Cocaine-Related Disorders (Cocaine Addiction)

10/01/1997 - "Rates of complete abstinence during the 6-month study period were higher in STND than RP, whereas RP was more effective in limiting the extent of cocaine use in those who used during Months 1-3. Matching analyses indicated patients who failed to achieve remission from cocaine dependence during IOP and those with a commitment to absolute abstinence did better in RP than in STND, whereas patients with other abstinence goals did better in STND than RP. "
08/01/2014 - "Thus, disruption of cocaine reward memories by interference with reconsolidation may be therapeutically beneficial in the treatment of cocaine addiction. "
06/01/2005 - "Self reported cocaine use, cocaine craving, and global impression scores showed moderate improvement in both groups, with a significantly greater reduction in cocaine craving (p < 0.05) and self-rated severity of cocaine dependence (p < 0.05) in the placebo group. "
10/01/2004 - "Expanding research on reward-related brain circuitry, which is acutely activated and chronically dysregulated by cocaine, has helped reveal the neurobiological features of cocaine dependence and is guiding pharmacologic strategies that have significant potential to improve clinical outcome. "
08/01/2003 - "While the improvements were not significant between groups, within-group analysis revealed that the treatment group reduced self-reported cocaine use (P = 0.02), reduced criminal activity (P = 0.04), reduced cravings (P < 0.01) and reduced severity of cocaine dependence (P < 0.01) with no within-group improvements found in the placebo group. "

12/01/2013 - "Disulfiram (DSF), used for the treatment of alcohol use disorders (AUDs) for over six decades, most recently has shown promise for treating cocaine dependence. "
02/01/2013 - "A variant in the gene encoding DβH leads to reduced DβH activity, and as such, disulfiram might not be an effective treatment of cocaine dependence for individuals with this variant. "
04/01/2004 - "Converging evidence suggests that disulfiram is a promising treatment for cocaine dependence. "
01/01/2012 - "This study indicates that a patient's MTHFR genotype may be used to identify individuals who might show improved response to disulfiram treatment for cocaine dependence. "
12/01/2011 - "Previous studies demonstrated efficacy of disulfiram in the treatment of cocaine dependence among patients with comorbid alcohol use disorder or opioid dependence. "

03/01/2009 - "Comparable efficacy of contingency management for cocaine dependence among African American, Hispanic, and White methadone maintenance clients."
01/01/2010 - "There were no significant differences between interventions, and in trials where participants had primary cocaine dependence or had additional diagnosis of opioid dependence and/or were in methadone maintenance treatment. "
05/01/2009 - "Although steady-state methadone (SSM) treatment is mainly used for opioid addiction, some clinical studies indicate that it also reduces cocaine abuse in opioid-dependent individuals. "
08/01/2006 - "Similarly, the impact of cocaine abuse on psychiatric and social function in subjects already affected by opioid addiction is still poorly understood and further studies are necessary to investigate this specific area that could profoundly affect methadone maintenance treatment. "
01/01/2003 - "There were no significant differences between interventions, and in trials where participants had primary cocaine dependence or had additional diagnosis of opioid dependence and/or were in methadone maintenance treatment. "

06/14/2006 - "Because craving is a key contributor to relapse, strategies aimed at inhibiting dopamine increases from conditioned responses are likely to be therapeutically beneficial in cocaine addiction."
02/01/1995 - "Agents that interact with specific subcomponents of the dopamine system or its connections offer promise for the development of successful agents to treat cocaine abuse and craving in humans."
06/01/2014 - "Evidence from animal models and postmortem human studies points to the importance of the dopamine D₃ receptor (D₃R) in cocaine dependence (CD). "
09/01/2012 - "Brain imaging and behavioral studies suggest an inverse relationship between dopamine (DA) D2/D3 receptors and vulnerability to cocaine abuse, although most research has used males. "
12/01/2011 - "Imaging of dopamine D2/3 agonist binding in cocaine dependence: a [11C]NPA positron emission tomography study."

