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Mitogen-Activated Protein Kinase 1 (p42 MAP Kinase)

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A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.

Also Known As:

p42 MAP Kinase; MAPK1 Mitogen-Activated Protein Kinase; MAPK2 Mitogen-Activated Protein Kinase; p42(Mapk); p42(Mapk) Kinase; Extracellular Signal Regulated Kinase 2; MAP Kinase, p42; MAPK1 Mitogen Activated Protein Kinase; MAPK2 Mitogen Activated Protein Kinase; Mitogen Activated Protein Kinase 1; Mitogen Activated Protein Kinase 2; Extracellular Signal-Regulated Kinase 2; MAP Kinase 2; Mitogen-Activated Protein Kinase 2; p42 MAPK; p42(Mitogen-Activated Protein Kinase)

Networked: 112 relevant articles (3 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kozawa, Osamu: 4 articles (01/2016 - 06/2009)
2.	Tanabe, Kumiko: 3 articles (01/2016 - 06/2009)
3.	Madak-Erdogan, Zeynep: 3 articles (01/2014 - 01/2011)
4.	Katzenellenbogen, Benita S: 3 articles (01/2014 - 01/2011)
5.	Lee, Jiing-Dwan: 3 articles (06/2011 - 11/2004)
6.	Iida, Hiroki: 2 articles (01/2016 - 06/2012)
7.	Xu, Qinghao: 2 articles (02/2010 - 12/2008)
8.	Shin, Sarah J: 2 articles (02/2010 - 12/2008)
9.	Weyerbacher, Amanda R: 2 articles (02/2010 - 12/2008)
10.	Inturrisi, Charles E: 2 articles (02/2010 - 12/2008)

Related Diseases

1.	Sclerosis 04/01/2010 - "Repeated intraperitoneal administration of a mitogen-activated protein kinase 1 (MAPK1) siRNA/nanocarrier complex suppressed glomerular MAPK1 mRNA and protein expression in a mouse model of glomerulonephritis; this improved kidney function, reduced proteinuria, and ameliorated glomerular sclerosis. "
2.	Proteinuria 04/01/2010 - "Repeated intraperitoneal administration of a mitogen-activated protein kinase 1 (MAPK1) siRNA/nanocarrier complex suppressed glomerular MAPK1 mRNA and protein expression in a mouse model of glomerulonephritis; this improved kidney function, reduced proteinuria, and ameliorated glomerular sclerosis. "
3.	Glomerulonephritis 04/01/2010 - "Repeated intraperitoneal administration of a mitogen-activated protein kinase 1 (MAPK1) siRNA/nanocarrier complex suppressed glomerular MAPK1 mRNA and protein expression in a mouse model of glomerulonephritis; this improved kidney function, reduced proteinuria, and ameliorated glomerular sclerosis. "
4.	Carcinoid Tumor (Carcinoid) 06/01/2005 - "Treatment of carcinoid tumor cells with ZM336372 resulted in progressive phosphorylation of Raf-1, mitogen-activated protein kinase 1/2, and extracellular signal-regulated kinase 1/2. Importantly, exposure to ZM336372 resulted in a significant reduction of bioactive hormone levels as well as the transcription factor, human achaete-scute homologue-1 in carcinoid tumor cells. "
5.	Arteriosclerosis 03/01/2013 - "Adenovirus-mediated anti-sense extracellular signal-regulated kinase 2 gene therapy inhibits activation of vascular smooth muscle cells and angiogenesis, and ameliorates transplant arteriosclerosis."

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	Mitogen-Activated Protein Kinase 3
3.	Messenger RNA (mRNA)
4.	Hormones
5.	Transcription Factors (Transcription Factor)
6.	N- (5- (3- dimethylaminobenzamido)- 2- methylphenyl)- 4- hydroxybenzamide
7.	Phosphotransferases (Kinase)
8.	Tyrosine (L-Tyrosine)
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
10.	Estrogens (Estrogen)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Homologous Transplantation (Allograft)
3.	Therapeutics
4.	Analgesia
5.	Activator Appliances (Function Activator)