Proto-Oncogene Proteins c-met

Cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. They consist of an extracellular alpha chain which is disulfide-linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and sites critical for the regulation of kinase activity. Mutations of the gene for PROTO-ONCOGENE PROTEINS C-MET are associated with papillary renal carcinoma and other neoplasia.

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Networked: 353 relevant articles (2 outcomes, 43 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nakamura, Toshikazu: 12 articles (10/2010 - 05/2003)
2.	Matsumoto, Kunio: 9 articles (07/2013 - 05/2003)
3.	Comoglio, Paolo M: 7 articles (12/2014 - 08/2003)
4.	Safe, Stephen: 5 articles (02/2014 - 07/2009)
5.	Nakamura, T: 5 articles (11/2001 - 12/2000)
6.	Prat, Maria: 4 articles (02/2015 - 02/2003)
7.	Matsumoto, K: 4 articles (10/2001 - 12/2000)
8.	Jiang, Wen G: 3 articles (01/2015 - 01/2004)
9.	Zimmer, Yitzhak: 3 articles (09/2014 - 11/2003)
10.	Liu, Youhua: 3 articles (09/2013 - 01/2005)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2014 - "Several therapeutic strategies for inhibiting activated hepatocyte growth factor receptor (HGFR) and the subsequent downstream signaling transduction have been improved in order to block tumor growth. " 02/01/2012 - "Recent studies suggest a potential link between DNA repair and aberrant activation of the hepatocyte growth factor receptor Mesenchymal-Epithelial Transition (MET), an oncogene that is overexpressed in numerous types of human tumors and considered a prime target in clinical oncology. " 03/15/2003 - "Immunochemical studies of c-met expression in BALF cytospin preparations and tumor sections showed that most HGF receptor-bearing cells were tumor cells. " 03/01/2000 - "In the present study, 102 benign and malignant human musculoskeletal tumors were examined for expression of the HGF receptor by Western blotting and/or immunohistochemistry. " 10/01/1996 - "In this study, we analyzed the expression of Met/HGF receptor by Western blotting and immunohistochemistry in frozen samples of 87 primary tumors of bone and soft tissues. "
2.	Herpes Simplex 08/15/2007 - "In the present study, we revealed that the extent of endogenous HGF up-regulation was less than that of c-Met, an HGF receptor, during the acute phase of SCI and administered exogenous HGF into injured spinal cord using a replication-incompetent herpes simplex virous-1 (HSV-1) vector to determine whether HGF exerts beneficial effects and promotes functional recovery after SCI. This treatment resulted in the significant promotion of neuron and oligodendrocyte survival, angiogenesis, axonal regrowth, and functional recovery after SCI. These results suggest that HGF gene delivery to the injured spinal cord exerts multiple beneficial effects and enhances endogenous repair after SCI. This is the first study to demonstrate the efficacy of HGF for SCI."
3.	Neoplasm Metastasis (Metastasis) 08/01/2010 - "Met, the hepatocyte growth factor receptor, is important in transducing signals for tumour growth and metastasis. " 04/01/2009 - "Expression of pY1349 hepatocyte growth factor receptor/c-Met was a marker of metastasis and (P = .001) and cause-specific survival (P = .003). " 11/01/2012 - "Emerging evidence indicates that hepatocyte growth factor receptor (or Met) pathway plays a pivotal role in HNSCC metastasis and resistance to chemotherapy. " 07/01/2012 - "The aim of this study is to explore the expressions of MACC1 and hepatocyte growth factor receptor (c-met), and its relationship with invasion, metastasis, and prognosis of non-small cell lung cancer (NSCLC). " 01/01/2000 - "Experimental and clinicopathologic studies on the function of the HGF receptor in human colon cancer metastasis."
4.	Carcinoma (Carcinomatosis) 02/01/2003 - "The purpose of this study is to evaluate the significance of the c-Met/hepatocyte growth factor receptor expression in invasive cervical carcinoma. " 06/01/2009 - "Nuclear localization of active HGF receptor Met in aggressive MDA-MB231 breast carcinoma cells." 04/01/2007 - "Using Lentiviral vectors carrying the HGF transgene, we transduced SK-OV-3 and NIH:OVCAR-3 ovarian carcinoma cell lines to obtain stable autocrine and paracrine HGF receptor activation. " 02/01/2003 - "Overexpression of the c-Met/HGF receptor and its prognostic significance in uterine cervix carcinomas." 02/01/2002 - "High expression of Met/hepatocyte growth factor receptor suppresses tumorigenicity in NCI-H1264 lung carcinoma cells."
5.	Hepatocellular Carcinoma (Hepatoma) 01/01/2003 - "Furthermore, 8/9 fibrolamellar hepatocellular carcinomas demonstrated hepatocyte growth factor receptor levels similar to normal, whereas 8/9 hepatocellular carcinomas and 11/12 cirrhotic livers exhibited either an increase or decrease. " 01/01/1999 - "Hepatocellular carcinoma (HCC) often metastasizes, and the c-Met/HGF receptor is highly expressed by HCC cells. " 07/01/2005 - "Both types of hepatomas were revealed to have higher adenoviral gene transduction efficiencies and more efficient expressions of the HGF transgene, which successfully activated the HGF receptor/c-Met in an autocrine fashion, than those of other types of cancer. " 04/01/2015 - "The present study investigated and comparatively analyzed the opposing effects exerted by GM3 on the migration of mouse hepatocellular carcinoma Hepa1‑6 cells via epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (HGFR/cMet). " 12/01/2010 - "The two-chain form of HGF exhibited biological activity, assessed by phosphorylation of the HGF receptor (c-Met) and extracellular signal-regulated kinase, and scattered morphology in human hepatocellular carcinoma cell line HepG2. "

Related Drugs and Biologics

1.	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)
2.	Epidermal Growth Factor Receptor (EGF Receptor)
3.	Phosphotransferases (Kinase)
4.	Tyrosine (L-Tyrosine)
5.	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
6.	Proto-Oncogene Proteins c-met
7.	Epidermal Growth Factor (EGF)
8.	Carbon Monoxide
9.	Intercellular Signaling Peptides and Proteins (Growth Factors)
10.	Protein-Tyrosine Kinases (Tyrosine Kinase)

Related Therapies and Procedures

1.	Ligation
2.	Gastrectomy
3.	Heterologous Transplantation (Xenotransplantation)
4.	Transplantation (Transplant Recipients)
5.	Therapeutics