Pinacidil (Pindac)

A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)

Also Known As:

Networked: 291 relevant articles (22 outcomes, 40 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Eckardt, Lars: 4 articles (10/2018 - 06/2007)
2.	Dechering, Dirk G: 3 articles (10/2018 - 10/2016)
3.	Ellermann, Christian: 3 articles (10/2018 - 10/2016)
4.	Frommeyer, Gerrit: 3 articles (10/2018 - 10/2016)
5.	Kochhäuser, Simon: 3 articles (10/2018 - 10/2016)
6.	Yu, Tian: 3 articles (06/2016 - 12/2011)
7.	Cao, Su: 3 articles (07/2015 - 05/2015)
8.	Shen, Shiren: 3 articles (07/2015 - 05/2015)
9.	Franova, S: 3 articles (01/2015 - 11/2007)
10.	Sutovska, M: 3 articles (01/2015 - 11/2007)

Related Diseases

1.	Ischemia 08/01/2000 - "Pinacidil presents a safe and effective alternative to IPC for preserving the heart during regional ischemia. " 07/01/2005 - "Effects of pinacidil on reentrant arrhythmias generated during acute regional ischemia: a simulation study." 05/01/2005 - "This study determines the effects of pinacidil pretreatment on arrhythmias and the changes in cellular electrophysiological parameters in segments of guinea pig right ventricular free walls exposed to simulated ischemia and reperfusion. " 06/05/2016 - "Langendorff rat hearts were randomly assigned to one of the following groups (n=8 each): Control group, I/R group (40min ischemia and 60min reperfusion), IPO group (6 successive cycles of 10s reperfusion per 10s occlusion before fully reperfusion), PPO group (perfused with 50μM pinacidil for 5min before reperfusion). " 09/08/2015 - "Unlike DZX, pinacidil promoted ischemia-mediated arrhythmias in both control and T2DM hearts. "
2.	Hypertension (High Blood Pressure) 01/01/1988 - "Based upon these data, low (12.5-25mg bid) doses of pinacidil are effective and safe as monotherapy for hypertension. " 01/01/1985 - "In an open study, thirteen chronic dialysis patients with nonvolume dependent uncontrolled hypertension were treated with pinacidil for a mean period of 43 weeks. " 03/01/2006 - "It was concluded that a single patch application of pinacidil TDDS (B-4) can effectively control hypertension in rats for 2 days. " 04/01/1991 - "The results show that pinacidil is a potent arterial dilator but has little effect on the venomotor tone in patients with hypertension." 03/01/1990 - "Twenty-two patients with mild to moderate hypertension received 20 mg of pinacidil daily for six weeks, followed by 40 mg daily for another six weeks. "
3.	Reperfusion Injury 06/01/2002 - "We investigated whether a KATP opener, pinacidil, can attenuate ischemia-reperfusion injury using an ex vivo rat lung model. " 06/05/2016 - "Pinacidil-postconditioning is equivalent to ischemic postconditioning in defeating cardiac ischemia-reperfusion injury in rat." 11/01/2001 - "To investigate the effectiveness of pinacidil, an opener of ATP-sensitive K+ channels, in protecting the myocardium of immature rabbit hearts from ischemic reperfusion injury. " 04/01/1990 - "Thus, both cromakalim and pinacidil reduce ischemic/reperfusion injury, though the timing of treatment may be important." 08/01/2003 - "Potassium channel openers with pinacidil can provide pulmonary protection against warm ischemia reperfusion injury."
4.	Hypoxia (Hypoxemia) 10/08/2014 - "The aim of this study was to evaluate the cardioprotective effect of pinacidil postconditioning on rat hearts with transient hypoxia and reperfusion. " 10/08/2014 - "Effect of pinacidil on rat ventricular myocytes during transient hypoxia and reperfusion." 10/01/2011 - "Human cerebral arteries also expressed SUR2B, developed myogenic tone, and dilated in response to hypoxia and pinacidil. " 11/01/2003 - "We suggest that adaptation by intermittent hypoxia and application of a KATP opener pinacidil possess significant protective effect on mitochondrial energy support under stress condition. " 04/20/2001 - "This effect of pinacidil, in cells expressing Kir6.2/SUR2A, was observed regardless of whether pinacidil was added only during hypoxia or reoxygenation. "
5.	Ventricular Fibrillation 10/01/2018 - "Under baseline conditions, ventricular fibrillation (VF) was inducible in 5 of 14 hearts (10 episodes) and in 5 of 14 pinacidil-treated hearts (21 episodes, P = ns). " 06/01/2007 - "During programmed ventricular stimulation with up to two extrastimuli, pinacidil significantly increased the inducibility of ventricular fibrillation (1 heart under baseline conditions, 29 hearts during pinacidil administration; P = 0.0001). " 05/01/2003 - "Ventricular fibrillation (VF) developed in 11 of 12 pinacidil-treated hearts whereas none of the SNC-80-treated (zero of six) hearts developed VF (P < 0.001 compared with pinacidil pretreatment) and zero of four BMS-191095-pretreated hearts developed VF. " 07/01/1997 - "CONCLUSIONS: Pinacidil does not alter defibrillation threshold, but it reduces effective refractory period, action potential duration, and ventricular fibrillation cycle length and does not increase electrical heterogeneity. " 07/01/1997 - "However, pinacidil did not change the basal level of dispersion in effective refractory period, action potential duration, and ventricular fibrillation cycle length during paced rhythm or ventricular fibrillation. "

Related Drugs and Biologics

1.	KATP Channels
2.	Adenosine Triphosphate (ATP)
3.	Potassium Channels (Potassium Channel)
4.	Solutions
5.	Glyburide (Glibenclamide)
6.	Cromakalim (Levcromakalim)
7.	Vasodilator Agents (Vasodilators)
8.	Potassium
9.	Acetazolamide (Diamox)
10.	Calcium

Related Therapies and Procedures

1.	Induced Heart Arrest (Cardioplegia)
2.	Ligation
3.	Warm Ischemia
4.	Therapeutics
5.	Intravenous Administration