Tissue Inhibitor of Metalloproteinase-1

A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a N-glycosylated protein, molecular weight 28 kD, produced by a vast range of cell types and found in a variety of tissues and body fluids. It has been shown to suppress metastasis and inhibit tumor invasion in vitro.

Also Known As:

Networked: 2251 relevant articles (69 outcomes, 381 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Brünner, Nils: 51 articles (09/2015 - 01/2002)
2.	Sorsa, Timo: 32 articles (09/2015 - 06/2006)
3.	Tervahartiala, Taina: 27 articles (09/2015 - 06/2006)
4.	Nielsen, Hans Jørgen: 15 articles (09/2015 - 01/2002)
5.	Christensen, Ib Jarle: 15 articles (09/2015 - 01/2002)
6.	Turpeenniemi-Hujanen, Taina: 14 articles (08/2012 - 08/2003)
7.	Brünner, N: 13 articles (02/2011 - 11/2000)
8.	Schrohl, Anne-Sofie: 12 articles (09/2013 - 03/2003)
9.	Krüger, Achim: 10 articles (08/2015 - 11/2004)
10.	Jensen, Vibeke: 10 articles (09/2014 - 01/2002)

Related Diseases

1.	Fibrosis (Cirrhosis) 01/01/2015 - "It also effectively improved the degree of myocardial fibrosis in partial abdominal aortic rats and it had a tendency to have a greater effect with longer treatment duration, which is related to the mechanism of regulation of MMP-1 and TIMP-1 expression in the myocardial rat. " 10/01/2004 - "Diagnostic accuracy improved using logistic regression combining (i) CL-IV, TIMP-1, PH to identify CFLD (AUC 0.831, P<0.0001) and (ii) TIMP-1, PH to identify CFLD patients with no fibrosis (AUC 0.852, P<0.02). " 01/01/2012 - "The present study evaluates whether transplanted mouse ES cells overexpressing TIMP-1, an antiapoptotic and antifibrotic protein, can enhance cardiac myocyte differentiation, inhibit native cardiac myocyte apoptosis, reduce fibrosis, and improve cardiac function in the infarcted myocardium. " 10/15/2010 - "In conclusion, the present study implied that the TGF-β1-TIMP-1 pathway is activated in dystrophic muscles and the overexpression of TIMP-1 may result in increased deposition of extracellular matrix leading to tissue fibrosis." 03/01/2008 - "A 3-variable model consisting of serum HA, TIMP-1, and platelet count was better than other published models in identifying cirrhosis in HALT-C Trial subjects. "
2.	Neoplasms (Cancer) 08/01/2012 - "In our study, tissue inhibitor of metalloproteinase-1 expression was significantly related to markers of tumor aggressiveness and was a powerful indicator of poorer prognosis, with a difference in 10-year disease-free and overall survival of 14% and 28%, respectively, between tissue inhibitor of metalloproteinase-1-negative and tissue inhibitor of metalloproteinase-1-positive cases. " 01/01/2014 - "However, patients with TIMP-1 positive tumors had a significant reduction in OS events (hazard ratio = 0.71, 95% confidence interval (CI) = 0.52-0.98, P = 0.03). " 05/01/2001 - "TIMP-1 protein was significantly greater in tumors with lymphatic vessel invasion, an infiltrative pattern into the surrounding tissue (INF-gamma), and in tumors from patients with Stage III disease. " 05/01/2001 - "Significantly greater TIMP-1 concentrations were found in tumors that were exposed to the serosal surface compared with tumors that were limited to the submucosal layer. " 05/01/2001 - "Tissue TIMP-1 concentrations were significantly greater in gastric tumors than in normal gastric mucosa and were associated significantly with a variety of pathologic factors, including macroscopic type, depth of tumor invasion in the gastric wall, presence of lymphatic vessel invasion, pattern of tumor infiltration into the surrounding tissue, and disease stage. "
3.	Liver Cirrhosis (Hepatic Cirrhosis) 03/01/2008 - "(2) In contrast to the model group, all four drugs dramatically reduced the amount of Hyp and MDA, increased SOD activity and reduced the degrees of liver fibrosis and the expressions of TIMP-1 and TGFbeta1 in liver tissues (P<0.05 or 0.01). " 10/01/2002 - "In conclusion, TIMP-1 significantly attenuated spontaneous resolution of liver fibrosis by the combination of a net reduction of the MMP activity and suppression of apoptosis in HSC." 05/01/2011 - "In conclusion, the present study showed for the first time the mode of TIMP-1 and -2 expression and activity in the early stage of PS-induced rat liver fibrosis model." 05/01/2011 - "In the present study, we examined the changes in TIMP-1 and -2 expressions in the early stage of porcine serum (PS)-induced liver fibrosis in Brown Norway (BN) and Wistar rats. " 03/04/2011 - "Our study demonstrated, using 2 experimental murine models, that loss of MMP-2 exacerbates liver fibrosis, and suggested that MMP-2 suppresses tissue inhibitor of metalloproteinase 1 up-regulation during liver fibrosis."
4.	Inflammation 08/01/2007 - "It seems that moderately increased levels of TIMP-1 could reflect degree of activity of skin inflammation, whereas markedly increased levels could contribute to the maintenance of the remission of disease." 01/01/2013 - "In this study pSP was found to regulate excessive inflammation by modulating the balance between MMP-9 and TIMP-1 expression. " 06/01/2012 - "This study investigates MMP-9 and TIMP-1 concentrations and MMP-9 activity at different time points after major surgery when a state of noticeable inflammation is expected. " 11/01/2015 - "TIMP-1 and MMP-9 levels with conventional inflammation markers were determined. " 08/01/2015 - "This may provide a link to clinical observations, where TIMP-1 correlates with high severity and bad prognosis in inflammation-associated diseases. "
5.	Colorectal Neoplasms (Colorectal Cancer) 09/01/2015 - "Plasma TIMP-1 and CEA as Markers for Detection of Primary Colorectal Cancer: A Prospective Validation Study Including Symptomatic and Non-symptomatic Individuals." 12/01/2014 - "The present study has identified a strong significant association between high plasma TIMP-1 levels and short survival in patients with colorectal cancer. " 12/01/2014 - "The aim of this study was to assess the level of TIMP-1 in serum and its expression in patients with colorectal cancer (CRC). " 01/01/2011 - "Plasma TIMP-1 and CEA in detection of primary colorectal cancer: a prospective, population based study of 4509 high-risk individuals." 12/01/2010 - "Preoperative plasma TIMP-1 is an independent prognostic indicator in patients with primary colorectal cancer: a prospective validation study."

Related Drugs and Biologics

1.	Tissue Inhibitor of Metalloproteinase-2
2.	Matrix Metalloproteinases
3.	Messenger RNA (mRNA)
4.	Collagen
5.	Transforming Growth Factor beta1 (TGF beta 1)
6.	Transforming Growth Factor beta (TGF-beta)
7.	Tissue Inhibitor of Metalloproteinases (TIMP)
8.	Matrix Metalloproteinase 2 (Gelatinase A)
9.	Interleukin-6 (Interleukin 6)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Combination Drug Therapy (Combination Chemotherapy)
3.	Transplants (Transplant)
4.	Aftercare (After-Treatment)
5.	Transplantation (Transplant Recipients)