Myristic Acid (Tetradecanoic Acid)

A saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils. It is used to synthesize flavor and as an ingredient in soaps and cosmetics. (From Dorland, 28th ed)

Also Known As:

Networked: 168 relevant articles (3 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Giovannucci, Edward: 2 articles (08/2012 - 12/2003)
2.	Gong, Zuojiong: 1 article (01/2016)
3.	Zhang, Hong: 1 article (01/2016)
4.	Chu, Xiaogang: 1 article (01/2016)
5.	Yang, Fan: 1 article (01/2016)
6.	Li, Xun: 1 article (01/2016)
7.	Zhang, Qian: 1 article (01/2016)
8.	Wang, Luwen: 1 article (01/2016)
9.	Fabriàs, Gemma: 1 article (12/2015)
10.	Casas, Josefina: 1 article (12/2015)

Related Diseases

1.	Infection 05/01/1991 - "Our previous studies suggested that myristic acid plays a role in poliovirus assembly and in the early events of infection. " 09/01/1996 - "Thus, VSG myristoylation by free myristate may be favoured in bloodstream trypanosome infections." 09/01/1990 - "The results suggest that VP0 myristoylation plays a role in the late steps of poliovirus assembly and that the myristate moiety of VP4 may be required in the early steps of poliovirus infection." 12/06/1994 - "They are killed at 37 degrees C when placed in medium lacking myristate and, in an immunosuppressed animal model of cryptococcal meningitis, are completely eliminated from the subarachnoid space within 12 days of initial infection. " 01/01/2007 - "In these studies, we have investigated a novel inhibitor of angiogenesis, 12-methyl tetradecanoic acid (12-MTA), to treat corneal vascularisation in mouse models of corneal alkali injury and corneal Pseudomonas aeruginosa infection. "
2.	Neoplasms (Cancer) 06/01/2014 - "This growth inhibition was partially rescued by addition of the FFA, myristic acid, indicating the importance of FFA in cancer metabolism. " 01/01/1995 - "In contrast, treatment of tumor cells with 0.3 mM myristate or palmitate had no effect. " 01/01/1985 - "Comparison of the amount of [3H]myristic acid-labeled p60src in total cell lysates and in immunoprecipitates suggests that immunoprecipitation with rabbit anti-Rous sarcoma virus tumor sera detects ca. 25% of the p60src present in cells." 02/28/2015 - "Furthermore, gene expression in the tumor was increased slightly when the hydrophobic scaffold of the ssPalm was replaced from the conventionally used myristic acid (ssPalmM) to α-tocopherol succinate (ssPalmE). " 01/01/2005 - "Targeted arterial delivery of 12-MTA resulted in dose-dependent growth inhibition of intramuscular rabbit VX2 tumors while myristic acid, a saturated fatty acid of the same carbon length as 12-MTA, was found to stimulate tumor growth. "
3.	Stroke (Strokes) 01/01/2015 - "The results suggest that CVD risk factors are more extensively affected by individual FAs than hitherto recognized, and that risk for CVD, MI and stroke can be reduced by reducing the intake of palmitate, myristic acid and simple carbohydrates and improved by greater intake of linoleic acid and marine n-3 FAs."
4.	Cryptococcal Meningitis 12/06/1994 - "They are killed at 37 degrees C when placed in medium lacking myristate and, in an immunosuppressed animal model of cryptococcal meningitis, are completely eliminated from the subarachnoid space within 12 days of initial infection. "
5.	Glioma (Gliomas) 01/01/2014 - "In this study, glioma cells were isolated from surgically removed glioma tissue and stimulated by Phorbol myristate acetage (PMA) in the culture. " 12/01/1994 - "Amounts of MARCKS protein, measured by [3H]myristate labeling and western blotting, were severalfold higher in rat C6 glioma and human HTB-11 (SK-N-SH) neuroblastoma cells than in HTB-10 (SK-N-MC) or mouse N1E-115 neuroblastoma cells. " 04/01/1993 - "An 80-kDa protein labeled with [3H]myristic acid in C6 glioma and N1E-115 neuroblastoma cells has been identified as the myristoylated alanine-rich C kinase substrate (MARCKS protein) on the basis of its calmodulin-binding, acidic nature, heat stability, and immunochemical properties. " 07/01/2002 - "In the present study, by assessing the effect of a specific p38 mitogen-activated protein kinase (MAPK) inhibitor, SB203580, on the secretion of MMPs and in vitro invasion of various glioma cells, the authors attempt to define the role of the p38 MAPK pathway in the regulation of MMPs and tissue inhibitors of metalloproteinases (TIMPs) activated by phorbol ester (phorbol-12-myristate-13-acetate [PMA]) in the D54 human glioblastoma cell line. "

Related Drugs and Biologics

1.	Linoleic Acid (Linoleate)
2.	9,10-Dimethyl-1,2-benzanthracene (DMBA)
3.	anthracene
4.	Carbohydrates
5.	phorbol
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	Palmitic Acid (Hexadecanoic Acid)
8.	Cholesterol
9.	Fatty Acids (Saturated Fatty Acids)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Topical Administration