Pepsinogen A (Pepsinogen)

This is one of 2 related pepsinogen systems in humans and is also known as pepsinogen. (The other is PEPSINOGEN C.) This includes isozymogens Pg1-Pg5 (pepsinogens 1-5, group I or products of PGA1-PGA5 genes). This is the main pepsinogen found in urine.

Also Known As:

Networked: 1045 relevant articles (28 outcomes, 131 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Haruma, Ken: 14 articles (09/2014 - 02/2002)
2.	Fujishiro, Mitsuhiro: 13 articles (05/2014 - 10/2006)
3.	Ichinose, Masao: 12 articles (03/2014 - 03/2004)
4.	Miki, Kazumasa: 11 articles (01/2011 - 02/2002)
5.	Oka, Masashi: 10 articles (03/2014 - 10/2005)
6.	Tamai, Hideyuki: 10 articles (03/2014 - 03/2004)
7.	Chayama, Kazuaki: 9 articles (10/2015 - 02/2002)
8.	Ito, Masanori: 9 articles (10/2015 - 05/2002)
9.	Yoshihara, Masaharu: 9 articles (10/2015 - 02/2002)
10.	Tanaka, Shinji: 9 articles (10/2015 - 05/2002)

Related Diseases

1.	Duodenal Ulcer (Curling's Ulcer) 12/01/1997 - "The present study examines the polymorphism of pepsinogen by PAGE in 155 duodenal ulcer cases and 92 control subjects. " 01/01/1996 - "To study basal pepsinogen I levels in patients with duodenal ulcer and in subjects with normal endoscopy, depending on Helicobacter pylori status. " 08/01/1990 - "Several studies have shown an influence of cigarette smoking on serum pepsinogen group I (PGI) levels in duodenal ulcer patients and in control subjects. " 09/01/1988 - "The purpose of these controlled studies was to determine the prevalence of acid-pepsinogen hypersecretion in 173 patients with duodenal ulcer disease [88 Americans (75 men, 13 women) and 85 Chinese (66 men, 19 women)]. " 11/01/1986 - "In 1958 the Yale freshman class gave blood samples as part of a study intended to determine the predictive value of plasma pepsinogen (PP) for the subsequent development of duodenal ulcer (DU). "
2.	Gastritis 09/01/2001 - "The study population was randomly selected among 12,252 Finnish men who were screened for atrophic corpus gastritis with serum pepsinogen I-assay (S-PGI). " 10/01/2015 - "Diagnosis of Helicobacter pylori-induced gastritis by serum pepsinogen levels." 06/01/2012 - "The degree of gastritis was assessed in 366 subjects and serum pepsinogen (PG) I/II levels were measured in 108 subjects. " 01/01/2011 - "Pepsinogen I/II ratio allows prediction of the existence of endoscopic gastritis and histological gastritis, or the extent of their development, with high accuracy." 01/01/2011 - "Significant correlations exist between serum pepsinogen levels, endoscopic gastritis, and histological gastritis. "
3.	Infection 09/01/2012 - "Serum pepsinogen and Helicobacter pylori infection--a Japanese population study." 12/15/2007 - "pylori infection with CAG may be strongly underestimated in studies in which CAG is defined by pepsinogen I only." 07/01/2014 - "To investigate the changes in serum pepsinogen (PG) I/II ratio induced by Helicobacter pylori (Hp) infection and assess the value of PG I/II test in evaluating organ damages in hypertensive patients. " 07/01/2014 - "[Changes of serum pepsinogen I/II ratio induced by Helicobacter pylori infection in hypertensive patients]." 01/01/2014 - "pylori infection, serum pepsinogen (PG) (measures for H. "
4.	Weight Gain 11/01/1991 - "Egg counts, herbage larval counts, worm counts of tracer calves, pepsinogen concentrations and weight gains showed a high efficacy of the strategic treatment in group 3 against gastrointestinal nematodes. " 08/01/1997 - "The efficacy of MSRT was assessed by comparison of parasitological data (faecal worm egg counts, herbage larval counts, worm counts from tracer calves and set-stocked trial calves, determination of haematological parameters and pepsinogen levels), weight gains and clinical status of the animals. " 04/01/1987 - "The efficacy of the bolus was assessed by comparison of weight gain performance and parasitological data (fecal worm egg counts, herbage larval counts, worm counts from tracer and principal trial calves, and plasma pepsinogen level determinations). " 09/26/1987 - "The efficacy of the bolus was assessed by comparison of faecal worm egg counts, plasma pepsinogen concentrations, the antibody response to Ostertagia, Cooperia and Dictyocaulus species total plasma protein and albumin concentrations, and weight gains throughout the grazing season and the housing period. " 04/02/2001 - "Egg counts (EPG), larval cultures, pasture larval counts, serum pepsinogen (Pep) and live weight gain (LWG) were recorded monthly. "
5.	Stomach Neoplasms (Stomach Cancer) 08/01/2010 - "This study was performed to compare the efficacy of non-invasive gastric cancer screening through the measurement of pepsinogen (PG) I/II ratio and endoscopic screening using histologic criteria (Meining's risk index for gastric cancer) in Korean patients. " 01/01/2014 - "To identify high-risk groups for gastric cancer in presumptively healthy populations, several studies have investigated the predictive ability of the pepsinogen test, H. " 06/01/2012 - "Optimal cutoff value of the serum pepsinogen level for prediction of gastric cancer incidence: the Hisayama Study." 01/01/2009 - "In conclusion, the present study showed, for the first time to our knowledge, a relation between RUNX3 and pepsinogen I expression in human gastric cancers. " 06/01/2007 - "The study results suggest that gastric cancer screening using the pepsinogen method may reduce mortality from gastric cancer."

Related Drugs and Biologics

1.	Gastrins
2.	Pepsinogen C
3.	Pepsinogen A (Pepsinogen)
4.	Immunoglobulin G (IgG)
5.	Antibodies
6.	gastrin 17 (G 17)
7.	Prostaglandins A (PGA)
8.	Proton Pumps (Proton Pump)
9.	Morantel
10.	Iron

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Gastrectomy
3.	Vagotomy
4.	Gastroenterostomy
5.	Proximal Gastric Vagotomy