Ethanolamine (Colamine)

A viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. It is used as a surfactant, fluorimetric reagent, and to remove CO2 and H2S from natural gas and other gases.

Also Known As:

Networked: 355 relevant articles (5 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cravatt, Benjamin F: 3 articles (01/2009 - 06/2004)
2.	Torchilin, Vladimir P: 3 articles (09/2008 - 01/2004)
3.	Calignano, Antonio: 3 articles (07/2008 - 01/2005)
4.	Piomelli, Daniele: 3 articles (07/2008 - 01/2005)
5.	Mohammad, Innus: 2 articles (12/2015 - 06/2013)
6.	Zanganeh, Saeid: 2 articles (12/2015 - 06/2013)
7.	Smith, Michael B: 2 articles (12/2015 - 06/2013)
8.	Zhu, Quing: 2 articles (12/2015 - 06/2013)
9.	Boor, Paul J: 2 articles (12/2015 - 12/2014)
10.	Xu, Ya: 2 articles (12/2015 - 12/2014)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2013 - "In vivo mouse tumor imaging studies were completed and demonstrate an improved imaging capability of the new dye relative to an earlier version of the dye that was synthesized with an ethanolamine linker (ethanolamine-2-nitroimidazole-ICG). " 07/01/2008 - "PC was significantly higher (0.39 +/- 0.40 mmol/kg vs. 0.02 +/- 0.07 mmol/kg, z = 3.5), while ethanolamine (Eth) was significantly lower in cancer versus benign prostate tissues (1.0 +/- 0.8 mmol/kg vs. 2.3 +/- 1.9 mmol/kg, z = 3.3). " 01/01/1994 - "We are now presenting the pharmacokinetics, in vivo metabolism and distribution of a [14C]PNAE(s) preparation (1-O-octadecyl-2-oleoyl-sn-glycero-3-phospho-(N-[U-14C]palmitoyl) ethanolamine in the intact or Mc11-tumor-bearing BDF1 mice. " 01/01/1993 - "The macrophage activator muramyl tripeptide-phosphatidyl ethanolamine (MTP-PE) was infused in liposomal form in 14 metastatic cancer patients (4 mg i.v. during 30 min twice weekly for 12 weeks). " 09/01/1988 - "Mammary tumor cells which retain properties of the normal tissue are also likely to be ethanolamine responsive, whereas dedifferentiated, highly tumorigenic mammary tumor cells are ethanolamine nonresponsive. "
2.	Osteosarcoma (Osteogenic Sarcoma) 06/01/2006 - "Liposomal muramyl tripeptide phosphatidyl ethanolamine (L-MTP-PE) is a synthetic biological investigational agent used for treating osteosarcoma. " 02/01/2008 - "Liposomal muramyl tripeptide phosphatidyl ethanolamine (L-MTP-PE) is a new agent that improves overall osteosarcoma survival (chemotherapy without L-MTP-PE 70% versus with L-MTP-PE 78%; p = 0.03). " 02/01/2008 - "Liposomal muramyl tripeptide phosphatidyl ethanolamine: a safe and effective agent against osteosarcoma pulmonary metastases." 01/01/2014 - "Muramyl tripeptide-phosphatidyl ethanolamine encapsulated in liposomes (L-MTP-PE) in the treatment of osteosarcoma." 05/01/2010 - "Mifamurtide, also known as liposomal muramyl tripeptide phosphatidyl ethanolamine (L-MTP-PE), has been approved for the treatment of osteosarcoma in Europe. "
3.	Neoplasm Metastasis (Metastasis) 02/01/2008 - "Liposomal muramyl tripeptide phosphatidyl ethanolamine: a safe and effective agent against osteosarcoma pulmonary metastases." 01/01/2009 - "These data indicate that nylon net filters coated with ethanolamine groups are able to trap Colo201 cells at a higher specificity than unmodified nylon net filters, effectively isolating and removing them from the blood, and suggest the potential benefits of the prevention of metastasis, cancer assessment and examination technologies as essential pre-treatment strategies." 