Cholic Acid

02/01/1980 - "Plasma clearance of oral and intravenous cholic acid in subjects with and without chronic liver disease."
09/01/1977 - "This study raises the possibility that the clinical liver disease seen in patients with a metabolic block in the conversion of THCA into cholic acid may be caused by tauro-THCA."
01/01/2021 - "Due to the systemic impacts of hepatic damage, Cholbam should be initiated in patients without signs of advanced liver disease."
03/01/1991 - "[Cholic acid levels in the serum of dairy cows with metabolically-caused liver diseases]."
01/01/1985 - "In general, an increased serum level of cholic acid indicated more serious liver disease. "

01/01/2021 - "To induce cholestasis, Atp8b1 mutant mice received a diet containing 0.1% cholic acid (CA) and WT mice were treated with ANIT. "
02/05/2020 - "Meanwhile, the results of contents variation of BAs in liver and serum showed that both hydrophilic and hydrophobic BAs were markedly increased in the model rats, while XYLDF treatment could restore the increase induced by ANIT, which suggested that one of the mechanisms of XYLDF on cholestasis referred to regulation of metabolic homeostasis of cholic acid."
01/01/2019 - "Cholestasis was induced in male C57BL/6 mice with a 0.5% cholic acid (CA)-supplemented diet for 10 weeks prior to mating with normal chow (NC)-fed females. "
11/01/2018 - "Some mice were placed on a 1% cholic acid (CA) diet to induce cholestasis or on a control diet. "
06/01/2007 - "Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis."

06/01/2023 - "The stool cholic acid (p = 0.001) level was significantly increased in NAFLD patients. "
11/04/2019 - "Reducing cholic acid synthesis may be a potential therapeutic strategy to treat dyslipidemia and nonalcoholic fatty liver disease."
11/01/2017 - "Cholic Acid Enhances Visceral Adiposity, Atherosclerosis and Nonalcoholic Fatty Liver Disease in Microminipigs."
10/06/2023 - "Liver tissue from wild-type C57BL/6 mice fed with a high-fat diet containing cholesterol and cholic acid for 4-12 weeks was used to examine galectin-12 expression and its correlation with nonalcoholic fatty liver disease. "
05/12/2023 - "After being treated with NKK20, the concentrations of cholic acid, glycinocholic acid, and glycinodeoxycholic acid in livers of the NAFLD mice were significantly decreased, while the concentration of aminodeoxycholic acid was significantly increased. "

08/01/1973 - "Factors affecting plasma clearance of (14C) cholic acid in patients with cirrhosis."
11/01/1973 - "Patients with mild cirrhosis also had significantly reduced cholic acid synthesis (average 152 mg per day) but they all were well and alive three to 23 months after the study. "
11/01/1973 - "Nine of the 10 patients with advanced cirrhosis and a very low cholic acid synthetic rate (average 68 mg per day) died within one to 13 months from the start of the study. "
11/01/2019 - "It is noted that the SD rats fed an HFC diet supplemented with 2% (w/w) cholic acid for 18 weeks frequently developed advanced fibrosis, including cirrhosis. "
10/01/1983 - "In 12 patients with Laennec's cirrhosis conjugated cholic acid was measured by radioimmunoassay simultaneously in the portal vein, the aorta, and the hepatic vein. "

07/01/1978 - "In further experiments it could be shown that ascites hepatoma cells were unable to conjugate cholic acid. "
02/07/2023 - "The novel nanoliposome modified by cholic acid may help to expand the application of irinotecan hydrochloride in the treatment of hepatocellular carcinoma and construct the drug delivery system mode of drug liver targeting."
01/01/2016 - "Synthesis of cholic-acid-carrying polymer and in-vitro evaluation of hepatoma-targeting nanoparticles decorated with the polymer."
02/11/2000 - "HPLC analysis of bile samples collected for 1 h at different time points during hepatocarcinogenesis revealed that in contrast to what happens during cholestatic disease, a continuous and progressive increase in the cholic acid-to-chenodeoxycholic acid ratio (from 4.4+/-0.5 in control animals to 15.1+/-1.9 in rats with hepatocellular carcinoma) occurs. "
07/01/1978 - "The uptake of cholic acid as well as taurocholic acid into AS-30 D ascites hepatoma cells showed linearity with respect to incubation concentrations. "