A tetrameric calcium release channel in the SARCOPLASMIC RETICULUM membrane of SMOOTH MUSCLE CELLS, acting oppositely to SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. It is important in skeletal and cardiac excitation-contraction coupling and studied by using RYANODINE. Abnormalities are implicated in CARDIAC ARRHYTHMIAS and MUSCULAR DISEASES.
Also Known As:
Ryanodine Receptor; Ca Release Channel-Ryanodine Receptor; Receptor, Ryanodine; RyR2; RyR3; Ca Release Channel Ryanodine Receptor; Calcium Ryanodine Receptor Complex; Complex, Calcium-Ryanodine Receptor; Receptor 1, Ryanodine; Receptor 2, Ryanodine; Receptor 3, Ryanodine; Receptor Complex, Calcium-Ryanodine; Receptors, Ryanodine; Calcium-Ryanodine Receptor Complex; RyR1; Ryanodine Receptor 1; Ryanodine Receptor 2; Ryanodine Receptor 3; Ryanodine Receptors