Gastrin-Releasing Peptide

Neuropeptide and gut hormone that helps regulate GASTRIC ACID secretion and motor function. Once released from nerves in the antrum of the STOMACH, the neuropeptide stimulates release of GASTRIN from the GASTRIN-SECRETING CELLS.

Also Known As:

Networked: 485 relevant articles (5 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Schally, Andrew V: 25 articles (05/2014 - 03/2002)
2.	Chung, Dai H: 15 articles (10/2013 - 05/2002)
3.	Schwartsmann, Gilberto: 14 articles (07/2014 - 02/2004)
4.	Qiao, Jingbo: 12 articles (10/2013 - 08/2004)
5.	Roesler, Rafael: 12 articles (01/2012 - 02/2004)
6.	Halmos, Gabor: 10 articles (02/2013 - 01/2005)
7.	Schally, A V: 10 articles (06/2005 - 03/2000)
8.	Benya, Richard V: 8 articles (02/2011 - 05/2002)
9.	Evers, B Mark: 8 articles (09/2008 - 05/2002)
10.	Block, Norman L: 7 articles (05/2014 - 01/2010)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2007 - "In a preliminary study, experimental CT-2A tumors were chronically treated with the small molecule 77427, a gastrin-releasing peptide (GRP) blocker compound that inhibits angiogenesis. " 03/01/2014 - "Gastrin-releasing peptide (GRP) acts as an important regulatory peptide in several normal physiological processes and as a growth factor in certain cancers. " 01/01/2014 - "Ann Lévesque obtained her PhD in Biochemistry at the Université Laval in Québec City in 1994 studying the biological actions of peptide analogs of the gastrin releasing peptide in the growth inhibition of cancer cells. " 11/14/2013 - "Tumor diagnosis with new 111In-radioligands based on truncated human gastrin releasing peptide sequences: synthesis and preclinical comparison." 10/01/2013 - "Gastrin-releasing peptide (GRP) is a neuroendocrine peptide shown to possess growth-stimulatory effects in many types of human cancers. "
2.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/01/1998 - "In a phase II trial, an antibody (2A11) directed against the autocrine growth factor gastrin-releasing peptide has been used to treat patients with relapsed small-cell lung cancer. " 01/01/1989 - "Initial monoclonal antibody therapy trials include an attempt to control malignant proliferation of small cell lung cancer by blocking the autocrine stimulation of gastrin releasing peptide. " 04/01/2006 - "Gastrin-releasing peptide (GRP) is a growth factor for small cell lung cancer (SCLC). " 05/15/2003 - "Gastrin-releasing peptide (GRP) is an autocrine growth factor in patients with small cell lung carcinoma (SCLC). " 07/01/1997 - "Small cell lung cancer (SCLC) cells express and secrete gastrin-releasing peptide (GRP) which binds to receptors and stimulates growth of these cells. "
3.	Colonic Neoplasms (Colon Cancer) 06/01/2006 - "Gastrin-releasing peptide (GRP) and its receptor (GRPR) are aberrantly up-regulated in colon cancer. " 09/01/2000 - "Gastrin-releasing peptide (GRP) is a mitogen and morphogen important in the development of human colon cancers. " 09/01/2000 - "Characterization of gastrin-releasing peptide and its receptor aberrantly expressed by human colon cancer cell lines." 07/01/2000 - "We herein demonstrate that the mitogen gastrin-releasing peptide (GRP) is a morphogen, critically important in regulating the differentiation of murine colon cancer. " 07/01/2000 - "Gastrin-releasing peptide is a mitogen and a morphogen in murine colon cancer."
4.	Mesothelioma 01/01/2006 - "This dark black area on the PET Scan image taken parallel to front and back of chest wall (with marked increase in asbestos, Gastrin-Releasing Peptide, & Osteopontine and marked decrease in glucose uptake in the pathological tissue) can be considered a characteristic finding for the diagnosis of mesothelioma." 01/01/2006 - "Reduced glucose uptake with markedly increased gastrin releasing peptide, osteopontine & asbestos found in dark black areas of PET Scan of chest wall in patient with mesothelioma."
5.	Amnesia (Dissociative Amnesia) 09/01/2001 - "We examined memory improvement with respect to the effects of gastrin-releasing peptide (GRP) in male C57BL/6J mice under conditions of experimentally induced amnesia. "

Related Drugs and Biologics

1.	Bombesin
2.	Hca(6)-Leu(13)-psi(CH2N)-Tac(14)- bombesin(6-14)
3.	Glucose (Dextrose)
4.	Cytotoxins
5.	Asbestos
6.	Peptides
7.	Gastrins
8.	Somatostatin (Somatotropin Release-Inhibiting Factor)
9.	Neuropeptides
10.	Substance P

Related Therapies and Procedures

1.	Radiotherapy
2.	Heterologous Transplantation (Xenotransplantation)
3.	Drug Therapy (Chemotherapy)
4.	Immunotherapy
5.	Intravenous Infusions