12/01/2003 - "In addition, clinical experience shows that heroin and cocaine addiction can best be conceptualised and treated as a chronic, relapsing disorder with the following treatment goals: crisis intervention, cure or recovery (detoxification, relapse prevention) and care or partial remission (stabilization and harm reduction). "
01/01/2009 - "To determine the efficacy of Opiate Maintenance Therapy (OMT) and adjunctive interventions for dual heroin and cocaine dependence by means of a meta-analysis. "
11/01/2015 - "The study supports the involvement of genetic variation in signal transduction pathways in heroin and cocaine addiction and provides preliminary evidence suggesting several new risk or protective loci that may be relevant for diagnosis and treatment success."
11/01/2015 - "This study was designed to assess whether 185 variants in 32 genes central to synaptic plasticity and signal transduction contribute to vulnerability to develop heroin and/or cocaine addiction. "
07/01/2014 - "This hypothesis-driven study was designed to determine if specific SNPs in genes related to stress response are associated with heroin and/or cocaine addiction in African Americans. "

09/06/2004 - "Topiramate may be effective for the treatment of cocaine dependence."
09/06/2004 - "The efficacy of topiramate for cocaine dependence was tested in a 13-week, double-blind, placebo-controlled pilot trial (n = 40). "
12/01/2013 - "To determine the efficacy of topiramate vs placebo as a treatment for cocaine dependence. "
09/01/2014 - "In cocaine-related disorder, one single-center trial showed a reduction of days of consumption and two single-center trials have found a trend in favour of topiramate. "
05/01/2014 - "Given the equivocal results of previous studies and the negative findings in our study, the potential of topiramate in the treatment of cocaine dependence seems limited."

05/01/2002 - "Sustained release dextroamphetamine (15-30 mg but not 30-60 mg) improved retention in patients with cocaine dependence."
04/01/2010 - "The results of preclinical laboratory experiments and clinical trials indicate that agonist replacements such as d-amphetamine may be a viable option for managing cocaine dependence. "
10/01/2009 - "Recent studies have investigated D-amphetamine as a potential agonist medication for cocaine dependence. "
01/01/2009 - "The results of preclinical laboratory studies and clinical trials indicate that agonist replacements like D-amphetamine may be a viable option for managing cocaine dependence. "
08/01/2003 - "Pilot randomized double blind placebo-controlled study of dexamphetamine for cocaine dependence."

01/01/2009 - "Olanzapine in cocaine dependence: a double-blind, placebo-controlled trial."
06/05/2003 - "The results of this trial do not support the usefulness of olanzapine for the treatment of cocaine dependence. "
06/05/2003 - "A pilot trial of olanzapine for the treatment of cocaine dependence."
01/01/2009 - "We conclude that olanzapine appears ineffective for cocaine dependence."
03/01/2006 - "The neuropharmacological profile of the atypical antipsychotic, olanzapine, is consistent with a potentially useful medication for cocaine abuse. "

06/01/1983 - "An extreme case of cocaine dependence and marked improvement with methylphenidate treatment."
06/01/1998 - "This open trial was carried out to assess the efficacy of sustained-release methylphenidate for the treatment of cocaine abuse among individuals with ADHD. "
06/01/1998 - "These preliminary data suggest that under close supervision, the combined intervention of sustained-release methylphenidate and relapse prevention therapy may be effective in treating individuals with both adult ADHD and cocaine dependence."
04/01/2015 - "The current study determined if extending treatment beyond adolescence would ameliorate long-term consequences of adolescent methylphenidate treatment on cocaine abuse risk in adult SHR. "
09/21/2010 - "Methylphenidate (MPH) normalizes cortical function, enhancing task salience and improving associated cognitive abilities, in other frontal lobe pathologies; however, in clinical trials, MPH did not improve treatment outcome in cocaine addiction. "

01/01/2004 - "Randomized trial of buprenorphine for treatment of concurrent opiate and cocaine dependence."
01/01/1992 - "However, the trial by Kosten and associates has suggested a larger reduction in cocaine abuse at 6 mg than at 2 mg daily of buprenorphine. "
03/01/1991 - "The present results should provide some additional safety assurance in future clinical trials with buprenorphine, especially in outpatient trials where cocaine abuse may continue along with treatment."
05/01/2002 - "The effect of sublingual buprenorphine on cigarette smoking was examined in 23 adult men with DSM III-R diagnosis of concurrent opiate and cocaine dependence. "
10/01/1996 - "Three groups of male volunteers meeting DSM-III-R criteria for concurrent opiate and cocaine dependence were tested using an auditory oddball paradigm before and after detoxification, and again on the 15th day of either buprenorphine or placebo treatment. "

