CXCR4 Receptors (CXCR4 Receptor)

CXCR receptors with specificity for CXCL12 CHEMOKINE. The receptors may play a role in HEMATOPOIESIS regulation and can also function as coreceptors for the HUMAN IMMUNODEFICIENCY VIRUS.

Also Known As:

CXCR4 Receptor; Fusin; Receptors, CXCR4; LESTR Receptor; Leukocyte-Derived Seven-Transmembrane Domain Receptor; Receptor, LESTR; Leukocyte Derived Seven Transmembrane Domain Receptor; Receptor, CXCR4; CXC Chemokine Receptor 4

Networked: 819 relevant articles (13 outcomes, 90 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Scala, Stefania: 8 articles (11/2020 - 03/2005)
2.	Luker, Gary D: 7 articles (01/2018 - 06/2009)
3.	Luker, Kathryn E: 7 articles (01/2018 - 06/2009)
4.	Hattermann, Kirsten: 7 articles (04/2016 - 04/2010)
5.	Botti, Gerardo: 6 articles (11/2020 - 03/2005)
6.	Mentlein, Rolf: 6 articles (07/2014 - 04/2010)
7.	Bajetto, Adriana: 6 articles (01/2014 - 11/2002)
8.	Florio, Tullio: 6 articles (01/2014 - 11/2002)
9.	Schulz, Stefan: 5 articles (07/2022 - 01/2008)
10.	Rubin, Joshua B: 5 articles (02/2021 - 11/2003)

Related Diseases

1.	Neoplasms (Cancer) 12/13/2022 - "In particular, we show that senescent tumor cells in cell cycle arrest can block intratumoral infiltration of CD8+ T cells by secreting a high level of CXCL12, which leads to significant reduction its receptors, CXCR4, on T cells, and thus impaired chemotaxis. " 03/01/2010 - "Previous studies have indicated that BMDCs are recruited to tumors in part through the interaction between the HIF-1-dependent stromal cell-derived factor-1 (SDF-1) and its receptor, CXCR4. " 10/31/2023 - "Its interaction with its cognate receptor, CXCR4, initiates a cascade of events that not only shapes the metastatic potential of tumor cells but also defines the niches within the secondary organs that support metastatic colonization. " 10/25/2023 - "Therefore, the findings indicate this designed radioligand could be used as a potential SPECT imaging agent in highly proliferated CXCR4 receptor tumors." 08/01/2023 - "CXC chemokine receptor 4 (CXCR4) blockade in cancer treatment."
2.	Neoplasm Metastasis (Metastasis) 01/06/2023 - "Our results suggest that the activation of the CXCR4 receptor is a conserved evolutionary response that can increase cell proliferation, migration, and consequent metastasis. " 09/29/2015 - "Moreover, an allosteric inhibitor of the CXCR4 receptor prevented the metastasis-associated cellular activities stimulated by the secretome of irradiated lung epithelial cells. " 08/01/2012 - "SDF-1 and its specific receptor, CXCR4, are now receiving attention as a mechanism of cell progression and metastasis. " 05/01/2009 - "Stromal cell-derived factor-1 (SDF-1) and its receptor CXCR4 are implicated in tumour chemotaxis and metastasis. " 11/03/2006 - "On this basis, we hypothesized that the biological axis of CXCL12 via interaction with its receptor, CXCR4, is a major mechanism for RCC metastasis. "
3.	Breast Neoplasms (Breast Cancer) 03/01/2020 - "In this study, we found that minecoside downregulates constitutive CXC chemokine receptor 4 expression in MDA-MB-231 breast cancer cells. " 01/01/2012 - "In this study, we found that HGF induced functional CXCR4 receptor expression in breast cancer cells. " 06/01/2006 - "The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study." 01/01/2019 - "CXCL12 and its receptors CXCR4 and CXCR7 play a crucial role in the progress of breast cancer. " 01/01/2018 - "The CXC chemokine receptor 4 (CXCR4) expression was found to be correlated with poor overall survival in invasive breast carcinoma patients. "
4.	Prostatic Neoplasms (Prostate Cancer) 10/01/2023 - "Findings suggest that CXCR4 receptor may be one of the ways to worsen the prognosis of prostatic cancer." 01/01/2019 - "Stromal cell-derived factor-1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) have been found to be tightly correlated with the progression of prostate cancer (PC). " 11/04/2008 - "CXCL12 and its receptor CXCR4 along with MMP-2 and MMP-9 are related with prostate cancer perineural invasion." 01/01/2008 - "Stromal derived factor-1 (SDF-1 or CXCL12) expressed by osteoblasts and endothelial cells, and its receptors CXCR4 and CXCR7/RDC1 are key molecular determinants in prostate cancer (PCa) metastasis. " 01/01/2022 - "Prognostic significance of SDF-1 chemokine and its receptors CXCR4 and CXCR7 involved in EMT of prostate cancer."
5.	Colitis 08/01/2018 - "Mesenchymal stem cells and CXC chemokine receptor 4 overexpression improved the therapeutic effect on colitis via mucosa repair." 08/01/2018 - "The present study intended to observe the homing capability and therapeutic effect of CXC chemokine receptor 4 (CXCR-4) gene overexpressed bone marrow mesenchymal stem cells (BMSCs) on colitis, and to study the possible mechanisms involved. " 01/01/2011 - "Previous studies demonstrated that CXC chemokine receptor 4 (CXCR4) antagonists could reduce colonic inflammation and mucosal damage in dextran sulfate sodium (DSS)-induced colitis. " 06/21/2010 - "To investigate the effects of the chemokine stromal cell-derived factor-1 (CXCL12) receptor (CXCR4) antagonist AMD3100 on colonic inflammation and epithelial barrier in dextran sulfate sodium (DSS)-induced colitis in mice. "

Related Drugs and Biologics

1.	Chemokine CXCL12
2.	Ligands
3.	plerixafor
4.	Paraffin
5.	Therapeutic Uses
6.	Docetaxel (Taxotere)
7.	CCR5 Receptors (CCR5 Receptor)
8.	68Ga-pentixafor
9.	Bovine Serum Albumin
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Intravenous Infusions
2.	Therapeutics
3.	Cell- and Tissue-Based Therapy (Cell Therapy)
4.	Highly Active Antiretroviral Therapy (HAART)
5.	Transplantation