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5' Untranslated Regions (5' UTR)

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The sequence at the 5' end of the messenger RNA that does not code for product. This sequence contains the ribosome binding site and other transcription and translation regulating sequences.

Also Known As:

5' UTR; 5' Untranslated Region; Leader Sequence, mRNA; 5' UTRs; 5'UTRs; Leader mRNA Sequence; Region, 5' Untranslated; Regions, 5' Untranslated; Sequence, Leader mRNA; Sequence, mRNA Leader; Sequences, Leader mRNA; Sequences, mRNA Leader; UTR, 5'; UTRs, 5'; Untranslated Region, 5'; Untranslated Regions, 5'; mRNA Leader Sequence; mRNA Sequence, Leader; mRNA Sequences, Leader; 5'UTR; Leader Sequences, mRNA; Leader mRNA Sequences; mRNA Leader Sequences

Networked: 1002 relevant articles (6 outcomes, 71 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Song, Linsheng: 18 articles (11/2015 - 10/2006)
2.	Wang, Lingling: 14 articles (11/2015 - 05/2009)
3.	Zhang, Huan: 14 articles (10/2013 - 01/2008)
4.	Qiu, Limei: 14 articles (05/2012 - 08/2007)
5.	Jiang, Shigui: 12 articles (08/2015 - 03/2008)
6.	Tassone, Flora: 12 articles (05/2014 - 12/2002)
7.	Zhao, Jianmin: 12 articles (05/2012 - 08/2007)
8.	Hagerman, Paul J: 11 articles (04/2014 - 10/2003)
9.	Usdin, Karen: 10 articles (06/2014 - 05/2005)
10.	Sherman, Stephanie L: 10 articles (01/2014 - 06/2002)

Related Diseases

1.	Infection 09/01/2005 - "Deletion of the hly 5' UTR, while retaining the hly ribosome binding site, had a moderate effect on LLO production during growth in broth culture, yet resulted in a marked decrease in LLO levels during intracellular infection. " 08/01/2011 - "An improved, sensitive, specific, and rapid one-step reverse transcription loop-mediated isothermal amplification (LAMP) assay targeting the 5' untranslated region (UTR) was developed to detect hepatitis C virus (HCV) infection. " 03/22/2011 - "Deletion mutagenesis studies demonstrated that the 5' UTR SLI was essential for genotypes 1-6 infection. " 08/01/2006 - "In our study we analysed three single nucleotide polymorphisms (SNPs) in the 5' untranslated region (UTR) of the DEFB1 gene, namely -52(G/A) -44(C/G) and -20(G/A), in three groups of northeastern Brazilian children in order to assess their role in HIV-1 infection. " 05/01/2015 - "Genotyping and subtyping of 225 samples with hepatitis C virus (HCV) genotype 1, 2, 3, or 6 infection were done with Versant LiPA 2.0 and Abbott RealTime HCV Genotype (GT) II by using direct sequencing of the NS5B and 5' untranslated regions as the reference standards. "
2.	Chronic Hepatitis C 01/01/2015 - "The HCV 5'UTR was amplified from serum and peripheral blood mononuclear cells (PBMC) samples in 37 HCV/HIV coinfected patients treated for chronic hepatitis C. " 09/01/2011 - "A hepatitis C virus (HCV) strain (HC10-0804) recovered from a 12-year-old Japanese female with chronic hepatitis C segregated into discordant genotypes, 2b and 1b, in the 5'UTR/core and NS5B regions, respectively, thus suggesting an inter-genotypic recombination. " 01/01/2011 - "Comparative performance evaluation of hepatitis C virus genotyping based on the 5' untranslated region versus partial sequencing of the NS5B region of brazilian patients with chronic hepatitis C." 11/01/2002 - "Sequences of 91 isolates from patients with chronic hepatitis C from Yunnan, southwest China, were sequenced and genotypes were defined according to the sequence divergences of the 5'UTR of the virus. " 12/01/1998 - "In patients with chronic hepatitis C, the prevalence of GBV-C/HGV by PCR with the NS3R and 5' UTR primers was 5.1% (4/78) and 17.9% (14/78), respectively, and in patients on hemodialysis, it was 0% (0/81) and 5.9% (5/85), respectively. "
3.	Viremia 02/15/2008 - "HCV was present in the brains of 7 (54%) of 13 patients with viremia, as determined by 5' UTR and E1 (envelope 1) gene analysis. " 03/01/2004 - "HCV viremia, as determined by reverse transcription-PCR (RT-PCR) from the 5' untranslated region, showed continuously positive, occasionally positive, and negative patterns during follow-up. " 08/01/1997 - "Nucleotide sequences of the envelope and 5' untranslated region of the viral genome of these virus strains did not correlate with virulence as measured by mortality in weanling mice, nor viremia levels and duration in chickens." 08/01/1993 - "In all nine of these women, hepatitis C virus viremia was detected on nested polymerase chain reaction (with primers located in the 5' untranslated region). " 10/01/1998 - "Analysis of the secondary structure of the HCV 5'UTR contributes to predicting viremia severity and the efficacy of IFN therapy in patients with chronic hepatitis C."
4.	Seizures (Seizure) 12/01/2009 - "Both the long 5'UTR and long 3'UTR repress translation of GluR2 mRNA; repression by the 3'UTR is relieved after seizures. "
5.	Sarcoma (Soft Tissue Sarcoma) 08/10/2003 - "For comparison, vectors containing the long terminal repeat (LTR) of myeloproliferative sarcoma virus (MPSV) and an improved 5' untranslated region were used (MP71 vectors), with or without the woodchuck hepatitis virus posttranscriptional regulatory element (PRE). "

Related Drugs and Biologics

1.	3' Untranslated Regions (3' UTR)
2.	Messenger RNA (mRNA)
3.	RNA (Ribonucleic Acid)
4.	Interferons
5.	Nucleotides
6.	5' Untranslated Regions (5' UTR)
7.	Complementary DNA (cDNA)
8.	Amino Acids
9.	DNA (Deoxyribonucleic Acid)
10.	Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Transplantation (Transplant Recipients)
3.	Renal Dialysis (Hemodialysis)
4.	Transplants (Transplant)
5.	Therapeutics