Phenol (Carbolic Acid)

An antiseptic and disinfectant. It is active against a wide range of micro-organisms including some fungi and viruses, but is only slowly effective against spores. It has been used to disinfect skin and to relieve itching. (From Martindale, The Extra Pharmacopoeia, 30th ed, p801)

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Networked: 1403 relevant articles (70 outcomes, 121 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Campese, Vito M: 9 articles (01/2009 - 02/2002)
2.	Otto, Michael: 7 articles (10/2015 - 01/2004)
3.	Ye, Shaohua: 7 articles (01/2009 - 02/2002)
4.	Losa Iglesias, Marta Elena: 6 articles (11/2014 - 09/2008)
5.	Becerro de Bengoa Vallejo, Ricardo: 6 articles (11/2014 - 09/2008)
6.	Smith, David: 4 articles (12/2015 - 11/2012)
7.	Hanna, George B: 4 articles (12/2015 - 11/2012)
8.	Huang, Juzheng: 4 articles (12/2015 - 11/2012)
9.	Kumar, Sacheen: 4 articles (12/2015 - 11/2012)
10.	Menezes, Irwin R A: 4 articles (01/2015 - 08/2010)

Related Diseases

1.	Pain (Aches) 09/01/2012 - "The mean total dose for the lower limb muscle was 93.8 ± 63.5 U, and phenol volume was 4.1 ± 1.3 ml. There was a significant improvement in Ashworth Scale and pain scores. " 05/01/1992 - "Two weeks after the lower thoracic pain was relieved, the patient had complained of a new right-sided pain in the region of C7-T2, which was treated successfully with 10 ml 10% phenol. " 10/01/2005 - "Alcoholization with phenol in the percutaneous treatment of IDN has the purpose of provoking a permanent chemical neurolysis, obtaining remission of the neuritic pain symptoms. " 06/01/1989 - "Evaluation of neurolytic blocks using phenol and cryogenic block in the management of chronic pain." 10/01/1980 - "The effects of subarachnoid phenol blockade have been evaluated on the basis of pain relief (measured by the visual analogue test) and improved general well being. "
2.	Neoplasms (Cancer) 11/02/2006 - "The most potent inhibitor, 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol 31b (CAN508), reduced the frequency of S-phase cells of the cancer cell line HT-29 in antiproliferation assays. " 05/01/2014 - "The structure-activity relationship studies revealed that phenol groups on C3 and C6 are critical to anti-proliferative activity and C4 modification is capable to improve both anti-cancer activity and drug-like properties. " 03/01/2012 - "The purpose of this study is to assess the effectiveness of adjuvant treatment with phenol in aggressive, low grade, malignant and benign bone tumors in young patients. " 03/01/2015 - "To our knowledge, we first report subarachnoid phenol block therapy for a patient with pelvic-tumor related rectal tenesmus." 03/01/2015 - "[Successful Subarachnoid Phenol Block Therapy in a Patient with Pelvic Tumor-related Rectal Tenesmus]."
3.	Typhoid Fever (Typhoid) 05/01/2015 - "In this study, antibiotic resistance and major phenol and genotypes of non-typhoid Salmonella spp. from riversheds in Taiwan were examined. " 07/01/1942 - "Immunization against typhoid and paratyphoid with alcohol-killed, alcohol-preserved and heat-killed, phenol-preserved, vaccine." 09/24/1898 - "Treatment of Enteric Fever by Carbolic Acid at the British General Hospital, Nowshera, Punjab." 05/29/1897 - "The Treatment of Enteric Fever by Carbolic Acid." 06/24/1893 - "TYPHOID FEVER and its TREATMENT by the CARBOLIC ACID METHOD."
4.	Cicatrix (Scar) 06/01/2010 - "A 75-year-old woman (with Fitzpatrick skin type II) presented with a 4-month history of scarring, which had developed following a phenol peel for perioral rhytides. " 01/01/1999 - "Between January of 1996 and January of 1998, 30 cases of significant small pox scars were treated with phenol at the Korea University Anam Hospital. " 04/01/1992 - "Conversely, because of their more superficial nature, they also are not as effective as phenol peels in improving deep scars and wrinkles. " 05/01/2010 - "Delayed wound healing and scarring after combined ablative laser and phenol peel treatment." 08/01/2014 - "Evaluation of a new treatment for keloid scars using a 40% phenol solution in accordance with a predefined protocol. "
5.	Infection 10/01/2014 - "Our study has shown that patient in phenol group had less post operative infection, spike formation and recurrence as compared to wedge resection group only. " 02/01/2012 - "An analytic study to validate a diagnostic test was carried out at the Institute of Gastroenterology in Havana, Cuba in adult patients of both sexes in whom chromoendoscopy was carried out with red phenol at 0.1% over the gastric mucosa for the detection of Helicobacter pylori infection between November 2008 and December 2010. " 08/01/2014 - "Phenol-soluble modulins (PSMs) are recently-discovered toxins with a key impact on the development of Staphylococcus aureus infections. " 01/01/2014 - "A recently reported new method of phenol-based "soft" embalming has been found to preserve tissues in a fresh-like state over an extended period of time and simultaneously reduced infection risks. " 06/01/2013 - "How can Staphylococcus aureus phenol-soluble modulins be targeted to inhibit infection?"

Related Drugs and Biologics

1.	Glycerol (Glycerine)
2.	Typhoid-Paratyphoid Vaccines (Typhoid Vaccines)
3.	Tetracycline (Achromycin)
4.	Ethanol (Ethyl Alcohol)
5.	Glucose (Dextrose)
6.	Antigens
7.	Acetone
8.	Proteins (Proteins, Gene)
9.	Benzophenoneidum (Auramine O)
10.	Paraffin

Related Therapies and Procedures

1.	Injections
2.	Curettage
3.	Aftercare (After-Treatment)
4.	Sympathectomy (Sympathectomies)
5.	Cordotomy