Ethanolamine (Colamine)

A viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. It is used as a surfactant, fluorimetric reagent, and to remove CO2 and H2S from natural gas and other gases.

Also Known As:

Networked: 524 relevant articles (12 outcomes, 40 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Han, Pengxun: 5 articles (03/2022 - 01/2018)
2.	Shao, Mumin: 5 articles (03/2022 - 01/2018)
3.	Sun, Huili: 5 articles (03/2022 - 01/2018)
4.	Yu, Xuewen: 5 articles (03/2022 - 01/2018)
5.	Kendall, Melissa M: 5 articles (01/2020 - 11/2015)
6.	Weng, Wenci: 4 articles (03/2022 - 01/2019)
7.	Miyazawa, Teruo: 4 articles (11/2021 - 02/2016)
8.	Nakagawa, Kiyotaka: 4 articles (11/2021 - 02/2016)
9.	Yamashita, Shinji: 4 articles (11/2021 - 02/2016)
10.	Di Marzo, Vincenzo: 4 articles (01/2021 - 03/2005)

Related Diseases

1.	Neoplasms (Cancer) 12/11/2017 - "The 3H) ethanolamine, and a biodistribution study was carried out in nude mice bearing HT1080 tumor xenografts 48 h after intravenous delivery. " 01/01/2023 - "Reduced plasma phosphatidyl ethanolamine level is detected in mice lack of cancer-derived miR-204-5p secretion in vivo. " 12/20/2021 - "Compounds 12 and 13 substituted with ethanolamine and propargyl groups reveal potent cytotoxicity towards A549 cancer cells with IC50 values of 140 and 310 nM, respectively. " 06/07/2016 - "In addition, eutC, a gene belonging to the ethanolamine metabolic pathway, also confers an advantage for Salmonella within tumors, perhaps by exploiting either ethanolamine or an alternative nutrient in the inflamed tumor environment. " 07/01/2008 - "PC was significantly higher (0.39 +/- 0.40 mmol/kg vs. 0.02 +/- 0.07 mmol/kg, z = 3.5), while ethanolamine (Eth) was significantly lower in cancer versus benign prostate tissues (1.0 +/- 0.8 mmol/kg vs. 2.3 +/- 1.9 mmol/kg, z = 3.3). "
2.	Obesity 09/01/2011 - "[Clinical effectiveness of N-oleyl-phosphatidyl-ethanolamine (NOPE) in obesity: our experience]." 10/01/2023 - "Obesity promotes a leaky gut, inflammation and pre-diabetes by lowering gut microbiota that metabolise ethanolamine." 02/01/2019 - "Recently, niclosamide ethanolamine salt (NEN) was found to be a safe and effective hepatic mitochondrial uncoupler for the prevention and treatment of obesity and T2D in mouse models. " 10/31/2021 - "Age-related macular degeneration (AMD) is central vision loss with aging, was the fourth main cause of blindness in 2015, and has many risk factors, such as cataract surgery, cigarette smoking, family history, hypertension, obesity, long-term smart device usage, etc. AMD is classified into three categories: normal AMD, early AMD, and late AMD, based on angiogenesis in the retina, and can be determined by bis-retinoid N-retinyl-N-retinylidene ethanolamine (A2E)-epoxides from the reaction of A2E and blue light. " 01/01/2018 - "Niclosamide and its salt forms, Niclosamide Ethanolamine (NEN), and Niclosamide Piperazine (NPP) have shown efficacy in murine models of diet induced obesity characterized by attenuation of the prominent fatty liver disease phenotype and improved glucose metabolism. "
3.	Inflammation (Inflammations) 05/01/2019 - "coli metabolism of ethanolamine seen in the intestine during active CD, and its decrease during remission, indicates ethanolamine use may be a key factor in shaping the intestinal microbiome in CD patients, particularly during times of inflammation. " 05/01/2019 - "Intestinal ethanolamine is however readily accessible during periods of intestinal inflammation, and enables pathogens to outcompete the host microbiota under such circumstances. " 01/01/2019 - "faecalis isolated from monoassociated wild type and IL-10-/- mice identified 408 genes including 14 genes of the ethanolamine utilization (eut) locus that were significantly up-regulated in response to inflammation. " 10/18/2011 - "Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota." 04/01/1989 - "Only 5% ethanolamine produced inflammation consistently confined to the mucosa and submucosa. "
4.	Osteosarcoma (Osteogenic Sarcoma) 09/01/2017 - "Although primary and metastatic osteosarcomas are infiltrated with M2 macrophages, targeting the M1 macrophages with the immune adjuvant muramyl tripeptide phosphatidyl ethanolamine (MTP-PE) has been the greatest recent therapeutic advance in osteosarcoma. " 06/01/2006 - "Liposomal muramyl tripeptide phosphatidyl ethanolamine (L-MTP-PE) is a synthetic biological investigational agent used for treating osteosarcoma. " 02/01/2008 - "Liposomal muramyl tripeptide phosphatidyl ethanolamine (L-MTP-PE) is a new agent that improves overall osteosarcoma survival (chemotherapy without L-MTP-PE 70% versus with L-MTP-PE 78%; p = 0.03). " 02/01/2008 - "Liposomal muramyl tripeptide phosphatidyl ethanolamine: a safe and effective agent against osteosarcoma pulmonary metastases." 01/01/2020 - "Muramyl tripeptide-phosphatidyl ethanolamine encapsulated in liposomes (L-MTP-PE) was derived as a compound with the ability to stimulate macrophages to destroy autologous osteosarcoma tumor cells. "
5.	Varicose Veins (Varicose Vein) 08/01/1988 - "We conclude that ethanolamine seems to be safer and more efficacious than STD for sclerosing oesophageal varices." 07/01/2023 - "Trans-catheter ethanolamine foam embolization is an effective and safe method to treat pelvic and atypical lower limb varices." 11/06/2015 - "Injection sclerotherapy with ethanolamine was performed and the patient experienced a favorable outcome with near resolution of his varices on endoscopic follow-up. " 07/01/1994 - "Sclerotherapy was performed by intravariceal injection of 5% ethanolamine at days 0, 4 10, 30 and then monthly until eradication of varices. " 04/01/1951 - "[Death during sclerosing treatment of varices with oleate of mono-ethanolamine]."

Related Drugs and Biologics

1.	Niclosamide
2.	Salts
3.	Coloring Agents (Dyes)
4.	Phosphatidylcholines (Phosphatidylcholine)
5.	Phosphatidylinositols (Phosphatidylinositol)
6.	Acids
7.	Polidocanol (Laureth)
8.	Doxorubicin (Adriamycin)
9.	1,2-distearoylphosphatidylethanolamine (DSPE)
10.	Phosphatidylserines

Related Therapies and Procedures

1.	Catheters
2.	Therapeutics
3.	Combined Modality Therapy
4.	Sclerotherapy
5.	Drug Therapy (Chemotherapy)