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alpha-Methyltyrosine (Metirosine)

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An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed)

Also Known As:

Metirosine; Demser; Metyrosine; DL-Tyrosine, alpha-methyl-; Merck Brand of Metyrosine; Merck Sharp & Dohme Brand of Metyrosine; Racemetirosine; alpha-MPT; alpha-Methyl-para-tyrosine; alpha-Methyltyrosine Hydrochloride; alpha-Methyltyrosine, (+,-)-Isomer; alpha-Methyltyrosine, (D,L)-Isomer; alpha-Methyltyrosine, (L)-Isomer; Hydrochloride, alpha-Methyltyrosine; Metyrosine Merck Brand; alpha MPT; alpha Methyl p tyrosine; alpha Methyl para tyrosine; alpha Methyltyrosine; alpha Methyltyrosine Hydrochloride; alpha-methyl- DL-Tyrosine; alpha-Methyl-p-tyrosine

Networked: 205 relevant articles (6 outcomes, 10 trials/studies)

Relationship Network

Drug Context: Research Results

Amino Acids, Peptides, and Proteins
- Amino Acids: 10808
  - Cyclic Amino Acids: 3
    - Aromatic Amino Acids: 282
      - Tyrosine: 7102
        Methyltyrosines
        alpha-Methyltyrosine: 205

Experts

1.	Suleyman, Halis: 5 articles (11/2012 - 05/2007)
2.	Hacimuftuoglu, Ahmet: 4 articles (07/2012 - 05/2007)
3.	Polat, Beyzagul: 3 articles (11/2012 - 01/2010)
4.	Cadirci, Elif: 3 articles (04/2010 - 05/2007)
5.	Halici, Zekai: 3 articles (04/2010 - 05/2007)
6.	Endo, Keigo: 3 articles (04/2007 - 01/2003)
7.	Oriuchi, Noboru: 3 articles (04/2007 - 01/2003)
8.	Hasler, Gregor: 2 articles (03/2015 - 10/2011)
9.	Gundogdu, Cemal: 2 articles (07/2012 - 04/2010)
10.	Albayrak, Abdulmecit: 2 articles (04/2010 - 01/2010)

Related Diseases

1.	Pheochromocytoma 04/28/1997 - "Metyrosine and pheochromocytoma." 11/01/1990 - "Surgical management of pheochromocytoma with the use of metyrosine." 05/01/1990 - "A case of malignant pheochromocytoma treated with 131I-metaiodobenzylguanidine and alpha-methyl-p-tyrosine." 11/01/1988 - "For patients with inoperable, malignant, recurrent, or multicentric pheochromocytomas, chronic medical therapy is indicated in the form of alpha- and/or beta-blockade or inhibition of catecholamine synthesis with alpha-methyl-para-tyrosine. " 11/01/1985 - "Other investigators have advocated alpha-methyltyrosine as the medical therapy of choice in the preoperative preparation of patients with pheochromocytoma. "
2.	Anoxia (Hypoxia) 01/01/1998 - "Rasagiline at 0.5 mg/kg/day was protective against alpha-MpT also in hypoxia-lesioned rats. " 04/01/1986 - "Similarly, treatment with alpha-methyl-p-tyrosine decreased the ability of chemoreceptors to respond to hypoxia and hypercapnia and, in a few instances, these receptors could only be excited by superfusion of nitrogen-equilibrated medium. " 06/01/1978 - "5. The animals were exposed to alternate periods of hypoxia and hyperoxia following administration of the tyrosine hydroxylase inhibitor alpha-methyl p-tyrosine (AMPT, 0.2-10 mg/kg, I.A.). " 08/01/1996 - "Reserpine (which depletes dopamine stores) but not alpha-methyl-para-tyrosine (which decreases de novo synthesis of dopamine) caused a marked attenuation of this hyperpolarisation [IR decrease only from 163.32 +/- 44.42 M omega pre-hypoxia to 154.42 +/- 50.97 M omega during hypoxia]. " 07/15/1996 - "Depleting the brain of catecholamines prior to hypoxia, by treating the animals with alpha-methyl-p-tyrosine (AMT), resulted in a major change in the hsp72 mRNA expression. "
3.	Body Weight (Weight, Body) 06/01/1983 - "Ten hr prior to the microinjection, alpha-methyl-p-tyrosine (250 mg/kg body weight) was intraperitoneally injected to prevent spontaneous pulsatile GH release. " 06/01/1983 - "Ethanol (1-1.5 g/kg body weight, i.p.) improved acquisition of active avoidance responding only in ALA, whereas alpha-methyl-p-tyrosine (AMPT; 80 mg/kg body weight, i.p.) seemed to selectively impair acquisition of responding in AHA. " 06/01/2010 - "fossilis collected in both prespawning and spawning phases were given alpha-methylparatyrosine (alpha-MPT: 250 microg/g body weight, ip, an irreversible inhibitor of TH) and human chorionic gonadotropin (hCG: 100 IU/fish, ip) alone or in combination. " 01/10/2000 - "Dopamine depletion was achieved by per-oral administration of 5.5 g/70 kg body weight alpha-methyl-para-tyrosine given in 37 h. " 06/01/1979 - "Morphine (1.67, 5, and 15 mg/kg of body weight, intraperitoneally) altered dopamine turnover as measured by the alpha-methyl-p-tyrosine method in the median eminence, neostriatum, and frontal cortex of male Sprague-Dawley rats. "
4.	Seasonal Affective Disorder 11/01/2001 - "Effects of alpha-methyl-para-tyrosine-induced catecholamine depletion in patients with seasonal affective disorder in summer remission."
5.	Ureteral Obstruction 11/01/2012 - "The protective effects of metyrosine, lacidipine, clonidine, and moxonidine on kidney damage induced by unilateral ureteral obstruction in rats."

Related Drugs and Biologics

1.	Phenoxybenzamine
2.	Ethanol (Ethyl Alcohol)
3.	Clonidine (ST 155)
4.	Somatostatin (Somatotropin Release-Inhibiting Factor)
5.	lacidipine
6.	moxonidine (Moxon)
7.	rasagiline (Azilect)
8.	Dopamine (Intropin)
9.	Reserpine (Serpasil)
10.	Levodopa (L Dopa)

Related Therapies and Procedures

1.	Preoperative Care
2.	Premedication
3.	Injections
4.	Drug Therapy (Chemotherapy)
5.	Oral Administration