Neopterin

A pteridine derivative present in body fluids; elevated levels result from immune system activation, malignant disease, allograft rejection, and viral infections. (From Stedman, 26th ed) Neopterin also serves as a precursor in the biosynthesis of biopterin.

Also Known As:

Networked: 1273 relevant articles (28 outcomes, 215 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fuchs, Dietmar: 73 articles (03/2015 - 05/2002)
2.	Fuchs, D: 34 articles (10/2015 - 01/2000)
3.	Schroecksnadel, Katharina: 19 articles (05/2011 - 09/2003)
4.	Kaski, Juan Carlos: 12 articles (03/2012 - 07/2003)
5.	Price, Richard W: 11 articles (02/2015 - 08/2005)
6.	Winkler, Christiana: 11 articles (05/2011 - 11/2003)
7.	Widner, B: 10 articles (12/2002 - 01/2000)
8.	Yaman, Halil: 9 articles (06/2014 - 02/2005)
9.	Melichar, Bohuslav: 8 articles (11/2015 - 07/2005)
10.	Hagberg, Lars: 8 articles (01/2014 - 07/2004)

Related Diseases

1.	Infection 01/01/2005 - "Neopterin is very useful in the diagnosis of viral infection. " 12/13/1991 - "Routine neopterin assay seems to be a useful step towards improved bone bank screening, since neopterin concentration is clearly increased in recent virus infections such as HIV. " 01/01/1987 - "Determination of neopterin levels may be helpful in the diagnosis of CMV infection." 11/01/2006 - "A study was conducted to assess the diagnostic sensitivity of neopterin screening of blood donors with regard to the detection of window-phase specimens of human immunodeficiency virus (HIV), hepatitis C virus (HCV), and hepatitis B virus (HBV) infection. " 11/01/2006 - "In the current study, the authors compared CKS cases with age-matched and sex-matched KSHV-seropositive controls without human immunodeficiency virus-1 infection and markers of viral control, blood counts, CD4-positive and CD8-positive lymphocytes, and serum beta-2-microglobulin and neopterin levels. "
2.	Neoplasms (Cancer) 01/01/1985 - "In 178/208 patients with subsequent treatment for gynecological cancer, neopterin levels returned to normal within 3 weeks when tumor remission was achieved but remained high or even raised when persistent or recurrent cancer was later diagnosed. " 01/01/1984 - "In patients with tumors of the genitourinary tract or with hemopoietic neoplasms, urinary neopterin levels were correlated with the tumor burden and became normal when remission was achieved. " 12/01/2010 - "This study did not reveal an association between urinary neopterin and one of these investigated "on tumor site transcripts". " 12/01/2010 - "The main objective of the present investigation was to study the urinary neopterin excretion in the context of the activation of the adaptive cellular immune system at the tumor site. " 01/01/2008 - "However, the use of neopterin as a nonspecific tumor marker requires further studies."
3.	Inflammation 01/01/2009 - "The aim of our study was to evaluate the level of neopterin in serum and cerebrospinal fluid in borreliosis and correlate it with the symptoms, markers of inflammation in cerebrospinal fluid (CSF), and serological tests against Borrelia burgdorferi. " 01/01/1998 - "The aim of our study was (a) to establish a range of normal CSF neopterin concentrations in control children, and (b) to inquire into the diagnostic potential of neopterin measurements in both body compartments for aiding in differential diagnosis of inflammatory vs noninflammatory diseases, and CNS vs peripheral inflammations. " 08/01/1991 - "Our study suggests that the raised serum neopterin level may be a marker of myocardial inflammation and unfavourable prognosis in patients with a clinical diagnosis of dilated heart muscle disease." 11/01/2015 - "At present, we do not suggest that neopterin should be measured routinely before heart surgery, but our findings support the hypothesis of the role of oxidative stress and inflammation in development of cardiac dysfunction following heart surgery." 10/01/2015 - "Significantly higher serum neopterin values were found in DPR(+) patients (p = 0.034) and in ANX(+) subjects (p = 0.008), as a marker of Th1-related inflammation. "
4.	Nephrotic Syndrome (Syndrome, Nephrotic) 07/01/2006 - "Serum neopterin levels were measured by ELISA in 38 children with active primary nephrotic syndrome (group I) and 17 children with primary nephrotic syndrome in remission (group II) and 20 healthy controls. " 07/01/2006 - "Serum neopterin could be used as a marker of the activity of primary nephrotic syndrome but it could not be used to differentiate between steroid-sensitive and steroid-resistant patients." 07/01/2006 - "To assess the changes that occurs in serum neopterin levels in children with primary nephrotic syndrome. " 07/01/2006 - "Serum neopterin levels in children with primary nephrotic syndrome." 10/01/1999 - "Increased serum and urinary neopterin in nephrotic syndrome indicate cell-mediated immune dysfunction."
5.	HIV Infections (HIV Infection) 10/01/1994 - "The results of this study suggest that serum neopterin is a marker for severity of clinical illness and that HBsAg+ status increases the mortality rate among children with clinical evidence of HIV infection." 01/01/1989 - "A study was undertaken in homosexual male subjects followed at 6 month intervals for 3 or more years to determine the value of serum neopterin changes induced by HIV infection. " 05/01/2015 - "Viremic HIV infection was associated with an accelerated rate of change of some monocyte activation markers (eg, neopterin) with age, whereas in VS individuals, subsequent age-related changes occurred at a similar rate as in controls, albeit at a higher absolute level. " 04/01/2002 - "Neopterin measurements are also useful to monitor therapy in patients with autoimmune disorders and in individuals with HIV infection. " 10/01/1996 - "Thus, besides the role of neopterin as sensitive indicator of disease activity in HIV infection, neopterin derivatives apparently are associated with the cascade of events that regulate the HIV production in infected individuals."

Related Drugs and Biologics

1.	Interferon-gamma (Interferon, gamma)
2.	Interleukin-6 (Interleukin 6)
3.	beta 2-Microglobulin (beta 2 Microglobulin)
4.	Interleukin-2 (IL2)
5.	Biopterin
6.	Cytokines
7.	Biological Markers (Surrogate Marker)
8.	Tryptophan (L-Tryptophan)
9.	Interleukin-2 Receptors (IL 2 Receptor)
10.	Interleukins

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Immunotherapy
3.	Drug Therapy (Chemotherapy)
4.	Coronary Atherectomy
5.	Transplantation (Transplant Recipients)