Acquired Hyperostosis Syndrome (SAPHO Syndrome)

Syndrome consisting of synovitis, acne, palmoplantar pustulosis, hyperostosis, and osteitis (SAPHO). The most common site of the disease is the upper anterior chest wall, characterized by predominantly osteosclerotic lesions, hyperostosis, and arthritis of the adjacent joints. The association of sterile inflammatory bone lesions and neutrophilic skin eruptions is indicative of this syndrome.

Also Known As:

Networked: 102 relevant articles (18 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Osteitis
2.	Acne Vulgaris
3.	Hyperostosis
4.	Synovitis
5.	Osteomyelitis

Experts

1.	Trotta, F: 3 articles (01/2009 - 06/2006)
2.	Amital, H: 3 articles (11/2008 - 05/2004)
3.	Ferguson, Polly J: 2 articles (07/2015 - 09/2013)
4.	Przepiera-Będzak, Hanna: 2 articles (01/2015 - 01/2013)
5.	Fischer, Katarzyna: 2 articles (01/2015 - 01/2013)
6.	Brzosko, Marek: 2 articles (01/2015 - 01/2013)
7.	Wendling, Daniel: 2 articles (10/2014 - 06/2012)
8.	Prati, Clément: 2 articles (10/2014 - 06/2012)
9.	Trotta, Francesco: 2 articles (07/2014 - 07/2010)
10.	Colina, Matteo: 2 articles (07/2014 - 07/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acquired Hyperostosis Syndrome:

