DNA Polymerase beta (DNA Polymerase IV)

08/01/2004 - "Combined with the small-scale tumor studies, these mechanistic studies implicate variant forms of DNA polymerase beta in the etiology of human cancer."
10/01/2003 - "[Study on DNA polymerase beta gene mutation in human cervical cancer]."
05/01/2009 - "Yet, approximately thirty percent of human tumor types show variants of DNA polymerase beta. "
01/01/2009 - "Altered expression of DNA polymerase beta (Pol beta) has been documented in a large percentage of human tumors. "
04/01/2007 - "Loading of DNA polymerase-beta into the replication forks generates a death signal, which involves the tumor suppressor p53. "

07/01/2002 - "[A study of DNA polymerase beta mutation in human esophageal cancer]."
01/01/2006 - "Difference in expression level and localization of DNA polymerase beta among human esophageal cancer focus, adjacent and corresponding normal tissues."
07/01/2002 - "To investigate whether DNA polymerase beta (POLB) gene mutations occur in esophageal cancer. "
01/01/2006 - "The aim of this paper was to study the expression level and localization of DNA polymerase beta (polbeta) and the difference in those among the human esophageal cancer focus, cancer adjacent and corresponding normal esophageal tissues. "
02/01/2013 - "DNA polymerase beta promoter mutations affect gene transcription, translation and the sensitivity of esophageal cancer cells to cisplatin treatment."

01/01/2012 - "Association of a newly identified variant of DNA polymerase beta (polβΔ63-123, 208-304) with the risk factor of ovarian carcinoma in India."
01/01/2012 - "Association of two polymorphisms of DNA polymerase beta in exon-9 and exon-11 with ovarian carcinoma in India."
02/01/2008 - "The Leu22Pro (L22P) DNA polymerase beta variant was identified in a gastric carcinoma. "
08/14/2005 - "To observe the variation of DNA polymerase beta (polbeta) in esophageal carcinoma. "
08/14/2005 - "Mutation of DNA polymerase beta in esophageal carcinoma of different regions."

09/15/2015 - "Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks."
01/01/2015 - "Clinical significance of a point mutation in DNA polymerase beta (POLB) gene in gastric cancer."
01/01/2012 - "It has been shown that more than thirty percent of breast, bladder, esophageal, colon, and gastric cancer samples studied so far have exhibited DNA polymerase beta mutation. "
08/01/2007 - "The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation."
10/22/1999 - "Functional mutation of DNA polymerase beta found in human gastric cancer--inability of the base excision repair in vitro."

06/01/2007 - "Polymorphisms of the DNA polymerase beta gene in breast cancer."
11/01/2004 - "We conclude that expression of the DNA polymerase beta variant (pol betadelta208-236) is ubiquitous and not breast cancer specific."
11/01/2004 - "DNA polymerase beta transcripts were analyzed in 8 breast cancer cell lines, snap-frozen benign breast tissues from 10 women, and lymphocytes from 10 normal controls, using reverse-transcription polymerase chain reaction (RT-PCR) and three separate primer pairs. "
11/26/1999 - "DNA polymerase beta gene mutation in human breast cancer."
08/01/2008 - "In the present study, we show that both elevated MPG expression and short hairpin RNA-mediated loss of DNA polymerase beta (Pol beta) expression in human breast cancer cells increases cellular sensitivity to temozolomide. "