expansion of repetitive DNA elements or progressive telomere shortening) in this family. " 02/01/1995 - "All available evidence suggests that this unstable trinucleotide repeat DNA is the biological basis of the clinical phenomenon of genetic anticipation. " 01/01/1995 - "All available evidence suggests that these expanded trinucleotide repeats, or unstable DNA, are the biological basis of the clinical phenomenon of genetic anticipation. " 10/01/1996 - "Search for unstable DNA in schizophrenia families with evidence for genetic anticipation."
2.	Proteins (Proteins, Gene)FDA Link 01/01/1997 - "The topics discussed are: (1) the phenotype of the mutation (including appearance, behavioural changes and mental retardation) and its cytogenetic features, (2) examples and hypotheses of atypical inheritance (genetic anticipation, Sherman paradox and X-inactivation-dependent mechanism giving rise to this disease), (3) molecular studies (the expansion of the CGG repeat as the cause of the instability of the fragile X chromosome), (4) the FMRI gene - its possible role, expression and proteins and (5) diagnosis and tests of the fragile X syndrome."
3.	polyglutamineIBA 01/01/2023 - "A largely autosomal dominant inherited disease, SCA17, is unique in both its heterogeneous clinical presentation and low incidence of genetic anticipation, the phenomenon in which subsequent generations inherit longer polyQ expansions that yield earlier and more severe symptom onset. " 10/01/1996 - "An increased polyglutamine chain size leads to a more severe disease, thus correlating with the genetic anticipation seen in repeat expansion disorders. " 01/01/2016 - "As with most polyglutamine expansion diseases, SCA1 follows the rules of genetic anticipation: the larger the expansion, the earlier and more rapid the symptoms. "
4.	Prealbumin (Transthyretin)IBA 06/01/2004 - "Families with a variant transthyretin (TTR V30M)-associated familial amyloidotic polyneuropathy (FAP) exhibit genetic anticipation, with TTR V30M-amyloid depositing at an earlier age in successive generations. " 03/01/2002 - "Familial amyloid polyneuropathy with genetic anticipation associated to a gly47glu transthyretin variant in an Italian kindred."
5.	hydralazine 4-anisaldehyde hydrazoneIBA 11/01/2012 - "Genetic anticipation is likely an artifact of incomplete time of observation of kindreds with HPAH due to BMPR2 mutations." 08/01/2009 - "HPAH is an autosomal dominant disease characterized by reduced penetrance, variable expressivity, female predominance, and genetic anticipation. " 11/01/2012 - "Analysis of the age of onset in heritable pulmonary arterial hypertension (HPAH) has led to the hypothesis that genetic anticipation causes younger age of onset and death in subsequent generations. "
6.	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/01/2000 - "Substantial evidence exists for a cohort effect (earlier onset and increased prevalence) for both unipolar and bipolar affective disorder in every generation born since World War II. This effect could be related to inherited mechanisms (e.g., bi-Hneal pedigrees or genetic anticipation) or to environmental/experiential effects on gene expression (e.g., stressor effects on the induction of transcription and growth factors, enzymes, hormones and their receptors, and signal transduction molecules) as documented in preclinical models of neonatal maternal separation. "
7.	Biomarkers (Surrogate Marker)IBA 02/15/2007 - "Furthermore, telomere shortening could predict genetic anticipation observed in LFS and may serve as the first rational biological marker for clinical monitoring of these patients."
8.	Retinaldehyde (Retinal)IBA 12/01/2009 - "This case is consistent with the previously reported observations of genetic anticipation and variable expressivity in the retinal findings of dyskeratosis congenita."
9.	LithiumIBA 01/01/2007 - "We propose that the introduction of lithium may have increased fertility (broadly defined) of bipolar patients allowing for the expression of genetic anticipation by having a second and third generation of offspring that are affected at earlier ages. "
10.	Immunoglobulin E (IgE)IBA 06/01/2011 - "To our knowledge, this is one of the few reports to describe the occurrence of possible genetic anticipation in IGE which should be further investigated in larger cohorts of patients." 06/01/2011 - "We present two three-generation families with juvenile myoclonic epilepsy (JME) probands and other affected family members with different forms of IGE in whom genetic anticipation was possible, i.e. "