CCR5 Receptors (CCR5 Receptor)

CCR receptors with specificity for CHEMOKINE CCL3; CHEMOKINE CCL4; and CHEMOKINE CCL5. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; MACROPHAGES; MAST CELLS; and NK CELLS. The CCR5 receptor is used by the HUMAN IMMUNODEFICIENCY VIRUS to infect cells.

Also Known As:

Networked: 392 relevant articles (9 outcomes, 38 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhang, Yan: 8 articles (09/2015 - 08/2010)
2.	Arnatt, Christopher K: 6 articles (05/2014 - 09/2011)
3.	Haney, Kendra M: 6 articles (05/2014 - 08/2010)
4.	Spengler, Ulrich: 6 articles (01/2009 - 06/2002)
5.	Kuziel, William A: 6 articles (11/2007 - 03/2003)
6.	Ahuja, Sunil K: 5 articles (08/2015 - 09/2005)
7.	Sauerbruch, Tilman: 5 articles (01/2009 - 06/2002)
8.	Ho, Wen-Zhe: 5 articles (12/2003 - 11/2002)
9.	Douglas, Steven D: 5 articles (12/2003 - 11/2002)
10.	Guo, Chang-Jiang: 5 articles (12/2003 - 11/2002)

Related Diseases

1.	Infection 01/01/2013 - "In this study, we investigated CC chemokine receptor 5 (CCR5-59029) polymorphism which is considered an important component of the immune system in determining the outcome of HCV infection. " 01/01/2012 - "In the current study we have investigated the immune responses against JEV in mice lacking expression of the chemokine receptor CCR5, which functions in activation and chemotaxis of leukocytes during infection. " 07/01/2006 - "A new study suggests a link between CCR5Delta32 (a common mutant allele of the chemokine and HIV receptor CCR5) and fatal WNV infection. " 01/01/2003 - "Several studies have investigated whether heterozygosity for a 32-basepair deletion in the CC chemokine receptor 5 gene (CCR5-Delta32 ) affects susceptibility to perinatal HIV-1 infection, but results have been inconclusive. " 04/01/2002 - "Collectively, these data provide preliminary evidence that BIV may utilize the CCR5 receptor for infection of cells in vitro, but additional studies are necessary to confirm this."
2.	Rheumatoid Arthritis 07/01/2002 - "The objective was to study the potential role of the chemokine receptor CCR5 in the chemoattraction of lymphocytes by rheumatoid arthritis synovial fluid (RA-SF). " 06/01/2002 - "To study expression and function of the chemokine receptor CCR5 in synovial fluid (SF) T cells from patients with rheumatoid arthritis (RA). " 06/01/2012 - "We found an increase in the genetic frequency of the A allele in the 59029 A→G promoter region of the CCR5 receptor in patients with rheumatoid arthritis compared with healthy controls (p = 0.01; OR = 1.5, 95% CI (1.0-2.2). " 11/01/2010 - "To investigate both the preclinical effects of blocking the chemokine receptor CCR5 and the clinical effects of this approach on the signs and symptoms of rheumatoid arthritis (RA) in patients with active disease. " 09/01/2009 - "The chemokine (C-C motif) receptor CCR5 and its ligand CCL5 play key roles in the intra-articular recruitment of peripheral blood mononuclear cells (PBMC) in rheumatoid arthritis (RA). "
3.	Plague (Bubonic Plague) 02/12/2004 - "A recent and prevalent mutation in the chemokine receptor CCR5 in humans of northern European ancestry has been proposed to provide protection against bubonic plague. " 07/22/2004 - "Mecsas and colleagues suggest that a deficiency in the chemokine receptor CCR5 in humans is unlikely to confer protection against plague, based on their study of Yersinia pestis infection in Ccr5-deficient mice. "
4.	HIV Infections (HIV Infection) 01/01/2014 - "Several studies have confirmed that genetic variants in chemokine receptor CCR5 gene are correlated with susceptibility and resistance to HIV infection. " 07/01/2006 - "The discovery of CCR5 receptor antagonists for the treatment of HIV infection: hit-to-lead studies." 05/01/2015 - "High expression of chemokine receptor CCR5 by most iNKT cells suggests that these cells might be more favorable targets of HIV infection. " 04/01/2014 - "The chemokine receptor CCR5 is essential for HIV infection and is thus a potential target for vaccine development. " 03/01/2013 - "Treatment of CD4(+) T cells with zinc-finger protein nucleases (ZFNs) specifically disrupting chemokine receptor CCR5 coding sequences induces resistance to HIV infection in vitro and in vivo. "
5.	Disease Progression 01/01/2012 - "LPS is a likely marker of disease progression, as it drives chronic monocyte activation, and some studies suggest that hyperexpression of CCR5 receptors, related to LPS plasma levels, could be responsible for monocyte trafficking in the brain compartment and for the appearance of HIV-associated neurocognitive disorders. " 04/01/2014 - "Immunohistochemistry, histology, and real-time reverse transcription polymerase chain reaction (RT-PCR) were performed to assess the disease progression and upregulation of CCR5 receptor. " 06/18/2004 - "An evolutionary-based analysis of the CC chemokine receptor 5 gene (CCR5) promoter region has identified nine stable human haplogroups, within which certain haplogroups appear to influence HIV-1 disease progression differentially among Caucasians and African-Americans. " 06/01/2001 - "If CC chemokine receptor 5 (CCR5)-dependent mechanisms at the time of initial virus exposure are important determinants of virus entry and disease outcome, then the polymorphisms in CCR5 that influence risk of transmission and disease progression should be similar; this hypothesis was tested in a cohort of 649 Argentinean children exposed perinatally to human immunodeficiency virus type 1 (HIV-1). " 06/01/2001 - "Concordance between the CC chemokine receptor 5 genetic determinants that alter risks of transmission and disease progression in children exposed perinatally to human immunodeficiency virus."

Related Drugs and Biologics

1.	Ligands
2.	CCR5 Receptors (CCR5 Receptor)
3.	maraviroc
4.	Carbon Monoxide
5.	Methotrexate (Mexate)
6.	CXCR4 Receptors (CXCR4 Receptor)
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN)
9.	Transforming Growth Factor beta1 (TGF beta 1)
10.	Interleukin-7 Receptor alpha Subunit

Related Therapies and Procedures

1.	Highly Active Antiretroviral Therapy (HAART)
2.	Immunotherapy
3.	Transplantation (Transplant Recipients)
4.	Transplants (Transplant)
5.	Lasers (Laser)