Substance-Related Disorders (Drug Abuse)

Disorders related to substance use or abuse.

Also Known As:

Drug Abuse; Substance Abuse; Drug Addiction; Drug Dependence; Substance Dependence; Addiction, Drug; Addiction, Substance; Substance Use Disorder; Substance Use Disorders; Prescription Drug Abuse; Substance Addiction; Abuse, Drug; Abuse, Prescription Drug; Abuse, Substance; Chemical Dependences; Dependence, Chemical; Dependence, Drug; Dependence, Substance; Dependences, Chemical; Disorder, Drug Use; Disorder, Substance Related; Disorder, Substance Use; Disorders, Substance Related; Drug Abuse, Prescription; Habituation, Drug; Organic Mental Disorders, Substance Induced; Related Disorder, Substance; Related Disorders, Substance; Substance Abuses; Substance Uses; Use, Substance; Chemical Dependence; Drug Habituation; Drug Use Disorder; Drug Use Disorders; Organic Mental Disorders, Substance-Induced; Substance Related Disorder; Substance Use

Networked: 21181 relevant articles (785 outcomes, 3076 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Substance-Related Disorders (Drug Abuse)
2.	Pain (Aches)
3.	Mental Disorders (Mental Disorder)
4.	Schizophrenia (Dementia Praecox)
5.	Opioid-Related Disorders (Opiate Addiction)

Experts

1.	Weiss, Roger D: 55 articles (09/2022 - 02/2003)
2.	McCabe, Sean Esteban: 54 articles (01/2022 - 12/2004)
3.	Kranzler, Henry R: 54 articles (12/2021 - 01/2002)
4.	Degenhardt, Louisa: 53 articles (01/2022 - 03/2003)
5.	Wu, Li-Tzy: 50 articles (09/2022 - 03/2003)
6.	Gelernter, Joel: 50 articles (12/2021 - 01/2002)
7.	Saitz, Richard: 48 articles (07/2022 - 03/2000)
8.	Samet, Jeffrey H: 46 articles (12/2022 - 04/2002)
9.	Nunes, Edward V: 44 articles (05/2022 - 04/2004)
10.	Carroll, Kathleen M: 42 articles (01/2022 - 09/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Substance-Related Disorders:

