Troponin T (Troponin T1)

A TROPONIN complex subunit that binds to TROPOMYOSIN. There are three troponin T subtypes: troponin T1, T2 and T3. Troponin T2 is cardiac-specific whereas troponin T2 and T3 are skeletal subtypes. Troponin T2 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin T2 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.

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Networked: 4001 relevant articles (102 outcomes, 539 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Giannitsis, Evangelos: 77 articles (03/2022 - 01/2002)
2.	Katus, Hugo A: 75 articles (06/2022 - 01/2002)
3.	Mueller, Christian: 51 articles (05/2022 - 12/2004)
4.	Lindahl, Bertil: 51 articles (02/2022 - 05/2002)
5.	Ballantyne, Christie M: 49 articles (03/2022 - 04/2011)
6.	Jaffe, Allan S: 40 articles (12/2022 - 06/2004)
7.	Omland, Torbjørn: 36 articles (10/2022 - 07/2009)
8.	Januzzi, James L: 35 articles (10/2022 - 12/2002)
9.	Twerenbold, Raphael: 35 articles (05/2022 - 05/2011)
10.	Selvin, Elizabeth: 32 articles (11/2021 - 01/2012)

Related Diseases

1.	Myocardial Infarction 03/01/2012 - "High-sensitivity cardiac troponin T (cTnT) assays detect small clinically important myocardial infarctions (MI) but also yield higher rates of false-positive results owing to increased concentrations sometimes present in patients without MI. " 11/26/2019 - "Background High-sensitivity cardiac troponin T/I (hs-cTnT/I) assays have improved analytical sensitivity for the detection of myocardial infarction (MI). " 01/01/2017 - "Redefining the Gold Standard of Myocardial Infarction Using Troponin T." 08/18/2001 - "Performance of the diagnostic test against a gold standard consisting of either a 48 hour measurement of troponin T concentration or screening for myocardial infarction according to the World Health Organization's criteria. " 01/01/1999 - "Can troponin T replace CK MBmass as "gold standard" for acute myocardial infarction ("AMI")?"
2.	Infarction (Infarctions) 01/01/2020 - "We showed that IL-35 conferred protection from MIRI as demonstrated by reduced infarct size and cardiac troponin T, improved cardiac function and decreased cardiomyocyte apoptosis in a mouse model. " 06/01/2014 - "Compared with vehicle treatment, mice treated with IL-37 showed an obvious amelioration of the I/R injury, as demonstrated by reduced infarct size, decreased cardiac troponin T level and improved cardiac function. " 01/01/2014 - "CoPP-treated diabetic animals improved cardiac function (43±2% p<0.01), reduced CK, Troponin T levels and infarct size compared to non-treated diabetic mice (P<0.01, P<0.001, P<0.01 respectively). " 11/11/2003 - "An intracoronary application of a selective deltaPKC inhibitor to the heart at the time of reperfusion reduced infarct size, improved cardiac function, inhibited troponin T release, and reduced apoptosis. " 01/01/2016 - "Treatment with m21G6 significantly reduced infarct size and troponin-T release, and led to marked preservation of cardiac function in our study. "
3.	Acute Coronary Syndrome 05/01/2001 - "The diagnostic efficacy of the rapid troponin T test was remarkable in patients with the non-ST elevation type of acute coronary syndrome. " 01/01/2018 - "Efficacy of High-Sensitivity Troponin T in Identifying Very-Low-Risk Patients With Possible Acute Coronary Syndrome." 07/01/2011 - "Improved diagnostic and prognostic performance of a new high-sensitive troponin T assay in patients with acute coronary syndrome." 04/01/2011 - "A third troponin T blood sample is not cost-effective in patients with suspected non-ST segment elevation acute coronary syndrome." 06/30/1999 - "Analysis of cardiac troponin T and I have been shown to be effective in detecting minor myocardial injury in cardiac patients who present with acute coronary syndromes (ACS). "
4.	Chest Pain (Chest Pains) 01/01/2019 - "The objective of this study was to quantify test characteristics of sex-specific cut-offs of a single, high-sensitivity cardiac troponin T (hs-cTnT) assay for 7-day MI in patients with chest pain. " 01/15/2016 - "Recent studies have indicated that it may be safe to discharge chest pain patients with an initial high-sensitivity cardiac troponin T (hs-cTnT) level of <5 ng/L from the emergency department (ED) without further evaluation. " 01/04/2016 - "Previous studies indicate that the introduction of high-sensitivity troponin T (HsTnT) as a diagnostic tool for chest pain patients in the emergency department (ED) creates a high rate of false-positive tests. " 08/01/2013 - "The goal of our study is to compare negative predictive value of the algorithm in the chest pain unit using the fourth-generation troponin T assay (4GTT) vs high-sensitivity troponin T assay (HSTT). " 01/01/2013 - "The goal of this study was to determine the ability of a single, resting high-sensitivity troponin T (hsTnT) measurement to predict abnormal myocardial perfusion imaging (MPI) in patients presenting with acute chest pain to the emergency department (ED). "
5.	Heart Failure 01/01/2023 - "This study aimed to evaluate the cumulative high-sensitivity cardiac troponin T (hs-cTNT) from admission to 12 months after discharge and its association with mortality after 12 months among patients with acute heart failure (HF). " 01/01/2023 - "This study aimed to show whether high-sensitivity troponin T is a predictor of all-cause mortality and the cut-off value for high-sensitivity troponin T in patients with nonischemic heart failure with reduced ejection fraction. " 01/01/2023 - "High-sensitivity troponin T has frequently been investigated in ischemic heart failure studies. " 01/01/2021 - "High-sensitivity cardiac troponin T and the risk of heart failure in postmenopausal women of the ARIC Study." 04/01/2019 - "The aim of this work was to study the association of high-sensitivity troponin T (hsTnT) with incident heart failure (HF), and implications for its use in prediction models. "

Related Drugs and Biologics

1.	Brain Natriuretic Peptide (Natrecor)
2.	Trinitrotoluene (TNT)
3.	Biomarkers (Surrogate Marker)
4.	Troponin I
5.	C-Reactive Protein
6.	Enzymes
7.	pro-brain natriuretic peptide (1-76)
8.	MB Form Creatine Kinase
9.	Proteins (Proteins, Gene)
10.	Creatine Kinase (Creatine Phosphokinase)

Related Therapies and Procedures

1.	Percutaneous Coronary Intervention
2.	Therapeutics
3.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
4.	Vascular Surgical Procedures
5.	Continuous Positive Airway Pressure