Ribosomal Protein S6 Kinases (S6 Kinase)

A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases.

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Networked: 292 relevant articles (4 outcomes, 32 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Thomas, George: 7 articles (07/2015 - 10/2002)
2.	Kimball, Scot R: 6 articles (11/2015 - 09/2003)
3.	Nguyen, Hanh V: 6 articles (08/2013 - 09/2003)
4.	Suryawan, Agus: 6 articles (08/2013 - 09/2003)
5.	Davis, Teresa A: 6 articles (08/2013 - 09/2003)
6.	Pende, Mario: 5 articles (07/2015 - 06/2007)
7.	Orellana, Renán A: 5 articles (08/2013 - 09/2003)
8.	Lang, Charles H: 5 articles (07/2013 - 10/2004)
9.	Arcaro, Alexandre: 5 articles (03/2011 - 12/2006)
10.	Park, In-Chul: 4 articles (07/2015 - 03/2013)

Related Diseases

1.	Insulin Resistance 08/01/2008 - "Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats." 02/01/2007 - "Increased insulin resistance in 4E-BP1 and 4E-BP2 double KO mice was associated with increased ribosomal protein S6 kinase (S6K) activity and impairment of Akt signaling in muscle, liver, and adipose tissue. " 06/01/2006 - "Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1." 09/01/2005 - "Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability." 02/01/1993 - "Our results show that insulin resistance impairs signaling to the 70-kD S6 kinase."
2.	Fibrosis (Cirrhosis) 01/01/2011 - "Recent data highlight mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) signaling in tubulointerstitial fibrosis; however, the mechanisms remain unclear. " 05/07/2009 - "To investigate the relationship between 90-kuD ribosomal S6 kinase (p90RSK) and collagen type I expression during the development of hepatic fibrosis in vivo and in vitro. " 05/07/2009 - "Involvement of 90-kuD ribosomal S6 kinase in collagen type I expression in rat hepatic fibrosis." 10/01/2009 - "Recently, it was found that dithiolethione compounds had the activities to prevent or treat fibrosis, insulin resistance, and mitochondrial protective effects in the liver by a mechanism involving AMP-activated protein kinase (AMPK) and/or 70-kDa ribosomal protein S6 kinase 1 (S6K1). " 11/01/2006 - "Immunohistochemical study revealed that the expressions of both extracellular signal-regulated kinases (ERK) and ribosomal protein S6 kinase (RSK), two of the key genes in the MAPK pathway, were remarkably induced, which was closely correlated to that of collagen types I and III during the development of hepatic fibrosis. "
3.	Neoplasm Metastasis (Metastasis) 11/08/2013 - "The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis." 08/06/2007 - "The c-MET serves as an attractive therapeutic target in SCLC, as shown through small interfering RNA (siRNA) and selective prototype c-MET inhibitor SU11274, inhibiting the phosphorylation of c-MET itself and its downstream molecules such as AKT, S6 kinase, and ERK1/2. Investigation of mechanisms of invasion and, ultimately, metastasis in SCLC would be very useful with these signal transduction molecules." 10/15/2013 - "The ribosomal S6 kinase (RSK) family of kinases is a group of extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) effectors that can regulate these steps of metastasis by phosphorylating both nuclear and cytoplasmic targets. " 03/01/2007 - "Co-expression of EGF receptor, TGFalpha and S6 kinase is significantly associated with colorectal carcinomas with distant metastases at diagnosis."
4.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 02/01/2016 - "The ribosomal S6 kinase inhibitor BI-D1870 ameliorated experimental autoimmune encephalomyelitis in mice." 06/15/2013 - "Saquinavir-NO inhibits S6 kinase activity, impairs secretion of the encephalytogenic cytokines interleukin-17 and interferon-gamma and ameliorates experimental autoimmune encephalomyelitis."
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 08/01/2014 - "mTOR through its relationship with phosphoinositide 3-kinase (PI 3-K) and protein kinase B (Akt) and multiple downstream signaling pathways such as p70 ribosomal S6 kinase (p70S6K) and proline rich Akt substrate 40 kDa (PRAS40) promotes neuronal cell regeneration through stem cell renewal and oversees critical pathways such as apoptosis, autophagy, and necroptosis to foster protection against neurodegenerative disorders. "

Related Drugs and Biologics

1.	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)
2.	Proto-Oncogene Proteins c-akt (Protein Kinase B)
3.	Proline (L-Proline)
4.	AMP-Activated Protein Kinases
5.	Small Interfering RNA (siRNA)
6.	Cytokines
7.	Interleukin-17 (Interleukin 27)
8.	Saquinavir (Invirase)
9.	Interferon-gamma (Interferon, gamma)
10.	((3Z)- N- (3- chlorophenyl)- 3- ((3,5- dimethyl- 4- ((4- methylpiperazin- 1- yl)carbonyl)- 1H- pyrrol- 2- yl)methylene)- N- methyl- 2- oxo- 2,3- dihydro- 1H- indole- 5- sulfonamide)

Related Therapies and Procedures

1.	Nephrectomy
2.	Electroacupuncture
3.	Prostatectomy (Retropubic Prostatectomy)
4.	Hepatectomy
5.	Drug Therapy (Chemotherapy)