Tissue Inhibitor of Metalloproteinase-3

05/01/2014 - "TIMP-3 is highly expressed in the heart and is markedly downregulated in patients with ischaemic cardiomyopathy. "
11/01/2014 - "Gel-released TIMP-1 and TIMP-3 significantly improved cardiac function and myocardial remodeling and enhanced SMA expression in the infarcted area in ischemic cardiomyopathy model rats. "
01/01/2012 - "Inhibiting matrix metalloproteinase by cell-based timp-3 gene transfer effectively treats acute and chronic ischemic cardiomyopathy."
07/01/2007 - "In conclusion, chronic doxorubicin cardiomyopathy was characterized by increased MMP and decreased TIMP-3 expression. "

04/01/2022 - "As a result of this study, it was concluded that ADAMTS-1 and -9 and TIMP-3 might have a role in pulpal inflammation, whereas ADAMTS-4 was not related to pulpal inflammation."
01/01/2021 - "In this study, we investigated the role of TIMP-3 in regulating inflammation in the diabetic retina. "
04/01/2013 - "This study demonstrated that iNOS, TIMP-3, and TIMP-4 might be involved in the progression of periodontal inflammation associated with type 2 DM. "
12/21/2019 - "Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a component of the extracellular environment, where it mediates diverse processes including matrix regulation/turnover, inflammation and angiogenesis. "
01/01/2019 - "The role of TIMP-3 in the regulating inflammation and novel therapeutic target of nAMD needs to be further studied."

12/27/2018 - "The present study aims to investigate the involvement of TIMP-3 in the chemoresistance of laryngeal carcinoma. "
01/01/2023 - "To investigate the distribution of single nucleotide polymorphism (SNP) of tissue inhibitor of metalloproteinases-3 (TIMP-3) in patients with/without urothelial cell carcinoma (UCC), three loci of TIMP-3 SNPs (rs9862 C/T, rs9619311 T/C, rs11547635 C/T) were genotyped via TaqMan allelic discrimination for 424 UCC patients and 848 non-UCC participants. "
12/01/2020 - "Remarkably, TIMP-3 expression gradually decreased during progression of human dysplastic lesions into cervical carcinoma. "
12/27/2018 - "We showed that TIMP-3 expression was significantly decreased in chemoresistant laryngeal carcinoma tissues compared with chemosensitivity tissues. "
07/01/2018 - "The results of immunohistochemical staining revealed that the positive expression rate of MMP-2 was 57.6% in GCT tissues and 18.9% in para-carcinoma tissues, while that of TIMP-3 was 63.2% in GCT tissues and 13.8% in para-carcinoma tissues, and the differences were statistically significant (P<0.01). "

07/01/2008 - "AGTR2 treatment was found to be more effective in inhibiting ovarian cancer growth than the treatment with TIMP-3 in parallel experiments. "
12/01/2021 - "The aim of this study was to evaluate the association of TIMP3 protein expression with ovarian cancer (OC) clinicopathological features and survival outcomes.Patients"
03/08/2007 - "Our data indicate that inactivation of TIMP-3 by somatic mutation or promoter hypermethylation is rare in ovarian cancer."
03/08/2007 - "We analyzed 65 ovarian cancers for both somatic genetic mutations and TIMP-3 promoter hypermethylation. "
03/08/2007 - "TIMP-3 has not previously been investigated for somatic mutations or promoter hypermethylation in ovarian cancer. "

01/01/2017 - "Our research highlights the meaningful role of MMP-3, MMP-9 and TIMP-3 in psoriasis pathogenesis and clearance of disease symptoms. "
01/01/2017 - "This study was designed to investigate the plasma levels of MMP-3, MMP-9 and TIMP-3 in plaque psoriasis patients prior to and following a course of ultraviolet B narrowband treatment with respect to disease advancement. "
02/01/2022 - "We found that most cases with guttate psoriasis and with induced plaque psoriasis cases showed high expression of TIMP-3 expression and decreased or poorly increased levels of miR-21. "
04/01/2018 - "These results indicate the usefulness and high diagnostic power of TIMP-3 in early detection of psoriasis. "
04/01/2018 - "In the total psoriasis patients group, the largest area under the ROC curve was obtained for TIMP-3. "