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CXCR4 Receptors (CXCR4 Receptor)

Subscribe to New Research on CXCR4 Receptors

CXCR receptors with specificity for CXCL12 CHEMOKINE. The receptors may play a role in HEMATOPOIESIS regulation and can also function as coreceptors for the HUMAN IMMUNODEFICIENCY VIRUS.

Also Known As:

CXCR4 Receptor; Fusin; Receptors, CXCR4; LESTR Receptor; Leukocyte-Derived Seven-Transmembrane Domain Receptor; Receptor, LESTR; Leukocyte Derived Seven Transmembrane Domain Receptor; Receptor, CXCR4; CXC Chemokine Receptor 4

Networked: 847 relevant articles (8 outcomes, 79 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fujii, Nobutaka: 14 articles (03/2014 - 03/2002)
2.	Scala, Stefania: 10 articles (10/2015 - 03/2005)
3.	Tamamura, Hirokazu: 10 articles (07/2011 - 03/2002)
4.	Chu, Quyen D: 8 articles (09/2012 - 07/2007)
5.	Li, Benjamin D L: 8 articles (09/2012 - 07/2007)
6.	Franco, Renato: 8 articles (02/2012 - 03/2005)
7.	Luker, Gary D: 7 articles (11/2015 - 12/2004)
8.	Luker, Kathryn E: 7 articles (11/2015 - 12/2004)
9.	Schulz, Stefan: 7 articles (09/2015 - 01/2008)
10.	Oishi, Shinya: 7 articles (03/2014 - 03/2002)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2010 - "Previous studies have indicated that BMDCs are recruited to tumors in part through the interaction between the HIF-1-dependent stromal cell-derived factor-1 (SDF-1) and its receptor, CXCR4. " 09/29/2015 - "An overexpression of the chemokine receptor CXCR4, in contrast, is considered to be present mainly in highly proliferative and advanced tumors. " 07/01/2015 - "Stromal cell-derived factor (SDF-1) and its receptor, CXCR4, play multiple roles in migration, proliferation, and survival of different tumor cells. " 02/20/2015 - "For many tumors, the overexpression of the chemokine receptor CXCR4 is associated with increased malignancy and poor patient outcomes. " 02/20/2015 - "Differential expression and prognostic value of the chemokine receptor CXCR4 in bronchopulmonary neuroendocrine neoplasms."
2.	Stroke (Strokes) 01/01/2012 - "This study investigated the role of stromal cell-derived factor-1α (SDF-1α)/CXC chemokine receptor 4 (CXCR4) axis in brain and endothelial progenitor cells (EPCs), and explored the efficacy of CXCR4 primed EPCs in treating ischemic stroke in diabetes. " 08/21/2008 - "The chemokine receptor CXCR4 and its ligand, stromal cell derived factor-1 alpha (SDF1 alpha) regulate neuroblast migration towards the ischemic boundary after stroke. " 08/01/2013 - "We show here that rats housed in EE after stroke induced by permanent occlusion of the middle cerebral artery (pMCAO), showed attenuated levels of proinflammatory cytokines in the ischemic core and the surrounding peri-infarct area, including a significant reduction in the stroke-induced chemokine receptor CXCR4 and its natural ligand stromal cell-derived factor-1 (CXCL12). " 04/01/2011 - "VSELs express early cardiac and endothelial lineages markers (GATA-4, Nkx2.5/Csx, VE-cadherin, and von Willebrand factor), SDF-1 chemokine receptor CXCR4, and undergo rapid mobilization in acute MI and ischemic stroke. "
3.	Neoplasm Metastasis (Metastasis) 07/01/2009 - "Recent studies have demonstrated that the chemokine receptor CXCR4 plays a crucial role in organ-specific metastasis formation. " 09/29/2015 - "Moreover, an allosteric inhibitor of the CXCR4 receptor prevented the metastasis-associated cellular activities stimulated by the secretome of irradiated lung epithelial cells. " 12/28/2014 - "As the antagonist of chemokine receptor CXCR4, Peptide S exhibited anti-metastasis effect. " 03/04/2014 - "CXC chemokine receptor 4 (CXCR4) and its ligand stromal cell-derived factor-1α (SDF-1α, also known as CXCL12) have important roles in promoting tumour growth and metastasis. " 01/01/2014 - "Our results show that AEG-1 activates the expression of the metastasis-associated chemokine receptor CXCR4, and that its ligand, CXCL12, is secreted by HPMECs. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2012 - "In this study, we found that HGF induced functional CXCR4 receptor expression in breast cancer cells. " 06/01/2006 - "The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study." 07/01/2015 - "The objective of this work is to quantify the density, spatial organization, and magnitude of binding of the CXCR4 receptor on live metastatic breast cancer (MBC) cells. " 07/01/2015 - "Mapping the CXCR4 receptor on breast cancer cells." 09/01/2014 - "The chemokine receptor CXCR4 also regulates the development of breast cancer by stimulating cell migration towards CXCL12-expressing sites of metastatic spread. "
5.	Infection 01/01/1999 - "Recent studies have identified the chemokine receptor CXCR4 as the major receptor for cell culture-adapted strains of FIV, suggesting that FIV and human immunodeficiency virus (HIV) share a common mechanism of infection involving an interaction between the virus and a member of the seven transmembrane domain superfamily of molecules. " 12/15/1998 - "In this study, we report that HHV-7 infection also causes a progressive loss of the surface CXC-chemokine receptor 4 (CXCR4) in CD4(+) T cells, accompanied by a reduced intracellular Ca2+ flux and chemotaxis in response to stromal cell-derived factor-1 (SDF-1), the specific CXCR4 ligand. " 08/01/2012 - "CXC chemokine receptor 4 was upregulated on the RPMI 8226 cells after Epstein-Barr virus infection. " 12/16/2010 - "CXCL12 and its receptors, CXCR4 and CXCR7, are linked to tumorigenesis, and we reported that abnormal expression of CXCL12 in epidermal keratinocytes correlates with HPV infection. " 05/01/2010 - "As it does in vivo, human cervico-vaginal tissue ex vivo preferentially supports the productive infection of R5 HIV-1 rather than that of X4 HIV-1 in spite of the broad expression of CXC chemokine receptor 4 (CXCR4). "

Related Drugs and Biologics

1.	Chemokine CXCL12
2.	JM 3100
3.	docetaxel (Taxotere)
4.	CCR5 Receptors (CCR5 Receptor)
5.	Cytokines
6.	Phosphotransferases (Kinase)
7.	Ligands
8.	Chemokine Receptors
9.	Street Drugs (Illicit Drugs)
10.	Paraffin

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Tissue Therapy (Cell Therapy)
3.	Intravenous Infusions
4.	Highly Active Antiretroviral Therapy (HAART)
5.	Transplantation (Transplant Recipients)