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DNA Primase (Primase)

Subscribe to New Research on DNA Primase

A single-stranded DNA-dependent RNA polymerase that functions to initiate, or prime, DNA synthesis by synthesizing oligoribonucleotide primers. EC 2.7.7.-.

Also Known As:

Primase; DnaG (Primase); Bacteriophage T7 Gene 4 Protein; DnaG Gene Product; DnaG Protein; T7 DNA Primase-Helicase Protein; T7 DNA-Priming Protein; T7 gene-4 protein; DNA-Priming Protein, T7; Primase, DNA; Protein, T7 DNA-Priming; T7 DNA Primase Helicase Protein; T7 DNA Priming Protein; T7 gene 4 protein

Networked: 80 relevant articles (9 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Transferases: 4296
    - Phosphotransferases: 30637
      - Nucleotidyltransferases: 1
        RNA Nucleotidyltransferases
        DNA-Directed RNA Polymerases: 1071
        DNA Primase: 80
        DNA polymerase alpha-primase: 13
        human DNA primase p58 subunit
        Human herpesvirus 1 helicase-primase
        mouse Prim2 protein
        primase-reverse transcriptase complex
        Pyrococcus DNA primase

Experts

1.	Field, Hugh J: 6 articles (07/2014 - 08/2007)
2.	Suzuki, Hiroshi: 6 articles (04/2013 - 08/2010)
3.	Kuchta, Robert D: 5 articles (10/2013 - 07/2004)
4.	Chono, Koji: 5 articles (03/2013 - 08/2010)
5.	Cheng, Hans H: 4 articles (05/2015 - 06/2014)
6.	Dunn, John R: 4 articles (05/2015 - 06/2014)
7.	Hildebrandt, Evin: 4 articles (05/2015 - 06/2014)
8.	Biswas, Subhajit: 4 articles (07/2014 - 08/2007)
9.	Kontani, Toru: 4 articles (03/2013 - 08/2010)
10.	Katsumata, Kiyomitsu: 4 articles (03/2013 - 08/2010)

Related Diseases

1.	Infection 01/01/2015 - "Helicase-primase as a target of new therapies for herpes simplex virus infections." 07/01/2014 - "Pharmacokinetics-pharmacodynamics of the helicase-primase inhibitor pritelivir following treatment of wild-type or pritelivir-resistant virus infection in a murine herpes simplex virus 1 infection model." 04/24/2014 - "Helicase-primase inhibitor pritelivir for HSV-2 infection." 01/16/2014 - "Pritelivir, an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. " 01/16/2014 - "Helicase-primase inhibitor pritelivir for HSV-2 infection."
2.	Herpetic Keratitis 04/01/2013 - "To determine the efficacy of a new helicase-primase inhibitor, ASP2151, for treating herpetic keratitis. " 04/01/2013 - "Efficacy of herpes virus helicase-primase inhibitor, ASP2151, for treating herpes simplex keratitis in mouse model." 02/01/2008 - "Efficacy of a helicase-primase inhibitor in animal models of ocular herpes simplex virus type 1 infection."
3.	Marek Disease (Marek's Disease) 03/01/2015 - "The Mut UL5-I682R Marek's Disease Virus with a Single Nucleotide Mutation Within the Helicase-Primase Subunit Gene not only Reduces Virulence but also Provides Partial Vaccinal Protection Against Marek's Disease." 05/04/2015 - "Characterizing in vivo stability and potential interactions of a UL5 helicase-primase mutation previously shown to reduce virulence and in vivo replication of Marek's disease virus." 06/01/2014 - "Characterizing the molecular basis of attenuation of Marek's disease virus via in vitro serial passage identifies de novo mutations in the helicase-primase subunit gene UL5 and other candidates associated with reduced virulence." 01/01/2015 - "Addition of a UL5 helicase-primase subunit point mutation eliminates bursal-thymic atrophy of Marek's disease virus ∆Meq recombinant virus but reduces vaccinal protection."
4.	Herpes Genitalis (Genital Herpes) 07/01/2012 - "Taken together, these results demonstrate that ASP2151 inhibits the replication of HSV clinical isolates more potently than ACV, and HSV resistant to this novel helicase-primase inhibitor as well as ACV may not easily emerge in short-term treatment for recurrent genital herpes patients." 07/01/2012 - "Susceptibility of herpes simplex virus isolated from genital herpes lesions to ASP2151, a novel helicase-primase inhibitor." 01/01/2011 - "Effect of ASP2151, a herpesvirus helicase-primase inhibitor, in a guinea pig model of genital herpes." 01/01/2007 - "Superior efficacy of helicase-primase inhibitor BAY 57-1293 for herpes infection and latency in the guinea pig model of human genital herpes disease."
5.	Human Influenza (Influenza) 11/15/2013 - "In this second part of "Dancing with antivirals as chemical formulae" I will focus on a number of chemical compounds that in the last few years have elicited more than common attraction from a commercial viewpoint: (i) favipiravir (T-705), as it is active against influenza, but also several other RNA viruses; (ii) neuraminidase inhibitors such as zanamivir and oseltamivir; (iii) peramivir and laninamivir octanoate, which might be effective against influenza virus following a single (intravenous or inhalation) administration; (iv) sofosbuvir, the (anticipated) cornerstone for the interferon-free therapy of HCV infections; (v) combinations of DAAs (direct antiviral agents) to achieve, in no time, a sustained virus response (SVR) against HCV infection; (vi) HIV protease inhibitors, the latest and most promising being darunavir; (vii) the integrase inhibitors (INIs) (raltegravir, elvitegravir, dolutegravir), representing a new dimension in the anti-HIV armamentarium; (viii), a new class of helicase primase inhibitors (HPIs) that may exceed acyclovir and the other anti-herpes compounds in both potency and safety; (ix) CMX-001, as the latest of Dr. Antonín Holý's legacy for its activity against poxviruses and CMV infections, and (x) noroviruses for which the ideal antiviral compounds are still awaited for. "

Related Drugs and Biologics

1.	Acyclovir (Aciclovir)
2.	BAY 57-1293
3.	Antiviral Agents (Antivirals)
4.	BILS 45 BS
5.	cidofovir hexadecyloxypropyl ester
6.	Zanamivir (Relenza)
7.	Oseltamivir (Tamiflu)
8.	Integrase Inhibitors
9.	HIV Protease Inhibitors
10.	Thymidine Kinase

Related Therapies and Procedures

1.	Inhalation Administration