03/01/2010 - "Although other treatments are being explored, thus far, the combination of CBT and pharmacotherapy has elicited the best results for treating cocaine dependence with respect to patient retention and relapse prevention following abstinence. "
03/01/1994 - "At present, there is no consensus regarding effective treatment for cocaine abuse or the most productive roles for the two major forms of treatment, pharmacotherapy and psychotherapy. "
06/01/2002 - "Stress reduction, either alone or in combination with pharmacotherapies targeting the HPA axis may prove beneficial in reducing cravings and promoting abstinence in individuals seeking treatment for cocaine addiction."
01/01/2003 - "Given the difficulty of achieving sustained recovery, pharmacotherapy of opioid and cocaine addiction is more effective when combined with behavioral and psychosocial approaches. "
04/01/2011 - "Currently, there are no pharmacotherapies shown to be effective in the treatment of cocaine dependence. "

01/01/2006 - "There is currently no evidence that auricular acupuncture is effective for the treatment of cocaine dependence. "
01/01/2006 - "To determine whether auricular acupuncture is an effective treatment for cocaine dependence, and to investigate whether its effectiveness is influenced by the treatment regimen. "
02/01/2003 - "Because auricular acupuncture (AA) has been shown to be effective as an adjunct treatment to cocaine dependence, we wished to test the feasibility and potential efficacy of this treatment in depressed adolescents with repetitive SIB. "
01/01/2000 - "Auricular acupuncture is widely used for the treatment of cocaine addiction, and there is an urgent need to conduct controlled clinical research of this intervention. "
04/01/2002 - "To compare findings from two consecutive clinical trials of auricular acupuncture for cocaine addiction conducted at the same site in order to explore consistency of treatment effects. "

12/01/2009 - "In this study, we used intravenous drug self-administration procedures in rats to further investigate the beneficial effects of EE on cocaine addiction in a reinstatement model of relapse. "
10/01/2014 - "Correlates of polysomnographic sleep changes in cocaine dependence: self-administration and clinical outcomes."
07/01/2013 - "This differential response suggests that the endogenous cannabinoid system might contribute to genotype/strain differences on the sensitivity to self-administration training and cocaine addiction."
10/01/2003 - "One approach for studying cocaine addiction has been to permit escalating patterns of self-administration (SA) by rats by prolonging daily drug availability. "
07/01/2000 - "Alterations in neuroendocrine function associated with self-administration may be related to the development of cocaine dependence and could contribute to relapse in abstinent users."

04/11/2002 - "GBR compounds and mepyramines as cocaine abuse therapeutics: chemometric studies on selectivity using grid independent descriptors (GRIND)."
07/01/1997 - "Further, these studies may provide leads to novel therapeutics for the treatment of cocaine abuse."
03/01/2015 - "From a translational perspective, these findings underscore the importance of interventions and therapeutics targeting not just a brain region, but a specific computational process within that brain region, and may have implications for the design and implementation of more effective treatments for human cocaine addiction. "
06/01/2012 - "In addition, the development of promising cocaine addiction therapeutics derived from animal research will be reviewed."
01/01/1986 - "This sketch of the history of psychiatry since 1886 comprises the following points: cocaine addiction; psychoanalysis; sexology; psychiatric clinics and their recent abolition in Italy; nosology; heredity and environmental factors in mental disease; therapeutics."

04/01/2008 - "Recent advances in neurobiology, brain imaging and some clinical trials suggest that certain medications that modulate GABAergic, dopaminergic, and glutamatergic systems, as well as immunotherapy, show promise in the treatment of cocaine addiction. "
07/01/2008 - "Therefore, new concepts of cocaine abuse treatment resort to immunotherapy and biotechnology. "
02/01/1997 - "Immunotherapy for cocaine addiction."
09/01/2014 - "In the absence of any effective pharmacotherapy for cocaine addiction, immunotherapy is being actively pursued as a therapeutic intervention. "
04/01/2008 - "[Current pharmacotherapies and immunotherapy in cocaine addiction]."