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Sodium-Calcium Exchanger

Subscribe to New Research on Sodium-Calcium Exchanger

An electrogenic ion exchange protein that maintains a steady level of calcium by removing an amount of calcium equal to that which enters the cells. It is widely distributed in most excitable membranes, including the brain and heart.

Also Known As:

Ca(2+)-Na(+) Antiporter; Calcium-Sodium Antiporter; Na(+)-Ca(2+) Antiporter; Sodium-Calcium Antiporter; Antiporter, Calcium-Sodium; Antiporter, Sodium-Calcium; Calcium Sodium Antiporter; Calcium Sodium Carrier; Calcium Sodium Exchanger; Carrier, Calcium-Sodium; Carrier, Sodium-Calcium; Exchanger, Calcium-Sodium; Exchanger, Sodium-Calcium; Sodium Calcium Antiporter; Sodium Calcium Carrier; Sodium Calcium Exchanger; Ca(2+)-Na(+) Exchanger; Calcium-Sodium Carrier; Calcium-Sodium Exchanger; Na(+)-Ca(2+) Exchanger; Sodium-Calcium Carrier

Networked: 195 relevant articles (3 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Carrier Proteins: 11456
    - Membrane Transport Proteins: 165
      - Ion Pumps: 30
        Antiporters: 21
        Sodium-Calcium Exchanger: 195
        sodium-calcium exchanger 1: 12
        potassium-dependent sodium-calcium exchanger: 3
        human SLC24A3 protein
        human SLC24A6 protein
        human SLC38A3 protein
        mouse NCX1 protein
        mouse Slc24a3 protein
        mouse Slc8a2 protein
        mouse Slc8a3 protein
        rat NCX10 protein
        rat Slc24a3 protein
        rat Slc8a2 protein
        rat Slc8a3 protein
  - Membrane Proteins: 5300
    - Membrane Transport Proteins: 165
      - Ion Pumps: 30
        Antiporters: 21
        Sodium-Calcium Exchanger: 195
        sodium-calcium exchanger 1: 12
        potassium-dependent sodium-calcium exchanger: 3
        human SLC24A3 protein
        human SLC24A6 protein
        human SLC38A3 protein
        mouse NCX1 protein
        mouse Slc24a3 protein
        mouse Slc8a2 protein
        mouse Slc8a3 protein
        rat NCX10 protein
        rat Slc24a3 protein
        rat Slc8a2 protein
        rat Slc8a3 protein

Experts

1.	Annunziato, Lucio: 12 articles (08/2015 - 11/2004)
2.	Di Renzo, Gianfranco: 10 articles (08/2015 - 11/2004)
3.	Pignataro, Giuseppe: 9 articles (08/2015 - 11/2004)
4.	Sirabella, Rossana: 8 articles (05/2015 - 11/2004)
5.	Boscia, Francesca: 7 articles (08/2015 - 04/2006)
6.	Matsuda, Toshio: 6 articles (09/2015 - 01/2003)
7.	Cuomo, Ornella: 6 articles (08/2015 - 11/2004)
8.	Philipson, Kenneth D: 6 articles (06/2014 - 11/2002)
9.	Scorziello, Antonella: 5 articles (08/2015 - 03/2009)
10.	Iwamoto, Takahiro: 5 articles (01/2015 - 08/2002)