1.	Opioid Analgesics (Opioids)IBA 01/01/2019 - "First, the most robust data supportive of the efficacy of NOP agonists in treating drug abuse come from studies in the field of alcohol research, followed by psychostimulant and opioid research. " 01/01/2022 - "As for substance use, a highly significant reduction in opioid use was observed (p = 0.003). " 04/01/2016 - "Challenges remain, however, including continued underutilization of services by those most in need, problems with treatment of substance use disorders, overuse of opioid medications, concerns with the structure of care for chronic postdeployment (including postconcussion) symptoms, and ongoing questions concerning the causes of historically high suicide rates, efficacy of resilience training initiatives, and research priorities. " 04/01/2014 - "The results show that SNPs in this locus are the most potent genetic factors associated with human opioid sensitivity known to date, affecting both the efficacy of opioid analgesics and liability to severe substance dependence. " 01/01/2014 - "These results show that SNPs in this locus are the most potent genetic factors associated with human opioid sensitivity known to date, affecting both the efficacy of opioid analgesics and liability to severe substance dependence. "
2.	Cocaine (Cocaine HCl)IBA 12/01/2007 - "Although improvement in psychosocial functioning is a common goal in substance-abuse treatment, the primary outcome measure in most cocaine trials is urinalysis-verified cocaine use. " 12/01/2023 - "EFT-based interventions may therefore have promise to reduce impulsive decision-making in individuals with cocaine use disorder with and without a significant history of incarceration, potentially supporting improved outcomes with respect to both substance use and future criminality." 11/01/1993 - "However, a significantly greater proportion of the alcohol and cocaine abusers admitted to having relapsed in the previous six months, reported significantly fewer average days of abstinence than the alcohol group since terminating treatment, and were more likely to present urine specimens indicative of recent substance abuse at the six-month follow-up interview. " 01/01/2017 - "These data demonstrate critical involvement of a sparse population of nNOS-expressing interneurons in cue-induced cocaine seeking, revealing a bottleneck in brain processing of drug-associated cues where therapeutic interventions could be effective in treating drug addiction. " 03/01/2013 - "Compared with living elsewhere, gay neighborhood residence appeared to be protective against cocaine use and substance dependence. "
3.	Methadone (Dolophine)FDA LinkGeneric 02/01/1977 - "It has been shown that while poor and middle class communities show good results with methadone maintenance approaches, in the area of secondary drug abuse they show marked dissimilarities. " 10/01/2022 - "Among Peer Activate participants, urine-verified methadone adherence reached 97% at post-intervention, and there was a significant reduction in substance use frequency from 48% of past two-week days used at baseline to 31.9% at post-intervention [t(25) = 1.82, p = .041]. " 05/01/2002 - "In conclusion, INH retention time and completion rates were significantly improved by methadone treatment combined with observed INH, whether or not substance abuse counseling was provided. " 11/01/2017 - "Overall, the addition of CM to standard methadone care improved substance use outcomes regardless of initial legal problems. " 01/01/2020 - "Initiating methadone treatment in jail was effective in promoting entry into community-based drug abuse treatment but subsequent treatment discontinuation attenuated any potential impact of such treatment."
4.	Antipsychotic Agents (Antipsychotics)IBA 11/01/2018 - "Childhood parental separation was associated with significantly greater likelihood of non-compliance with antipsychotic medications, compulsory admission, and substance dependence. " 08/01/2010 - "Although there is some preliminary evidence that atypical antipsychotic agents may be effective in treating substance dependence, results have been mixed, with some studies demonstrating positive and others negative or no effect. " 03/01/2001 - "However, there are few studies on the efficacy of antipsychotics on psychopathology and on their repercutions on substance abuse. " 09/01/2011 - "Intensification of psychotic symptoms was due to non-adherence to antipsychotic medication (67%), lack of efficacy of treatment (27%), and substance use (24%). " 03/01/1995 - "Some authors feel that substance abuse in schizophrenics might be due to extrapyramidal and other side-effects caused by neuroleptic treatment or inadequate remission of psychotic symptoms. "
5.	Hallucinogens (Psychedelics)IBA 09/27/2023 - "Psychedelics, also known as classical hallucinogens, have been investigated for decades due to their potential therapeutic effects in the treatment of neuropsychiatric and substance use disorders. " 01/01/2023 - "Psychedelics have garnered interest as a therapeutic class in other substance use disorders, and self-report surveys suggest they may result in positive outcomes for CUD. " 01/01/2016 - "Hallucinogen use and intimate partner violence: Prospective evidence consistent with protective effects among men with histories of problematic substance use." 03/01/2013 - "Some psychedelic compounds have been assessed as potential substance abuse treatments with promising results. " 12/05/2022 - "Hopelessness, Suicidality, and Co-Occurring Substance Use among Adolescent Hallucinogen Users-A National Survey Study."