1.	pamidronate (APD)FDA LinkGeneric 05/01/2004 - "Pamidronate seems to be a very effective mode of therapy for patients with the SAPHO syndrome, by promoting remission in all components of the disorder, such as bone, joint and skin involvement, and ceases the bouts that characterize this disorder." 01/01/2009 - "Sustained remission of SAPHO syndrome with pamidronate: a follow-up of fourteen cases and a review of the literature." 01/01/2009 - "Pamidronate appears to be an effective treatment in the osteo-articular manifestations of SAPHO syndrome. " 02/01/2002 - "Pamidronate: a novel treatment for the SAPHO syndrome?" 01/01/2009 - "To evaluate the efficacy of intravenous (i.v.) pamidronate in patients with SAPHO syndrome refractory to first line treatments and to review the available literature on pamidronate for this indication. "
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/01/2012 - "Several studies suggested entercept, a novel biological agent against tumor necrosis factor-alpha, is effective in treating SAPHO syndrome. " 05/01/2003 - "Persistent efficacy of tumor necrosis factor alpha blockage therapy in SAPHO syndrome: comment on the article by Wagner et al." 08/01/2010 - "We describe 6 cases of patients with SAPHO syndrome treated with anti-TNF-alpha between 2004 and 2008. " 08/01/2010 - "Tumor necrosis factor-alpha blockers in SAPHO syndrome." 04/01/2008 - "A literature search of SAPHO syndrome cases treated with TNF-alpha blocking therapy with special emphasis on osteoarticular and skin responses was performed. "
3.	TNFR-Fc fusion protein (etanercept)FDA Link 09/01/2010 - "SAPHO syndrome with unusual cutaneous manifestations treated successfully with etanercept." 06/01/2015 - "Etanercept in the treatment of SAPHO syndrome." 04/01/2011 - "[Successful therapy of sacroiliitis in SAPHO syndrome by etanercept]." 06/01/2015 - "SAPHO syndrome associated with acne conglobata successfully treated with etanercept."
4.	Chronic recurrent multifocal osteomyelitisIBA 04/01/2008 - "Eighteen cases were identified: 17 SAPHO syndrome and 1 chronic recurrent multifocal osteomyelitis, a juvenile variant of SAPHO syndrome. " 06/01/2003 - "Chronic recurrent multifocal osteomyelitis as a presentation of SAPHO syndrome." 08/01/2000 - "In adults, chronic recurrent multifocal osteomyelitis is now a classical manifestation of SAPHO syndrome. " 07/01/1993 - "Chronic recurrent multifocal osteomyelitis, which is seen mostly in children, may be a presentation of SAPHO syndrome. " 09/01/2002 - "The aim of this work is the revision of the Chronic Infectious Multifocal Osteomyelitis and the Chronic Recurrent Multifocal Osteomyelitis into SAPHO syndrome that both were the possibilities diagnoses."
5.	infliximab (Remicade)FDA Link 01/01/2009 - "Response to infliximab in SAPHO syndrome." 06/01/2007 - "However, in the present case, the syndrome developed three months after starting infliximab (Remicade) therapy, which is generally used to treat the SAPHO syndrome. " 06/01/2006 - "Infliximab seems to be a very effective therapy for osteoarticular complaints of SAPHO syndrome. " 06/01/2006 - "Between 2002 and 2005, four cases of SAPHO syndrome (two females and two males; mean age 49.7 yr) responding poorly to conventional drugs were treated with infliximab. " 06/01/2006 - "We report our experience with infliximab in four cases of SAPHO syndrome refractory to conventional therapies. "
6.	Anti-Bacterial Agents (Antibiotics)IBA 07/01/2014 - "Antibiotics may be useful in the treatment of SAPHO syndrome." 12/01/2012 - "The early recognition, diagnosis, and prompt treatment of SAPHO syndrome can prevent the unnecessary use of long-term antibiotics or invasive procedures, while rapidly alleviating pain in a majority of affected patients." 01/01/2009 - "Prompt SAPHO syndrome recognition, followed by appropriate therapy with antibiotics and NSAIDs can produce rapid symptom resolution, while avoiding unnecessary procedures and longterm antibiotic therapy." 01/01/2010 - "Specific features of SIBJ in children at the present time are: 1) pathomorphosis of hematogenic osteomyelitis; 2) the appearance of previously not noted new forms of SIBJ--fetal osteomyelitis and arthritis, chronic recurring multifocal osteomyelitis, syndrome SAPHO and increasing frequency of previously rare BCG-osteomyelitis, exogenous osteomyelitis, sacroiliitis and inervertebral disciitis; 3) widening the spectrum of SIBJ pathogens with an increasing significance of involutionary forms of bacteria, elevation of their resistence to antibiotics and antiseptics, increase of the factors promoting the development of immunodeficient states in childhood." 12/01/2009 - "Treatment of SAPHO syndrome should include antibiotics and NSAIDs; corticosteroids may be helpful. "
7.	Technetium Tc 99m MedronateIBA 07/01/2001 - "Tc-99m MDP bone scanning may be helpful in diagnosing arthritis as associated with the SAPHO syndrome." 01/01/2010 - "SAPHO syndrome without dermatologic manifestations: multifocal uptake mismatch on 99mTc-MDP and 18FDG-FDG-PET/CT imaging."
8.	Alendronate (Alendronate Sodium)FDA LinkGeneric 06/01/2008 - "Efficacy of alendronate in the treatment of the SAPHO syndrome."
9.	Prednisolone (Predate)FDA LinkGeneric 03/01/2012 - "A case of SAPHO syndrome with diffuse sclerosing osteomyelitis of the mandible treated successfully with prednisolone and bisphosphonate."
10.	Indomethacin (Indometacin)FDA LinkGeneric 12/27/1996 - "The SAPHO syndrome improved considerably during the course of this pregnancy and treatment with indomethacin ceased during gestation."

Therapies and Procedures

1.	Immunotherapy 01/01/2010 - "The authors suggest that SAPHO syndrome might be caused by an association with BCG immunotherapy." 01/01/2010 - "The authors describe a case of SAPHO syndrome with bacillus Calmette-Guérin (BCG) immunotherapy for bladder cancer. " 01/01/2010 - "SAPHO syndrome with bacillus Calmette-Guerin (BCG) immunotherapy for bladder cancer."
2.	Decompression 01/01/2004 - "The authors report the poor evolution of the disease in a patient affected with Sapho syndrome who came to our observation after being submitted to medullary decompression of the femoral diaphysis because of the presence of metaphyseal hyperostosis of the left femur."
3.	Biological Therapy 01/01/2012 - "[The use of biological therapy in the SAPHO syndrome]."