Related Diseases

1.	Reperfusion Injury 03/01/2008 - "[Role of sodium-calcium exchanger in the myocardial protection against ischemia-reperfusion injury]." 03/01/2008 - "The effect of acidic perfusion on reperfusion injury was studied in isolated rat hearts submitted to 40 min of ischaemia and 30 min of reperfusion, and its effect on the Na(+)/Ca(2+)-exchanger (NCX) was analysed in isolated myocytes. " 02/13/2004 - "We used Na(+)-Ca(2+) exchanger (NCX) knockout mice to evaluate the effects of NCX in cardiac function and the infarct size after ischemia/reperfusion injury. " 03/01/2008 - "Present study was aimed at investigation into the role of sodium-calcium exchanger (NCX) in myocardial ischemia-reperfusion injury and ischemic preconditioning (IPC). " 01/01/2003 - "The Na(+)/Ca(2+) exchanger (NCX) is involved in myocardial ischemia-reperfusion injuries. "
2.	Hypertension (High Blood Pressure) 12/01/2007 - "Two recent developments may now allow a more careful consideration of this: first, the greatly improved understanding of the role of salt in hypertension (particularly the identification of subgroups of salt-sensitive individuals within the general population), and second, the recent discovery of the role of the Na(+)/Ca(2+) exchanger in smooth muscle function. " 09/01/2006 - "Our recent studies using selective Na(+)/Ca(2+) exchange inhibitors and genetically engineered mice provide compelling evidence that salt-dependent hypertension is triggered by Ca(2+) entry through Na(+)/Ca(2+) exchanger type 1 (NCX1) in arterial smooth muscle. " 11/01/2005 - "Recent studies using selective Na(+)/Ca(2+) exchanger (NCX) inhibitors and genetically engineered mice provide compelling evidence that salt-sensitive hypertension is triggered by Ca(2+) entry through NCX type 1 (NCX1) in arterial smooth muscle. " 10/01/2006 - "The reverse-mode of the Na(+)/Ca(2+)-exchanger (NCX) mediates Ca(2+)-entry in agonist-stimulated vascular smooth muscle (VSM) and plays a central role in salt-sensitive hypertension. " 01/15/2007 - "Altered Na(+)-Ca(2+) exchanger (NCX) activity has been implicated in arrhythmias, hypertension and heart failure and may be a target for PUFA. "
3.	Acute Necrotizing Pancreatitis 05/01/2012 - "This study aims to investigate the relationship between the protective effects of melatonin in pancreas and the expression of sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) and Na(+)/Ca(2+) exchanger (NCX) in rats with acute necrotizing pancreatitis (ANP), to verify whether melatonin ameliorates ANP by alleviating calcium overload. "
4.	Ischemia 03/01/2007 - "Over the last few years, although extensive studies have focused on the relevant function played by the sodium-calcium exchanger (NCX) during focal ischemia, a thorough understanding of its role still remains a controversial issue. " 06/01/2013 - "Reverse-mode activation of the Na(+)/Ca(2+) exchanger (NCX) during reperfusion following ischemia contributes to Ca(2+) overload and cardiomyocyte injury. " 03/01/2009 - "The function of the Na(+)/Ca(2+) exchanger is affected by AP waveform and ion concentrations; its major role is Ca(2+) extrusion, but under pathological conditions such as ischemia-reperfusion, it allows Ca(2+) influx and leads to myocardial injury, including loss of mitochondrial function. " 08/01/2008 - "In addition, NHE inhibitor treatment blocked Na(+)/Ca(2+) exchanger 1 immunoreactivity in the CA1 region after transient forebrain ischemia. " 05/01/2006 - "Alterations of immunoreactivity and protein contents of Na(+)/Ca(2+) exchanger 1 (NCX1) were observed in the gerbil hippocampus proper after 5 min of transient forebrain ischemia. "
5.	Anoxia (Hypoxia) 06/01/2014 - "Low extracellular Na(+) concentration enhanced the hypoxia-induced increase of (Ca(2+))i. These results suggest that hypoxia-induced Ca(2+) increase in fetal SPASMC results from cytosolic Ca(2+) influx mediated primarily by the reverse mode of Na(+)/Ca(2+) exchanger." 04/27/2012 - "To investigate its mechanisms, we characterized the effects of F(2) on Na(+)/Ca(2+) exchanger currents (I(NCX)) and the L-type Ca(2+) channel current (I(Ca,L)) of cardiomyocytes during either hypoxia/reoxygenation or exposure to H(2)O(2). " 06/01/2011 - "Up to now a little is known about the effect of hypoxia on the sodium calcium exchanger type 1 (NCX1) expression and function. " 06/01/2011 - "Chemically mimicked hypoxia modulates gene expression and protein levels of the sodium calcium exchanger in HEK 293 cell line via HIF-1α." 10/01/2007 - "It has been proposed that a hypoxia-induced inhibition of the Na(+)-Ca(2+) exchanger (NCX) contributes to hypoxic pulmonary vasoconstriction (HPV). "

Related Drugs and Biologics

1.	Calcium
2.	Adenosine Triphosphatases (ATPase)
3.	Atrial Natriuretic Factor (ANF)
4.	Melatonin
5.	Sodium-Hydrogen Antiporter
6.	Sodium
7.	phospholamban
8.	Protein Isoforms (Isoforms)
9.	Proteins (Proteins, Gene)
10.	Calsequestrin