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N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B)

An arylsulfatase that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. A deficiency of this enzyme is responsible for the inherited lysosomal disease, Maroteaux-Lamy syndrome (MUCOPOLYSACCHARIDOSIS VI). EC 3.1.6.12.
Also Known As:
Arylsulfatase B; Arylsulfatase B1; Arylsulfatase B2; N-Acetylgalactosamine 4-Sulfatase; N-Acetylgalactosamine-4-sulfate Sulfatase; N-Acetylgalactosamine-4-sulphate Sulphatase; 4-Sulfatase, N-Acetylgalactosamine; B1, Arylsulfatase; B2, Arylsulfatase; N Acetylgalactosamine 4 Sulfatase; N Acetylgalactosamine 4 sulfate Sulfatase; N Acetylgalactosamine 4 sulphate Sulphatase; Sulfatase, N-Acetylgalactosamine-4-sulfate; Sulphatase, N-Acetylgalactosamine-4-sulphate; N-Acetyl-D-Galactosamine-4-sulfate 4-sulfohydrolase
Networked: 227 relevant articles (6 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Hopwood, John J: 17 articles (12/2018 - 04/2002)
2. Giugliani, Roberto: 14 articles (01/2022 - 01/2003)
3. Harmatz, Paul: 14 articles (01/2019 - 05/2004)
4. Bhattacharyya, Sumit: 13 articles (01/2022 - 05/2007)
5. Tobacman, Joanne K: 13 articles (01/2022 - 06/2003)
6. Scarpa, Maurizio: 9 articles (01/2019 - 04/2006)
7. Feferman, Leo: 8 articles (01/2019 - 06/2014)
8. Ketteridge, David: 7 articles (08/2014 - 06/2005)
9. Guffon, Nathalie: 6 articles (08/2014 - 04/2006)
10. Swiedler, Stuart J: 6 articles (02/2010 - 06/2005)

Related Diseases

1. Mucopolysaccharidosis VI (Syndrome, Maroteaux-Lamy)
2. Neoplasms (Cancer)
3. Vitamin A Deficiency
4. Papilledema
5. Lysosomal Storage Diseases (Lysosomal Storage Disease)

Related Drugs and Biologics

1. N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B)
2. Neutralizing Antibodies
3. galsulfase
4. Graphite
5. Enzymes
6. Cerebroside-Sulfatase (Arylsulfatase A)
7. Iduronidase (alpha-L-Iduronidase)
8. Eosinophil Cationic Protein
9. Arylsulfatases
10. Tamoxifen

Related Therapies and Procedures

1. Enzyme Replacement Therapy
2. Therapeutics
3. Drug Therapy (Chemotherapy)