6.	Buprenorphine (Subutex)FDA LinkGeneric 09/01/2015 - "The changes after the 2006 legislation suggest that policies focused on increasing the number of patients that a single waivered physician could safely and effectively treat could be more effective in increasing buprenorphine use than would alternatives such as opening new substance abuse treatment facilities or raising the overall number of waivered physicians." 09/01/2015 - "Policies relaxing patient limits may be more effective in increasing buprenorphine use than alternatives such as opening new substance abuse treatment facilities or increasing the overall number of waivered physicians. " 01/01/1993 - "These pharmacodynamic actions of buprenorphine may be relevant to its therapeutic efficacy in treating drug abuse and addiction." 08/01/2022 - "This trial will provide evidence of the efficacy of an integrated intervention combining CBT4CBT and Recovery Coaching for reducing substance use and increasing buprenorphine adherence which has the potential to reduce mortality among people with OUD." 08/01/2022 - "A pilot trial provided preliminary support for the efficacy of computer-based cognitive-behavioral therapy (CBT4CBT) as an add-on to buprenorphine in reducing substance use. "
7.	Nicotine FDA Link 10/01/2021 - "Non-nicotine substance use and more frequent JUUL use was associated with significantly greater odds of dependence and more severe dependence symptoms in multivariable models. " 01/01/2018 - "Significant reduction in substance use of nicotine (66.1%) and alcohol (56.0%) was reported on follow-up. " 01/01/2022 - "We found that the TMI helped to reduce secondary substance use behaviors and mental health symptoms among the participants; mainly there were medium effects of the intervention on changes in other tobacco/nicotine use, drinking, and anxiety and depression symptoms. " 02/01/2009 - "This article tests the hypothesis that remission from substance use disorders is associated with smoking cessation in nicotine dependent young adults. " 02/01/2009 - "Does remission from alcohol and drug use disorders increase the likelihood of smoking cessation among nicotine dependent young adults?"
8.	Methamphetamine (Desoxyn)FDA LinkGeneric 01/01/2023 - "Community-based approaches have proven effective in tackling diverse health-related challenges including substance use; however, little is known regarding community programs targeting methamphetamine use. " 05/01/2020 - "This study investigated how improving executive functions (EFs) impacts methamphetamine-use disorder, which has been less explored compared to craving, but might be a central aspect for the therapeutic efficacy of DLPFC stimulation in drug addiction. " 08/01/2021 - "Increased prevention efforts are needed, including prevention of methamphetamine initiation among adolescents and young adults, improved access to effective treatment for co-occurring mental health and substance use disorders, and prevention of unintentional exposures among children." 01/01/2017 - "The Matrix model of substance use treatment has been evaluated extensively in the United States as an effective treatment for methamphetamine use disorders. " 01/01/2021 - "To evaluate whether cognitive performance in adults with active methamphetamine use (MA-ACT) differs from cognitive performance in adults in remission from MA use disorder (MA-REM) and adults without a history of substance use disorder (CTLs). "
9.	Heroin (Diamorphine)IBA 01/01/2016 - "This study was designed to determine if 12-Steps groups efficacy for substance abuse treatment significantly improve abstinence rates of heroin addicts in the short run and long run (1-year and 5-year period); and if abstinence rates are found to be lower for heroin addicts that have attended 12-Step groups at the 1-year mark, and if similar results would be expected at the 5-year mark. " 10/01/2011 - "Drug assertiveness skills have been demonstrated to be effective in reducing substance use behaviors among patients with alcohol or heroin use disorders. " 01/01/2015 - "Risk-conferring effects of S1-S3 and S5-S29 crossovers and protective effects of S3-S5 crossover were seen in both pure heroin dependent and multiple substance dependence subgroups. " 01/01/2015 - "Furthermore, this study suggests that the assessment of amygdala-related connectivity during fear processing may provide a prognostic tool to assess stress levels in heroin-dependent patients and to quantify the efficacy of maintenance treatments in drug addiction. " 10/01/2016 - "Screening, Brief Intervention, and Referral to Treatment (SBIRT) is a model which shows promise for preventing initiation and reducing risky substance use among adolescents before it progresses to use of harder drugs such as heroin. "
10.	Antidepressive Agents (Antidepressants)IBA 04/01/1995 - "When treated by either black or white clinicians, black veterans had poorer attendance than white veterans, seemed less committed to treatment, received more treatment for substance abuse, were less likely to be prescribed antidepressant medications, and showed less improvement in control of violent behavior. " 11/01/2004 - "Review: antidepressants are moderately effective in people with depression and a substance dependence disorder." 01/01/1994 - "Several studies show antidepressant effects, but none demonstrate clear improvement in drug abuse. " 04/04/2005 - "Efficacy of antidepressants in substance use disorders with and without comorbid depression. " 04/21/2004 - "To conduct a systematic review and meta-analysis to quantify the efficacy of antidepressant medications for treatment of combined depression and substance use disorders. "

