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Nicorandil (SG 75)

A derivative of the NIACINAMIDE that is structurally combined with an organic nitrate. It is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase.

Also Known As:

SG 75; SG75; 2-Nicotinamidethyl Nitrate; Adancor; Aventis Brand of Nicorandil; Aventis Pharma Brand of Nicorandil; Dancor; Ikorel; Merck Brand of Nicorandil; Merck Lipha Santé Brand of Nicorandil; Rhône-Poulenc Rorer Brand of Nicorandil; SG-75; 2 Nicotinamidethyl Nitrate; 2 Nicotinamidoethyl Nitrate; Nicorandil Aventis Brand; Nicorandil Merck Brand; Nitrate, 2-Nicotinamidethyl; Nitrate, 2-Nicotinamidoethyl; Rhône Poulenc Rorer Brand of Nicorandil; 2-Nicotinamidoethyl Nitrate; 3-Pyridinecarboxamide, N-(2-(Nitroxy)ethyl)-

Networked: 606 relevant articles (97 outcomes, 125 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ishizuka, Nobuhiko: 9 articles (03/2015 - 11/2002)
2.	Lee, Tsung-Ming: 7 articles (03/2009 - 01/2002)
3.	Toyama, Takuji: 6 articles (04/2015 - 10/2002)
4.	Kobayashi, Hiroyuki: 6 articles (04/2015 - 12/2006)
5.	Chang, Nen-Chung: 6 articles (03/2009 - 10/2004)
6.	Murohara, Toyoaki: 6 articles (05/2007 - 07/2003)
7.	Amano, Tetsuya: 5 articles (07/2015 - 08/2005)
8.	Nishimura, Masato: 5 articles (04/2015 - 01/2009)
9.	Yamazaki, Satoru: 5 articles (04/2015 - 01/2009)
10.	Hashimoto, Tetsuya: 5 articles (04/2015 - 01/2009)

Related Diseases

1.	Ischemia 01/01/1992 - "In isolated, perfused rat hearts subjected to 20 min of low-flow (1.0 ml/min) global ischemia followed by 30 min of reperfusion, nicorandil (7 microM) resulted in a significant improvement in the recovery of isovolumic left ventricular minute work during reperfusion compared with untreated hearts. " 01/01/1991 - "[Protective effects of nicorandil on myocardial mitochondria function during ischemia and reperfusion]." 01/07/2011 - "Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria." 11/01/1982 - "Prophylaxis of ischemia and improved hemodynamics under the influence of SG-75 were probably due to a decrease in preload (left ventricular enddiastolic pressure -41%) and afterload (stroke volume ratio -29%). " 01/28/2008 - "In this study, we determined the signal transduction activated in heart after 3 or 8 cycles of preconditioning and prolonged ischemia in rabbits treated with placebo or nicorandil. "
2.	Myocardial Ischemia (Ischemic Heart Diseases) 04/01/1997 - "In each case, intraoperative myocardial ischemia was treated successfully with nicorandil. " 04/01/1997 - "We report five patients who developed intraoperative myocardial ischemia but were treated successfully with nicorandil. " 04/01/1994 - "Evaluation of the efficacy of nicorandil in patients with ischemic heart disease by exercise Tl-201 myocardial SPECT." 11/01/1982 - "[Efficacy of nicorandil (SG-75), a substance with nitro-properties and long-term effects in coronary patients: improvement of LV-function and wall motility without pacing-induced myocardial ischemia]." 01/01/2000 - "They were divided into two groups for a randomized double blind trial: nicorandil was administered in one group (group N) and placebo in another (group C), and we investigated the effect of prophylactic nicorandil infusion to reduce intraoperative myocardial ischemia. "
3.	Angina Pectoris 10/01/2000 - "Nicorandil significantly improved the results of exercise tolerance tests versus baseline in patients with stable effort angina pectoris in early noncomparative trials. " 10/01/1986 - "Comparative efficacy of high-dose versus low-dose nicorandil therapy for chronic stable angina pectoris." 06/01/2007 - "Double-blind, multicenter, active-controlled, randomized clinical trial to assess the safety and efficacy of orally administered nicorandil in patients with stable angina pectoris in China." 01/22/2014 - "The aim of the study was evaluation of the impact of the administration of intravenous nicorandil on measuring the index of microcirculatory resistance (IMR) in PCI to patients with stable angina pectoris (SAP). " 01/22/2014 - "Nicorandil prevents microvascular dysfunction resulting from PCI in patients with stable angina pectoris: a randomised study."
4.	Heart Failure 06/20/1989 - "Thus, the results of this first study of nicorandil in congestive heart failure demonstrated the unloading action of this compound on the failing heart, leading to an improvement in cardiac function; further investigation of nicorandil in this therapeutic area is needed." 01/01/1999 - "Nicorandil may prove to be useful in the treatment of acute ischemic heart failure." 10/01/2005 - "Treatment of DS rats with nicorandil improved cardiac function and attenuated the development of heart failure. " 10/01/2009 - "This study was conducted to evaluate the acute efficacy and safety of intravenous administration of nicorandil in patients with acute heart failure syndromes (AHFS), under noninvasive hemodynamic assessment with transthoracic Doppler echocardiography. " 09/01/2008 - "The aims of the study were 1) to evaluate the pharmacokinetics of nicorandil in healthy subjects and acute heart failure (AHF) patients and 2) to evaluate the exposure-response relationship with pulmonary arterial wedge pressure (PAWP) in AHF patients and to predict an appropriate dosing regimen for nicorandil. "
5.	Spasm (Spasms) 10/01/2014 - "This suggested that microvascular spasm and the epicardial spasm were not relieved by ISDN but by nicorandil. " 10/01/2007 - "Intracoronary administration of nicorandil only transiently relieved coronary artery spasm. " 05/01/2000 - "Refractory coronary spasm relieved by intracoronary administration of nicorandil." 09/03/2007 - "Nicorandil with vasodilator effects by a dual mechanism was effective as the cocktail in preventing radial artery spasm during transradial coronary angiography." 09/03/2007 - "There was no statistically significant difference between the two groups in radial artery spasm (50.7% vs. 52.0% in nicorandil and a cocktail, respectively) after catheterization. "

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