Heptanol (1 Heptanol)

05/01/2014 - "In conclusion, heptanol significantly decreased the incidence of VT and VF induced by regional ischemia and prolonged the PR interval, QT interval and MAPD90. "
01/01/2005 - "The aims of the present study were to examine the effect of heptanol on electrical coupling during ischemia, and to assess whether changes in electrical coupling by heptanol is associated with its cardiac protection. "
01/01/2005 - "These results demonstrate that treatment with the gap junction uncoupler heptanol confers cardioprotection against ischemia, and this effect is related to delayed electrical uncoupling during prolonged ischemia."
01/01/2005 - "In the prolonged ischemia model, heptanol delayed the onset of uncoupling, increased time to plateau, and decreased the maximal rate of uncoupling during ischemia. "
01/01/2005 - "Perfused isolated rat hearts were subjected to a 24 min infusion of heptanol (0.05, 0.1, 0.5 or 1.0 mmol/L) followed by 70 min of global no-flow ischemia or by 20 min of regional ischemia and 60 min of reperfusion. "

03/01/2008 - "For the in vivo experiments, the potential therapeutic efficacy of heptanol and carbenoxolone was surveyed after it was given intravenously in the rabbit double-hemorrhage model. "
03/01/2008 - "For the in vivo method, heptanol and carbenoxolone significantly decreased the narrowing of BAs when given intravenously in the rabbit double-hemorrhage model. "

11/02/2010 - "In wound healing studies, circular, 6-mm diameter corneal wounds were produced in the central CE using the n-heptanol technique. "
10/01/2023 - "Wound healing was studied using a scratch assay in LEC or 1-heptanol wounds in organ-cultured corneas. "
12/01/2016 - "For in vivo experiments, we applied n-heptanol on the cornea of GPx4+/+ and GPx4+/- mice to create corneal epithelial wound. "
01/01/2015 - "New Zealand rabbits were anaesthetised and wounds were made by placing Whatman paper discs soaked in n-heptanol on the cornea. "
12/17/2013 - "Ten days after transfection, 5-mm epithelial wounds were made with n-heptanol and healing time recorded. "

08/01/2005 - "The aims of the present study were to examine the effect of heptanol on infarct size, arrhythmias and myocardial tissue resistance and to assess whether changes in electrical coupling correlate with cardiac protection. "
06/01/2019 - "The infarction size, heart function, and mortality were totally or partially restored in the S1P2, S1P3 agonist-pretreated IR group, and the heptanol/Gap26-treated S1P2/3-blocked IR group. "
04/01/2011 - "To investigate mechanisms behind heptanol (Hp)-induced infarct size reduction and in particular if protection by pre-treatment with Hp is triggered through mitochondrial mechanisms. "
08/15/2004 - "Transient inhibition of gap junction (GJ)-mediated communication with heptanol during myocardial reperfusion limits infarct size. "
05/01/2002 - "To test the converse corollary, we assessed the effect of heptanol-an agent well recognized to rapidly and reversibly uncouple gap junctions--on the reduction of infarct size (delineated by tetrazolium staining) achieved with PC. "

03/01/1983 - "Specular microscopy was used to study the morphologic appearance of normal and regenerating rabbit corneal epithelium before and after corneal abrasion or heptanol application. "
08/01/1998 - "A corneal abrasion with a diameter of 6 mm was created centrally in both eyes with a trephine and subsequent rubbing off of the corneal epithelium with an n-heptanol soaked swab The corneal abrasions were treated twice daily with topical applications (50 microl); RA was placed in the right inferior fornix and its vaseline vehicle in the left inferior fornix. "
01/01/1998 - "Effect of topical Na-hyaluronan on hemidesmosome formation in n-heptanol-induced corneal injury."