01/01/2008 - "Analyses of fatty acyl chains from ethanolamine-containing plasmalogens provided a reliable tumor marker that correlated with high Se and linearity with metastases spreading. " 03/03/1988 - "Metastases from cells cultured with serum, choline or dimethylethanolamine, but not from monomethylethanolamine or ethanolamine, were extensive and highly invasive. " 03/03/1988 - "Serum and choline-fed cells most frequently metastasized (74% and 68%, respectively), while frequency of lung metastasis was 46%, 42% and 17% in mice injected with cells fed with dimethylethanolamine, monomethylethanolamine, and ethanolamine, respectively. "
4.	Anoxia (Hypoxia) 12/15/1976 - "Total plasmalogens and O-(acylalkylglycerophosphoryl) ethanolamine from labelled hexadecanol and palmitate during hypoxia and anoxia in rat heart." 12/14/2015 - "We previously reported that linking 2-nitroimidazole to an indocyanine dicarboxylic acid dye derivative () using an ethanolamine linker (ethanolamine-2-nitroimidazole-ICG, ), led to a dye-conjugate that gave promising results for targeting cancer hypoxia in vivo. " 03/01/1985 - "A rise in the n-6/n-3 ratio, for ethanolamine glycerophosphatides and phosphatidyl choline, occurred when the oxygen concentration was increased (hypoxia to hyperoxia). " 08/01/2004 - "We determined the following: (a) 4-HPR cytotoxicity against 12 ESFT cell lines in vitro; (b) whether 4-HPR increased ceramide species (saturated and desaturated ceramides); (c) whether physiological hypoxia (2% O(2)) affected cytotoxicity, mitochondrial membrane potential (DeltaPsi(m)) change, or ceramide species or reactive oxygen species levels; (d) whether cytotoxicity was enhanced by l-threo-dihydrosphingosine (safingol); (e) whether physiological hypoxia increased acid ceramidase (AC) expression; and (f) the effect of the AC inhibitor N-oleoyl-ethanolamine (NOE) on cytotoxicity and ceramide species. " 04/01/1995 - "Ten minutes of hypoxia did not cause a significant change in the total phospholipid mass of ethanolamine or choline phospholipids; however, phosphate analysis of the individual phospholipid molecular species containing esterified arachidonic acid in isolated proximal tubules demonstrated a 24% reduction in the mass of the plasmenylethanolamine molecular species with the vinyl ether of oleylaldehyde at the sn-1 position and a 35% reduction in the mass of plasmenylcholine species with palmitaldehyde at the sn-1 position. "
5.	Autolysis 02/01/1983 - "pneumoniae that were rendered resistant to autolysis by growth in ethanolamine. " 01/01/1985 - "Autolysis-resistant type 14 pneumococci were obtained by substituting ethanolamine for choline in a defined culture medium. " 01/01/1968 - "Biological consequences of the replacement of choline by ethanolamine in the cell wall of Pneumococcus: chanin formation, loss of transformability, and loss of autolysis." 04/16/1996 - "Phosphatidyl inositol, phosphatidyl choline, phosphatidyl glycerol, phosphatidyl serine, phosphatidyl ethanolamine, phosphatidic acid and sphingomyelin were all found to be effective at reducing the Ca2+ requirement for m-calpain autolysis. "

Related Drugs and Biologics

1.	Choline (Choline Chloride)
2.	Serine (L-Serine)
3.	Phosphatidylinositols (Phosphatidylinositol)
4.	Phosphatidic Acids (Phosphatidic Acid)
5.	polidocanol (Laureth)
6.	Phosphatidylglycerols
7.	m-calpain
8.	azomycin
9.	Phospholipids
10.	Niclosamide

Related Therapies and Procedures

1.	Sclerotherapy
2.	Drug Therapy (Chemotherapy)
3.	Lenses
4.	Injections
5.	Neurosurgical Procedures