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Linoleic Acid (Linoleate)

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A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed)

Also Known As:

Linoleate; Linoelaidic Acid; 9,12-Octadecadienoic Acid; 9-trans,12-trans-Octadecadienoic Acid; Linoelaidic Acid, (E,Z)-Isomer; Linoleic Acid, (E,E)-Isomer; Linoleic Acid, (Z,E)-Isomer; Linoleic Acid, (Z,Z)-Isomer; Linoleic Acid, (Z,Z)-Isomer, 14C-Labeled; Linoleic Acid, Ammonium Salt, (Z,Z)-Isomer; Linoleic Acid, Calcium Salt, (Z,Z)-Isomer; Linoleic Acid, Potassium Salt, (Z,Z)-Isomer; Linoleic Acid, Sodium Salt, (E,E)-Isomer; Linoleic Acid, Sodium Salt, (Z,Z)-Isomer; Linolelaidic Acid; cis,cis-9,12-Octadecadienoic Acid; trans,trans-9,12-Octadecadienoic Acid; 9 trans,12 trans Octadecadienoic Acid; 9,12 Octadecadienoic Acid; Acid, 9,12-Octadecadienoic

Networked: 1820 relevant articles (67 outcomes, 242 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 18571
- Fatty Acids: 6864
  - Unsaturated Fatty Acids: 3881
    - Essential Fatty Acids: 522
      - Linoleic Acids: 51
        Linoleic Acid: 1820
        crepenynic acid
    - Omega-6 Fatty Acids: 283
      - Linoleic Acids: 51
        Linoleic Acid: 1820
        crepenynic acid

Experts

1.	Dauchy, Robert T: 21 articles (01/2015 - 02/2002)
2.	Blask, David E: 21 articles (01/2015 - 02/2002)
3.	Sauer, Leonard A: 17 articles (01/2014 - 02/2002)
4.	Dauchy, Erin M: 13 articles (01/2015 - 04/2003)
5.	Belury, Martha A: 11 articles (06/2015 - 01/2003)
6.	Krause, Jean A: 11 articles (08/2007 - 07/2002)
7.	Hibbeln, Joseph R: 9 articles (08/2015 - 01/2009)
8.	Hontecillas, Raquel: 9 articles (06/2013 - 07/2002)
9.	Bassaganya-Riera, Josep: 9 articles (06/2013 - 07/2002)
10.	Ip, Margot M: 9 articles (12/2011 - 01/2002)

