Cyclin A

A cyclin subtype that has specificity for CDC2 PROTEIN KINASE and CYCLIN-DEPENDENT KINASE 2. It plays a role in progression of the CELL CYCLE through G1/S and G2/M phase transitions.

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Networked: 631 relevant articles (8 outcomes, 74 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nesland, J M: 8 articles (03/2009 - 09/2000)
2.	Fjällskog, Marie-Louise: 5 articles (01/2013 - 09/2009)
3.	Ahlin, Cecilia: 5 articles (01/2013 - 09/2009)
4.	Coleman, Nicholas: 5 articles (03/2010 - 10/2003)
5.	van Diest, Paul J: 5 articles (08/2007 - 11/2002)
6.	Bukholm, G: 5 articles (01/2006 - 07/2001)
7.	Fitzgerald, Rebecca C: 4 articles (11/2015 - 11/2004)
8.	Auer, Gert: 4 articles (08/2015 - 11/2003)
9.	Blomqvist, C: 4 articles (02/2015 - 09/2005)
10.	Bendahl, Pär-Ola: 4 articles (01/2013 - 09/2004)

Related Diseases

1.	Neoplasms (Cancer) 08/25/2009 - "In contrast, patients who had positive results for ER-alpha and PR-B, and negative results for cyclin A and p53 had favorable characteristics, such well differentiated tumor, early clinical stage, negative LVSI, and less MI, and had a good prognosis. " 11/15/2003 - "High cyclin A expression (>19% positive cancer cell nuclei, the highest tertile) was associated with a high rate of locoregional tumor recurrence and unfavorable disease-free and overall survival as compared with cases with a lower expression (p = 0.025, 0.032, and 0.042, respectively). " 11/01/2000 - "Positive cyclin A showed a significantly greater increase in T4 tumors than in those of other stages, and negative p27 showed a significantly greater decrease in T4 tumors than in large T3 stage tumors (tumor size > or = 4.0 cm). " 06/01/2014 - "In this study, we show that cyclin A expression correlates with tumor grade and FIGO stage. " 07/01/2011 - "In the present study we evaluated the prognostic significance of cyclin A and B1 in correlation with Ki-67 index in pediatric embryonal tumors. "
2.	Adenocarcinoma 01/15/2007 - "A cross-sectional cyclin A immunostaining study was done in 77 patients attending for BE surveillance and 17 patients undergoing evaluation of esophageal adenocarcinoma. " 03/01/2011 - "Multivariate analysis, including age and sex, showed that cyclin A expression was independently correlated with nuclear expression of Yes-associated protein in adenocarcinomas. " 04/01/2009 - "In immunocytochemistry for p53 protein, Ki-67, and cyclin A, the material consists of 40 cases of cytologic smears examined by direct sampling of the endometrial cavity comprising 30 cases of ECC in endometrial glandular and stromal breakdown (EGBD) and 10 cases of well-differentiated adenocarcinoma (G1). " 01/15/2007 - "In the case-control cohort, patients with biopsies expressing cyclin A at the surface were more likely to progress to adenocarcinoma than those who did not (odds ratio, 7.5; 95% confidence interval, 1.8-30.7). " 11/01/2005 - "Intratumoral heterogeneous expression of p53 correlates with p53 mutation, Ki-67, and cyclin A expression in endometrioid-type endometrial adenocarcinomas."
3.	Neoplasm Metastasis (Metastasis) 08/01/2014 - "Both cyclin A and WHO 2010 grade were very specific in identifying patients at risk for metastasis (100% versus 96%). " 01/01/2012 - "HuR cytoplasmic expression was significantly related to the pT status, lymph node metastasis, a higher histological grade, the pattern of invasion, vascular and perineurial invasion, and cyclin A expression (p = 0.005). " 01/01/2012 - "The results of cytoplasmic HuR and nuclear cyclin A expressions were correlated with disease-specific survival (DSS), metastasis-free survival (MeFS), urinary bladder recurrence-free survival (UBRFS), and various clinicopathological factors. " 08/05/2008 - "The frequency of Ki67-positive cells was found to be highly correlated with the frequency of cyclin A-positive cells, and both proliferation markers were equally good to predict risk of distant metastases. " 03/01/2008 - "In LSCC, a statistically significant correlation was found between enhanced cyclin A expression and a higher incidence of locoregional lymph node metastasis (p0.01). "
4.	Ulcerative Colitis 01/01/2006 - "Bottom-up cell proliferation with cyclin A and p27Kip1 expression in ulcerative colitis-associated dysplasia." 11/01/2003 - "The average number of copy alterations correlates with increased cyclin A levels (P=0.044), which is an independent predictor of risk of carcinoma development in ulcerative colitis. " 07/01/2001 - "Combined nuclear DNA assessment, laminin-5 gamma2 chain and cyclin A expression may help to identify ulcerative colitis patients with an increased risk for cancer development." 01/01/2006 - "To analyze the cell kinetics of ulcerative colitis (UC)-associated dysplasia, cyclin A, cyclin D1, cyclin E, cdk2, cdk4, p21(Waf1), and p27(Kip1) were immunohistochemically examined, in comparison with sporadic tubular adenomas. " 07/01/2001 - "Ulcerative colitis and colorectal carcinoma: DNA-profile, laminin-5 gamma2 chain and cyclin A expression as early markers for risk assessment."
5.	Squamous Cell Neoplasms (Squamous Cell Cancer) 09/01/2003 - "The analyzed material consisted of histological sections from different squamous cell cancers that had stained for proliferation using Ki-67 and cyclin A detection. " 03/01/2008 - "The determination of cyclin A expression might be helpful in the identification of laryngeal squamous cell cancer (LSCC) patients with increased risk of metastases. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Cyclin C
3.	Phenol (Carbolic Acid)
4.	kalinin
5.	Cyclin E
6.	Proteins (Proteins, Gene)
7.	Cyclin D1
8.	Phosphotransferases (Kinase)
9.	Cyclins
10.	Cyclin B1

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Radiotherapy
4.	Cardiopulmonary Resuscitation (CPR)
5.	Radical Mastectomy