Tissue Inhibitor of Metalloproteinases (TIMP)

A family of secreted proteins (TIMP-1; TIMP-2; and TIMP-3) that play a crucial role in regulating the activity of the secreted METALLOENDOPEPTIDASES; (COLLAGENASES; stromelysins; GELATINASES). Of the three characterized, only TIMP-1 and TIMP-2 appear to have related primary structures and inhibitory properties. They influence the activation of the prometalloproteinase and act to modulate proteolysis of extracellular matrix, notably during tissue remodeling and inflammatory processes. On certain cell types, they can exhibit growth factor-like activity, and they can inhibit the tumorigenic and metastatic phenotype in cancer cells. (Pharmacol Ther 1993;59:329-41)

Also Known As:

Networked: 1460 relevant articles (27 outcomes, 189 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sorsa, Timo: 14 articles (08/2015 - 10/2006)
2.	Spinale, Francis G: 13 articles (06/2012 - 12/2002)
3.	Brünner, Nils: 12 articles (04/2015 - 01/2002)
4.	Tervahartiala, Taina: 9 articles (08/2015 - 10/2006)
5.	Edwards, Dylan R: 7 articles (01/2015 - 03/2003)
6.	Tyagi, Suresh C: 7 articles (12/2013 - 06/2005)
7.	Tanus-Santos, Jose E: 6 articles (01/2015 - 08/2007)
8.	Okada, Yasunori: 6 articles (09/2014 - 06/2003)
9.	Kassiri, Zamaneh: 6 articles (07/2014 - 08/2010)
10.	Papakonstantinou, Eleni: 6 articles (06/2013 - 10/2003)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2014 - "In this study, we found that unbalanced expression of MMP/TIMP axis genes in tumors was correlated with aberrant epigenotypes in the various gene promoters. " 08/01/2013 - "Hundred and forty-five cases are included in the study, and levels of MMP/TIMP expressions are assessed in three tissue compartments (i.e., tumor, stroma and normal glands) with immunohistochemistry. " 01/01/2013 - "Further stratified analysis using a case-only study approach revealed that there was no effect of MMP-2/TIMP-2 polymorphisms on early and advanced stages of cervical cancer. " 01/01/2012 - "These studies show that HSA/TIMP-2 potentiates anti-angiogenic activity by modulating MMP-2 expression, but not MMP-2 activity, to subsequently suppress tumor growth, suggesting an important role for MMP-2 expression rather than MMP-2 activity in anti-angiogenesis." 02/01/2011 - "The current study used the ExcelArray Human MMP/TIMP Array to quantify MMP and tissue inhibitor of metalloproteinase (TIMP) production in the lysates and media of 14 cancer cell lines and 1 normal cell line. "
2.	Fibrosis (Cirrhosis) 01/01/2007 - "Studies presenting a time course for MMP and TIMP expression during recovery from hepatic fibrosis were taken into consideration to point out a synchronizing behavior in the expression pattern." 05/01/2006 - "This study reveals that the overexpression of MMP-1, which is associated with an increased ratio of MMP-1/TIMP-1 in DCM, indicates an activated collagenolytic system while replacement fibrosis is accumulating. " 06/01/2005 - "To study the effect of SiO(2) on the expression of matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) in human alveolar macrophages (AMs) associated with the pathogenesis of silicotic fibrosis. " 05/01/2015 - "This classical role for TIMPs suggests that increased TIMP levels results in ECM accumulation (or fibrosis), whereas loss of TIMPs leads to enhanced matrix proteolysis. " 01/01/2015 - "MSC can improve MMP-TIMP expression in injured myocardium and interfere with myocardial fibrosis after homing, a mechanism that may be related to the STAT-mediated signaling pathway."
3.	Liver Cirrhosis (Hepatic Cirrhosis) 05/10/2002 - "High dose recombinant human augmenter of liver regeneration is effective in inhibiting gene expression of TIMP(1) in experimental liver fibrosis." 05/21/2013 - "The ZnPP group also showed inhibited TGF-β1 expression and regulated TIMP-1/MMP-2 expression, as well as obviously attenuated liver fibrosis. " 01/01/2012 - "mansoni-induced liver fibrosis, probably by modulating the relative expression of MMP and TIMP. " 10/01/2002 - "The active MMP-2/proMMP-2 ratio decreased with the grade of liver fibrosis, and was negatively correlated with serum levels of tissue inhibitor of metalloproteinases (TIMP)-2. " 10/01/2002 - "The TIMP-Tg mice showed significantly attenuated resolution of spontaneous liver fibrosis compared with the Cont mice. "
4.	Inflammation 01/01/2005 - "The aim of the present study was to investigate whether a natural treatment is effective in reducing cartilage inflammation and degradation by influencing MMP and TIMP serum levels. " 02/01/1999 - "The low MMP-9:TIMP-1 ratio observed in subjects with little or no FEV1 improvement with CS supports the hypothesis that, in these asthmatic subjects, bronchial fibrogenesis predominates over inflammation." 11/01/2015 - "Our findings demonstrate that a significant MMP-9/TIMP-1 imbalance exists in patients with FMF, which reflects an ongoing inflammation in both FMF periods. " 08/01/2015 - "Alterations in MMP/TIMP system triggered by local and systemic inflammation may be implicated in the pathogenesis of PCOS, or the deterioration of its clinical presentation. " 01/01/2014 - "Elevated MMP-to-TIMP ratios and MMP activity suggest an imbalance in tear MMP regulation that may explain the predisposition of these patients to demonstrate corneal melting and chronic complications associated with persistent inflammation. "
5.	Heart Failure 09/01/2012 - "Tissue inhibitor of metalloproteinases (TIMPs) in heart failure." 09/01/2008 - "This article reviews the recent clinical, genetic and experimental approaches employed to compare ECM, MMP and TIMP profiles in healthy, compensated and failing hearts and identifies common themes in the perturbation of ECM homeostasis in the transition to heart failure." 04/01/2008 - "The prognostic utility of TIMP is unknown in chronic heart failure (CHF). " 04/01/2008 - "Tissue inhibitor of metalloproteinases levels in patients with chronic heart failure: an independent predictor of mortality." 05/01/2000 - "MMP/TIMP expression in spontaneously hypertensive heart failure rats: the effect of ACE- and MMP-inhibition."

Related Drugs and Biologics

1.	Metalloproteases (Metalloproteinases)
2.	Tissue Inhibitor of Metalloproteinase-2
3.	Collagen
4.	Matrix Metalloproteinases
5.	Tissue Inhibitor of Metalloproteinase-1
6.	Messenger RNA (mRNA)
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Transforming Growth Factors (Transforming Growth Factor)
9.	Proteins (Proteins, Gene)
10.	Biological Markers (Surrogate Marker)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Drug Therapy (Chemotherapy)
3.	Transplantation (Transplant Recipients)
4.	Stents
5.	Muscle Stretching Exercises (Stretching, Static)