Therapies and Procedures

1.	Therapeutics 01/01/2009 - "Although integrated treatment with the inclusion of cognitive-behavioural therapy, motivational interviewing and family intervention in DD treatment show promising results, it remains to establish which treatment programme is the most qualified in improving mental health and reducing substance use. " 10/01/2005 - "Rigorous research has recently identified a range of behavioral therapies that have been shown to be effective across the most prevalent types of substance dependence. " 04/01/1981 - "However, there was one exception: improvement in psychological function was clearly related to general improvement in most other areas, including chemical abuse, indicating the potential importance of psychologically oriented therapy in substance abuse treatment. " 10/03/2013 - "We found no significant differences on loss to treatment (n = 603, 3 RCTs, RR 1.09 CI 0.82 to 1.45, low quality of evidence), death by 3 years (n = 421, 2 RCTs, RR 1.18 CI 0.39 to 3.57, low quality of evidence), alcohol use (not in remission at 36 months) (n = 143, 1 RCT, RR 1.15 CI 0.84 to 1.56,low quality of evidence), substance use (n = 85, 1 RCT, RR 0.89 CI 0.63 to 1.25, low quality of evidence), global assessment of functioning (n = 171, 1 RCT, MD 0.7 CI 2.07 to 3.47, low quality of evidence), or general life satisfaction (n = 372, 2 RCTs, MD 0.02 higher CI 0.28 to 0.32, moderate quality of evidence).For evaluation of non-integrated intensive case management with usual treatment (4 RCTs, n = 163) we found no statistically significant difference for loss to treatment at 12 months (n = 134, 3 RCTs, RR 1.21 CI 0.73 to 1.99, very low quality of evidence).Motivational interviewing plus cognitive behavioural therapy compared to usual treatment (7 RCTs, total n = 878) did not reveal any advantage for retaining participants at 12 months (n = 327, 1 RCT, RR 0.99 CI 0.62 to 1.59, low quality of evidence) or for death (n = 493, 3 RCTs, RR 0.72 CI 0.22 to 2.41, low quality of evidence), and no benefit for reducing substance use (n = 119, 1 RCT, MD 0.19 CI -0.22 to 0.6, low quality of evidence), relapse (n = 36, 1 RCT, RR 0.5 CI 0.24 to 1.04, very low quality of evidence) or global functioning (n = 445, 4 RCTs, MD 1.24 CI 1.86 to 4.34, very low quality of evidence).Cognitive behavioural therapy alone compared with usual treatment (2 RCTs, n = 152) showed no significant difference for losses from treatment at 3 months (n = 152, 2 RCTs, RR 1.12 CI 0.44 to 2.86, low quality of evidence). " 10/07/2019 - "In comparison to an adolescent substance abuse therapy, one study (112 participants) found significant reduction in re-arrests up to 24 months (MD 0.24, 95% CI 0.76 to 0.28), based on low-certainty evidence.One"
2.	Secondary Prevention 04/01/2017 - "The most and the least improved areas of knowledge were relapse prevention and substance use screening, respectively. " 10/01/2020 - "Mindfulness-based relapse prevention (MBRP) for substance use disorders (SUDs) appears to be particularly effective among individuals with high levels of co-occurring affective symptoms. " 08/01/2008 - "And should we investigate whether the provision of secondary prevention for vulnerable families which address major contributing factors, such as parental substance dependence and mental health issues are effective in reducing abuse of children in these families?" 01/01/2022 - "In this paper, we further develop the theoretical model and elaborate on seven elements that were found effective in the psychosocial interventions with individuals with BD: monitoring mood and early symptoms of relapse, recognizing and management of stressful situations and interpersonal conflicts, creating a relapse prevention plan, stabilizing the sleep/wake cycle and daily routine, encouraging the use of medication, and reducing self-stigma and substance use. " 06/01/2019 - "Mindfulness-based relapse prevention (MBRP) is an effective treatment for substance use disorders (SUD). "
3.	Drug Therapy (Chemotherapy) 01/01/2021 - "Because the available treatments show very limited effectiveness, evaluating the drug efficacy of AMPK and mTOR specific modulators opens up the possibility of testing novel pharmacotherapies for an individualized approach in drug abuse." 01/01/2019 - "Pharmacotherapy includes a growing number of clinically effective medications for substance use disorder, yet there are significant barriers to its adoption and implementation in routine clinical practice. " 01/01/2013 - "Overall, findings from the relatively small amount of available data indicate that pharmacotherapy for managing mood symptoms can be effective in patients with substance dependence, although results have not been consistent across all studies. " 10/01/2008 - "Furthermore, advancements in the understanding of the genetic and epigenetic basis of drug addiction and the pharmacogenetics of the safety and/or efficacy of the medications are providing opportunities for more individualized pharmacotherapy approaches. " 01/01/2005 - "Further research is needed to better understand the feasibility and efficacy of providing pharmacotherapies for substance dependence disorders within this population."
4.	Meditation 08/01/2014 - "It has been demonstrated that mindfulness meditation can improve the regulation of NA, suggesting that mindfulness may be very beneficial in treating problematic substance use behavior. " 08/01/2010 - "From a clinical viewpoint, Mindfulness-Based Stress Reduction (MBSR) has shown efficacy for many psychiatric and physical conditions and also for healthy subjects, Mindfulness-Based Cognitive Therapy (MBCT) is mainly efficacious in reducing relapses of depression in patients with three or more episodes, Zen meditation significantly reduces blood pressure and Vipassana meditation shows efficacy in reducing alcohol and substance abuse in prisoners. " 07/01/2007 - "Common findings included an inverse relationship between religiosity and substance use/abuse, reduced use among those practising meditation and protective effects of 12-Step group involvement during recovery. " 01/01/2009 - "A brief discussion then integrates the research that has been completed thus far, elucidates the specific ways that meditation may be helpful for substance use disorders, and suggests new avenues for research." 01/01/2022 - "Background: Two Way Prayer Meditation (TWPM) is a spiritual intervention that holds promise for improving the psychospiritual well-being of individuals in recovery from substance use disorders (SUD). "
5.	Self Administration (Administration, Self) 04/01/2020 - "Drug self-administration procedures are the gold standard for laboratory research to study mechanisms of drug use disorders and evaluate candidate medications. " 09/01/2020 - "Drug self-administration has been regarded as a gold-standard preclinical model of addiction and substance-use disorder (SUD). " 01/01/2020 - "Intravenous drug self-administration is considered the "gold standard" model to investigate the neurobiology of drug addiction in rodents. " 12/01/2023 - "Rat intravenous self-administration is a widely-used animal model in the study of substance use disorders. " 01/01/2022 - "Previous studies show that intermittent social defeat (ISD) stress increases self-administration of psychostimulants, which suggests that ISD promotes reward-seeking behavior and, ultimately, increases vulnerability to develop drug abuse. "