Proto-Oncogene Proteins c-raf

A ubiquitously expressed raf kinase subclass that plays an important role in SIGNAL TRANSDUCTION. The c-raf Kinases are MAP kinase kinase kinases that have specificity for MAP KINASE KINASE 1 and MAP KINASE KINASE 2.

Also Known As:

Kinase Raf-1; Kinase p74(raf-1); Proto-Oncogene Protein c-raf; c-raf Kinases; cRaf1 Kinase; raf-1 Kinase; Kinase Raf 1; Kinase, cRaf1; Kinase, raf-1; Kinases, c-raf; Protein c-raf, Proto-Oncogene; Proteins c-raf, Proto-Oncogene; Proteins, c-raf; Proto Oncogene Protein c raf; Proto Oncogene Proteins c raf; Raf-1, Kinase; c raf Kinases; c raf Proteins; c-raf, Proto-Oncogene Protein; c-raf, Proto-Oncogene Proteins; raf 1 Kinase; c-raf Proteins

Networked: 91 relevant articles (3 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kim, Youn Wha: 9 articles (03/2015 - 10/2010)
2.	Bonavida, Benjamin: 8 articles (01/2018 - 10/2007)
3.	Kim, Hyun-Soo: 6 articles (03/2015 - 12/2010)
4.	Lugli, Alessandro: 6 articles (12/2013 - 05/2007)
5.	Zlobec, Inti: 6 articles (12/2013 - 05/2007)
6.	Baritaki, Stavroula: 6 articles (06/2012 - 10/2007)
7.	Park, Yong-Koo: 5 articles (10/2012 - 11/2010)
8.	Kim, Gou Young: 5 articles (05/2012 - 11/2010)
9.	Labbozzetta, Manuela: 4 articles (01/2021 - 05/2011)
10.	Notarbartolo, Monica: 4 articles (01/2021 - 05/2011)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "The lack of Raf-1 kinase feedback regulation enhances antiapoptosis in cancer cells." 09/01/1998 - "Raf-1 kinase activity was inversely correlated (P = 0.001) with SF2 values in the 12 cervical tumor clones studied. " 04/01/1998 - "Raf-1 kinase activity was increased about four-fold in liver tumors as compared with normal liver tissue. " 04/01/1998 - "To allow for determination of Raf-1 kinase activity in tumors, a sensitive and specific assay was developed for measurements with tissue homogenates. " 06/01/1996 - "The tumor and mucosa samples did not differ significantly with regard to Raf-1 kinase content and activity. "
2.	Breast Neoplasms (Breast Cancer) 12/01/1998 - "The results show that E2 can induce raf-1 kinase activity in MCF-7 breast cancer cells associated with the expression of an early growth response gene and modulation of ER signalling." 01/01/1995 - "Baseline expression of the 74-kDa or activated form of the Raf-1 kinase appeared to be elevated in the breast cancer cells studied, indicating constitutive activation. " 01/01/1995 - "The role of Raf-1 kinase in breast cancer has not been studied. " 01/01/2013 - "Clinical implications for loss or diminution of expression of Raf-1 kinase inhibitory protein and its phosphorylated form in ductal breast cancer." 04/10/2003 - "Down-regulation of Raf-1 kinase is associated with paclitaxel resistance in human breast cancer MCF-7/Adr cells."
3.	Ovarian Neoplasms (Ovarian Cancer) 07/01/2000 - "However, in the ovarian cancer cell lines (CA-OV3, SK-OV3, 2780/CP and OAW42/CP) that have a mutant TP53 (TP53mut), the cytotoxicity induced by 60 nM paclitaxel exhibited the same relationship to Raf-1 kinase activity as previously observed in cervical tumor cell lines. " 07/01/2000 - "The relationship between Raf-1 kinase activity and the sensitivity to clinically relevant paclitaxel concentrations was determined in four ovarian cancer cell lines (CA-OV3, SK-OV3, 2780/WT and OAW42/WT). " 07/01/2000 - "In light of the possibility that Raf-1 kinase inhibitors could be used to enhance paclitaxel responsiveness in ovarian cancer, we have characterized the Raf-1 kinase dependency of paclitaxel resistance in ovarian cancer cells. " 07/01/2000 - "Raf-1 kinase activity predicts for paclitaxel resistance in TP53mut, but not TP53wt human ovarian cancer cells." 07/01/2000 - "These data suggest that the therapeutic efficacy of paclitaxel in ovarian cancer patient whose tumors have TP53mut might be increased if it is administered in combination with Raf-1 kinase inhibitors, e.g., ISIS 5132."
4.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/01/2018 - "Here, we demonstrate that Raf-1 kinase inhibitor protein (RKIP) deficiency in mice ameliorates the symptoms of experimental autoimmune encephalomyelitis (EAE). "
5.	Colorectal Neoplasms (Colorectal Cancer) 05/28/2013 - "This study evaluates the geographic expression pattern of Raf-1 Kinase Inhibitor Protein (RKIP) in colorectal cancer (CRC) in correlation with clinicopathological and molecular features, markers of epithelial-mesenchymal transition (EMT) and survival outcome. " 07/01/2012 - "Reduced expression of Raf-1 kinase inhibitor protein (RKIP) has been documented in a number of human malignancies, including colorectal carcinoma (CRC). " 01/01/2008 - "Node-negative colorectal cancer at high risk of distant metastasis identified by combined analysis of lymph node status, vascular invasion, and Raf-1 kinase inhibitor protein expression." 06/01/1996 - "In this study, the expression of EGFR and mutant Ras proteins, and, for the first time, the expression, phosphorylation and kinase activity of Raf-1 kinase have been determined in paired samples of colorectal cancer and mucosa. " 05/01/2007 - "Loss of raf-1 kinase inhibitor protein expression is associated with tumor progression and metastasis in colorectal cancer."

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	Proteins (Proteins, Gene)
3.	ISIS 5132
4.	Phosphotransferases (Kinase)
5.	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)
6.	Mitogens
7.	ras Proteins
8.	ErbB Receptors (EGF Receptor)
9.	Mitogen-Activated Protein Kinase Kinases (MEKs)
10.	Ephrin-B2 (Ephrin B2)

Related Therapies and Procedures

1.	Neck Dissection (Radical Neck Dissection)
2.	Thyroidectomy
3.	Therapeutics
4.	Radiotherapy
5.	Drug Therapy (Chemotherapy)