Related Diseases

1.	Neoplasms (Cancer) 04/19/1995 - "Growth inhibition was statistically significant (P < .05) and most effective in association with the diets containing 8% of either omega-3 fatty acid, where tumors were smaller than those in the group fed the diet containing 8% linoleic acid alone at all time points after the 2nd week. " 12/20/2004 - "While linoleic acid exerted different effects, ranging from inhibitory to neutral, even promoting growth, conjugated linoleic acid inhibited growth in all lines tested and was particularly effective against the more malignant cells, with the exception of mammary tumor cells, in which behavior was the opposite, the more malignant cell line being less affected. " 01/01/2006 - "In vitro, the main fatty acid in vegetable oil, linoleic acid, reduced the efficacy of CLA toxicity on mammary tumor cells in culture. " 01/01/1992 - "In particular, diets enriched with linoleic acid have been consistently found to be effective in enhancing the metastatic potential of murine mammary tumors. " 01/01/1997 - "The mammary carcinogenesis results showed that the efficacy of tumor suppression by CLA was not affected by linoleate intake. "
2.	Obesity 12/01/2012 - "Preventive effects of conjugated linoleic acid on obesity by improved physical activity in nescient basic helix-loop-helix 2 knockout mice during growth period." 12/01/2012 - "The purpose of this study was to evaluate whether conjugated linoleic acid (CLA) exposure during the developmental period increases voluntary activity, which would influence obesity outcome later in life. " 11/07/2012 - "Caenorhabditis elegans as a model to study the effectiveness and metabolic targets of dietary supplements used for obesity treatment: the specific case of a conjugated linoleic acid mixture (Tonalin)." 12/01/2006 - "This study is designed to evaluate whether the PEGylated conjugated linoleic acid (PCLA) as the pro-drug can have favorable stability, bioavailability, and anti-adipogenic activity in 3T3-L1 cells for anti-obesity when compared with conjugated linoleic acid (CLA) itself. " 11/01/2015 - "To demonstrate the compounds, linoleic acid was analyzed by using gas chromatography; and the anti-obesity effects and possible mechanisms of ATE were examined in 3T3-L1 adipocytes and HFD-induced obese mice. "
3.	Atherosclerosis 06/01/2005 - "Conjugated linoleic acid (CLA) is a group of positional and geometric isomers of linoleic acid (LA, C18:2 cis-9, cis-12) that are reported to have important biological activities, including protection against atherosclerosis. " 05/01/1989 - "Our present results further support the importance of linoleic acid in the protection against atherosclerosis. " 01/01/2010 - "Animal studies suggest that dietary cis-9,trans-11 (c9,t11) conjugated linoleic acid (CLA) may inhibit or regress the development of atherosclerosis. " 08/01/2008 - "Conjugated linoleic acid and atherosclerosis: studies in animal models." 08/01/2006 - "Several studies have shown that conjugated linoleic acid (CLA) supplementation can improve the plasma lipid profile and thereby probably decrease the risk for development of atherosclerosis. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2003 - "The present study suggests that higher serum proportions of the n-6 PUFA linoleic acid and lower proportions of the MUFA trans-11-18:1 fatty acid predict a reduced incidence of breast cancer." 04/01/2006 - "Additionally, conjugated linoleic acid, a fatty acid found naturally in dairy fat, confers a wide range of anticarcinogenic benefits in experimental animal models and is especially consistent for protection against breast cancer." 03/01/2006 - "Conjugated linoleic acid (CLA), a naturally occurring linoleic acid isomer found in ruminant-produced foods, has the potential to serve as an effective chemopreventive nutriceutical factor for breast cancer prevention based upon previous published studies. " 02/01/2006 - "In this study, we investigated the effects of conjugated linoleic acid (CLA) on COX-2 transcription in MCF-7 breast cancer cells. " 08/07/1997 - "The primary objective of our ecological study was to investigate the association between breast-cancer incidence and linoleic acid status across European countries. "
5.	Overweight 03/01/2012 - "The efficacy of long-term conjugated linoleic acid (CLA) supplementation on body composition in overweight and obese individuals: a systematic review and meta-analysis of randomized clinical trials." 09/01/2006 - "Results of a pilot study suggested that cis-9, trans-11 conjugated linoleic acid (CLA) improved LDL phenotype in moderately overweight subjects with LDL phenotype B. " 06/01/2015 - "The objective of this study was to determine the extent to which a low level of trans-10, cis-12 (10,12) conjugated linoleic acid (CLA) decreases adiposity and increases browning in overweight mice, its dependence on inflammatory signaling and potential synergistic effects of daily exercise. " 05/01/2010 - "Evaluation of the antiobesity effects of an amino acid mixture and conjugated linoleic acid on exercising healthy overweight humans: a randomized, double-blind, placebo-controlled trial." 01/01/2007 - "A study was conducted to investigate the short-term safety of dietary conjugated linoleic acid (CLA) in overweight Japanese male volunteers. "

Related Drugs and Biologics

1.	alpha-Linolenic Acid (Linolenic Acid)
2.	Fatty Acids (Saturated Fatty Acids)
3.	Oleic Acid (Oleate)
4.	Calcium
5.	8,11,14-Eicosatrienoic Acid (DHLA)
6.	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)
7.	Safflower Oil
8.	Paclitaxel (Taxol)
9.	Triglycerides (Triacylglycerol)
10.	Carbon Monoxide

Related Therapies and Procedures

1.	Vegetarian Diet (Vegetarianism)
2.	Total Parenteral Nutrition
3.	Enzyme Therapy
4.	Resistance Training
5.	Bariatric Surgery